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US6458092B1 Expired / Lapsed US ⏱️ 0.0 years remaining

Vascular inducing implants

Assignee: CR Bard Inc
•
Filing: 1998-09-30
•
Granted: 2002-10-01
•
Expires: 2018-09-30
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Abstract

Abstract Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to have a first configuration having a low profile and an expanded, second configuration having a large profile. The implants are delivered to the ischemic tissue location in the first configuration, implanted then expanded to the second configuration. The expanded implants maintain a stress on the surrounding tissue, irritating and slightly injuring the tissue to provoke an injury response that results in angiogenesis. The flow of blood from the surrounding tissue into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth. This healing process leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

Inventors

  • 👤 Richard A. Gambale
  • 👤 Stephen J. Forcucci
  • 👤 Michael F. Weiser
  • 👤 Richard T. Choh
  • 👤 Sean Forde

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 08:09
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/94; A61B; A61B17/00; A61B17/00234; A61F2/02; A61F2/04; A61F2/06; A61F2/24; A61F2/2493; A61B2017/00238; A61B2017/00243; A61F2220/00; A61F2220/0008; A61F2220/0016; A61F2220/0025; A61F2220/005; A61F2220/0058; A61F2230/00; A61F2230/0063; A61F2230/0073; A61F2230/0076; A61F2230/0091; A61F2250/00; A61F2250/0058; A61F2250/0067

Claims Analysis

Total Claims: 11
Claim 1
Independent Claim 69 words
An implant device for implantation into tissue comprising: an implant having a first configuration with a first profile and a second configuration having a second profile that is greater than the first profile whereby surrounding tissue into which the implant is placed is stressed and irritated sufficiently to cause an injury response including thrombus formation that initiates angiogenesis; and an angiogenic substance for promoting angiogenesis associated with the implant.
Claim 2
Dependent Claim 69 words
An implant device for implantation into tissue comprising: an implant having a first configuration with a first profile and a second configuration having a second profile that is greater than the first profile whereby surrounding tissue into which the implant is placed is stressed and irritated sufficiently to cause an injury response including thrombus formation that initiates angiogenesis; and an angiogenic substance for promoting angiogenesis associated with the implant.
Claim 3
Dependent Claim 20 words
An implant device as defined in claim 1 wherein the angiogenic substance is joined to the device by a coating.
Claim 4
Dependent Claim 24 words
A device as defined in claim 1 wherein the angiogenic substance becomes associated with the device after the device is delivered into the tissue.
Claim 5
Dependent Claim 33 words
An implant device as defined in claim 3 wherein the body of the device defines a hollow interior and the angiogenic substance is inserted into the hollow interior after the device is implanted.
Claim 6
Dependent Claim 34 words
An implant device as defined in claim 1 , wherein the body of the device defines a hollow interior and an angiogenic substance loaded into the hollow interior prior to implantation of the device.
Claim 7
Dependent Claim 36 words
An implant device as defined in claim 5 further comprising at least one opening in the body of a size to permit the angiogenic substance to transfer from the interior to the outside of the device.
Claim 8
Dependent Claim 21 words
An implant device as defined in claim 1 wherein the angiogenic substance becomes associated with the implant after it is implanted.
Claim 9
Dependent Claim 14 words
An implant device as defined in claim 1 wherein the implant is a cylinder.
Claim 10
Dependent Claim 23 words
An implant as defined in claim 1 further comprising a spring that is resiliently expandable from the first configuration to the second configuration.
Claim 11
Dependent Claim 18 words
An implant device as defined in claim 1 wherein the implant is flexible after assuming the second configuration.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2005-09-30 2006-04-01 2006-10-01 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2009-09-30 2010-04-01 2010-10-01 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2013-09-30 2014-04-01 2014-10-01 $7700.00 Window Closed / Lapsed

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