US5861032A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical device having a biocompatible coating and oxidation method of coupling therefor
Assignee: Surface Genesis Inc
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Filing: 1996-01-31
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Granted: 1999-01-19
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Expires: 2016-01-31
Abstract
Abstract A medical device for implantation in the tissue of a human body having a biocompatible coating thereon including a foreign body formed of a material which is substantially biocompatible with the tissue of the human body. The foreign body has a surface adapted to come in contact with the tissue of the human body and is capable of being oxidized. An organic linker is carried on the surface and forms an oxidative coupling with the surface. A bioactive agent is bonded to the organic linker by a chemical reaction or photochemical function.
Inventors
- 👤 Raj Subramaniam
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 22:28
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/02; A61L27/04; A61L27/042; A61L27/06; A61L27/34; A61L27/50; A61L27/54; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61F; A61F2/00; A61F2/02; A61F2/12; A61F2/82
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
95 words
A medical device for implantation in the tissue of a human body having a biocompatible coating thereon, said device comprising a foreign body formed of a material which is substantially biocompatible with the tissue of the human body, said foreign body having a surface adapted to come in contact with the tissue of the human body, said surface being capable of being oxidized, said coating including an organic linker bonded directly to said surface and forming an oxidative coupling with said surface, and a bioactive agent bonded to the organic linker by a reactive function.
Claim 2
Dependent Claim
95 words
A medical device for implantation in the tissue of a human body having a biocompatible coating thereon, said device comprising a foreign body formed of a material which is substantially biocompatible with the tissue of the human body, said foreign body having a surface adapted to come in contact with the tissue of the human body, said surface being capable of being oxidized, said coating including an organic linker bonded directly to said surface and forming an oxidative coupling with said surface, and a bioactive agent bonded to the organic linker by a reactive function.
Claim 3
Dependent Claim
26 words
A device as in claim 1 wherein said organic linker is selected from the group consisting of cystines, organic peroxides, organic sulfone, sulfoxide and sulfonic acids.
Claim 4
Dependent Claim
26 words
A device as in claim 2 wherein said bioactive agent is selected from the group consisting of growth promoters, anti-thrombogenic agents, steroids, antibiotics, hormones and cytokines.
Claim 5
Dependent Claim
13 words
A device as in claim 3 wherein said bioactive agent includes a peptide.
Claim 6
Dependent Claim
21 words
A device as in claim 4 wherein said peptide is in a form of 15 amino acid long cell binding peptide.
Claim 7
Dependent Claim
32 words
A device as in claim 1 wherein said reactive function is capable of undergoing a reaction selected from the group consisting of a condensation reaction, oxidative reaction, exchange reaction and substitution reaction.
Claim 8
Dependent Claim
22 words
A device as in claim 1 wherein said device is formed of a metal which is substantially biocompatible with the human body.
Claim 9
Dependent Claim
23 words
A device as in claim 7 wherein said metal is selected from the group consisting of stainless steel, titanium, and alloys of titanium.
Claim 10
Dependent Claim
13 words
A device as in claim 1 wherein said device is a dental post.
Claim 11
Dependent Claim
12 words
A device as in claim 1 wherein said device is a stent.
Claim 12
Dependent Claim
13 words
A device as in claim 1 wherein said material is formed of plastic.
Claim 13
Dependent Claim
13 words
A device as in claim 1 wherein said device is a breast implant.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-01-18 | 2002-07-20 | 2003-01-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-01-18 | 2006-07-20 | 2007-01-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-01-18 | 2010-07-20 | 2011-01-19 | $7700.00 | Window Closed / Lapsed |