Apparatus and method for transpericardial delivery of fluid

Claim 1

An apparatus comprising: an elongated catheter body having a proximal and distal segment, said body defining first and second lumens extending therethrough, first and second conductive leads within said body, said second lumen extending into a plurality of passages connecting said second lumen to the exterior of said distal segment, an expandable balloon mounted to an outer surface of said distal segment of said body to envelop said passages, thereby defining a balloon cavity between the balloon and said outer surface, a charge plate radially opposite said balloon and connected to said first lead, an iontophoretic pad radially opposite said balloon and adjacent to and in electroconductive contact with said charge plate, an electrode adjacent the periphery of said pad electrically insulated from said pad and charge plate, said electrode being connected to said second lead, and a catheter sheath surrounding at least a portion of said catheter body.

Claim 2

An apparatus comprising: an elongated catheter body having a proximal and distal segment, said body defining first and second lumens extending therethrough, first and second conductive leads within said body, said second lumen extending into a plurality of passages connecting said second lumen to the exterior of said distal segment, an expandable balloon mounted to an outer surface of said distal segment of said body to envelop said passages, thereby defining a balloon cavity between the balloon and said outer surface, a charge plate radially opposite said balloon and connected to said first lead, an iontophoretic pad radially opposite said balloon and adjacent to and in electroconductive contact with said charge plate, an electrode adjacent the periphery of said pad electrically insulated from said pad and charge plate, said electrode being connected to said second lead, and a catheter sheath surrounding at least a portion of said catheter body.

Claim 8

A method of delivering a bioactive substance, which comprises: percutaneously inserting into a patient and positioning outside an anatomical passageway and over a selected tissue surface a distal end of a distally expandable member having pores opening to the exterior of the distal end from a chamber provided upon expansion of said distal end, said chamber being connected by a lumen in the member that opens proximally exteriorly of the member, and introducing a gaseous fluid containing a bioactive substance into said lumen under pressure, thereby expanding said distal end of said member to press it against the tissue surface and deliver said bioactive substance through said pores at said tissue surface.

Claim 9

A method of delivering a bioactive substance, which comprises: percutaneously inserting into a patient and positioning outside an anatomical passageway and over a selected tissue surface a distal end of a distally expandable member having pores opening to the exterior of the distal end from a chamber provided upon expansion of said distal end, said chamber being connected by a lumen in the member that opens proximally exteriorly of the member, and introducing a gaseous fluid containing a bioactive substance into said lumen under pressure, thereby expanding said distal end of said member to press it against the tissue surface and deliver said bioactive substance through said pores at said tissue surface.

Claim 12

A method of delivering a bioactive substance, which comprises: providing an apparatus comprising an elongated catheter member having a proximal and distal segment, said catheter member including at least first and second lumens extending thereinto and exiting said catheter member through separate radially spaced first and second passages in said distal segment, a balloon mounted to at least a portion of the exterior of said catheter member distal segment and enveloping said second passage but not said first passage, thereby affording a balloon cavity between the balloon and said distal segment exterior, said second passage opening into said cavity, and an expandable bag mounted to an exterior surface of said distal segment of said catheter member adjacent and radially opposite said balloon and over said first passage, thereby affording a bag chamber between the bag and said radially adjacent exterior surface into which said first passage opens, said bag having pores for passage of fluid therethough to the exterior thereof radially opposite said balloon, percutaneously inserting said distal segment into a patient and positioning said distal segment outside an anatomical passageway and over a selected tissue surface, introducing a fluid through said second lumen to expand said balloon to press said bag of the distal segment against the tissue surface, and introducing a fluid containing a bioactive substance into said first lumen and delivering the fluid at said tissue surface from said pores of said bag.

Claim 13

A method of delivering a bioactive substance, which comprises: providing an apparatus comprising an elongated catheter member having a proximal and distal segment, said catheter member including at least first and second lumens extending thereinto and exiting said catheter member through separate radially spaced first and second passages in said distal segment, a balloon mounted to at least a portion of the exterior of said catheter member distal segment and enveloping said second passage but not said first passage, thereby affording a balloon cavity between the balloon and said distal segment exterior, said second passage opening into said cavity, and an expandable bag mounted to an exterior surface of said distal segment of said catheter member adjacent and radially opposite said balloon and over said first passage, thereby affording a bag chamber between the bag and said radially adjacent exterior surface into which said first passage opens, said bag having pores for passage of fluid therethough to the exterior thereof radially opposite said balloon, percutaneously inserting said distal segment into a patient and positioning said distal segment outside an anatomical passageway and over a selected tissue surface, introducing a fluid through said second lumen to expand said balloon to press said bag of the distal segment against the tissue surface, and introducing a fluid containing a bioactive substance into said first lumen and delivering the fluid at said tissue surface from said pores of said bag.

Claim 17

A method of delivering a bioactive substance, which comprises: percutaneously inserting into a patient and positioning outside an anatomical passageway and over a selected tissue surface the distal end of a distally expandable member having an external iontophoretic pad containing a bioactive substance and in electroconductive contact with a radially inward charge plate connected to a first lead and with an electrode adjacent the periphery of said pad electrically insulated from said pad and charge plate and connected to a second lead, expanding said distally end of said member to press said iontophoretic pad against the tissue surface, and supplying voltage to said first lead to establish an electrical circuit with said second electrode and iontophoretically drive said bioactive substance from said pad into the tissue surface.

Claim 18

A method of delivering a bioactive substance, which comprises: percutaneously inserting into a patient and positioning outside an anatomical passageway and over a selected tissue surface the distal end of a distally expandable member having an external iontophoretic pad containing a bioactive substance and in electroconductive contact with a radially inward charge plate connected to a first lead and with an electrode adjacent the periphery of said pad electrically insulated from said pad and charge plate and connected to a second lead, expanding said distally end of said member to press said iontophoretic pad against the tissue surface, and supplying voltage to said first lead to establish an electrical circuit with said second electrode and iontophoretically drive said bioactive substance from said pad into the tissue surface.

Claim 21

A method of delivering a bioactive substance which comprises: providing an apparatus comprising an elongated catheter member having a proximal and distal segment, said catheter member including at least first and second lumens extending thereinto and exiting said catheter member through separate radially spaced first and second passages in said distal segment, a balloon mounted to at least a portion of the exterior of said catheter member distal segment and enveloping said second passage but not said first passage, thereby affording a balloon cavity between the balloon and said distal segment exterior, said second passage opening into said cavity, an expandable bag mounted to an exterior surface of said distal segment of said catheter member adjacent and radially opposite said balloon and over said first passage, thereby providing a bag chamber between the bag and said radially adjacent exterior surface into which said first passage opens, said bag comprising an iontophoretic pad on an external surface, said apparatus further comprising first and second electroconductive leads in said member, a charge plate connected to said first lead and adjacent said pad in electroconductive contact therewith, and an electrode adjacent the periphery of said pad electrically insulated from said pad and charge plate and connected to said second lead, percutaneously inserting said distal segment into a patient and positioning said distal segment outside an anatomical passageway and over a selected tissue, introducing fluid through said first and second lumens to expand said balloon and bag to press said pad on the distal segment against the tissue surface, and supplying voltage to said first lead to establish an electrical circuit with said second electrode and iontophoretically drive said bioactive substance from said pad into the tissue surface.

Claim 22

A method of delivering a bioactive substance which comprises: providing an apparatus comprising an elongated catheter member having a proximal and distal segment, said catheter member including at least first and second lumens extending thereinto and exiting said catheter member through separate radially spaced first and second passages in said distal segment, a balloon mounted to at least a portion of the exterior of said catheter member distal segment and enveloping said second passage but not said first passage, thereby affording a balloon cavity between the balloon and said distal segment exterior, said second passage opening into said cavity, an expandable bag mounted to an exterior surface of said distal segment of said catheter member adjacent and radially opposite said balloon and over said first passage, thereby providing a bag chamber between the bag and said radially adjacent exterior surface into which said first passage opens, said bag comprising an iontophoretic pad on an external surface, said apparatus further comprising first and second electroconductive leads in said member, a charge plate connected to said first lead and adjacent said pad in electroconductive contact therewith, and an electrode adjacent the periphery of said pad electrically insulated from said pad and charge plate and connected to said second lead, percutaneously inserting said distal segment into a patient and positioning said distal segment outside an anatomical passageway and over a selected tissue, introducing fluid through said first and second lumens to expand said balloon and bag to press said pad on the distal segment against the tissue surface, and supplying voltage to said first lead to establish an electrical circuit with said second electrode and iontophoretically drive said bioactive substance from said pad into the tissue surface.

Claim 28

A method of delivering a bioactive substance, which comprises: percutaneously inserting into a patient and positioning outside an anatomical passageway and over a selected tissue surface a distal end of a distally expandable member having pores opening to the exterior of the distal end from a chamber provided upon expansion of said distal end, said chamber being connected by a lumen in the member that opens proximally exteriorly of the member, introducing a fluid containing a bioactive substance into said lumen to expand said distal end, and causing said fluid to issue through said pores at the tissue surface.

Claim 29

A method of delivering a bioactive substance, which comprises: percutaneously inserting into a patient and positioning outside an anatomical passageway and over a selected tissue surface a distal end of a distally expandable member having pores opening to the exterior of the distal end from a chamber provided upon expansion of said distal end, said chamber being connected by a lumen in the member that opens proximally exteriorly of the member, introducing a fluid containing a bioactive substance into said lumen to expand said distal end, and causing said fluid to issue through said pores at the tissue surface.