Patent EP0581233A1 successfully refreshed from Google Patents.
US5354736A
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Synthetic compounds and compositions with enhanced cell binding
Assignee: CALIFORNIA A Corp OF, University of, Regents of
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Filing: 1991-12-09
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Granted: 1994-10-11
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Expires: 2011-12-09
Abstract
Abstract Compositions of the invention include composites comprising a biomaterial carrying compounds with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docketing of collagen binding species (such as cell surface receptors for collagen and fibronectin). Hydrogel matrices as the biomaterial promote cell attachment to the matrix and cell migration into the matrix.
Inventors
- 👤 Rajendra S. Bhatnagar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:30
CPC Classifications
C; C12; C12N; C12N5/00; C12N5/0068; A; A61; A61P; A61P43/00; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61K; A61K38/00; C12N2533/00; C12N2533/30; C12N2533/50; C12N2533/54
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
44 words
A periodontal repair composition comprising: hydroxylapatite particles admixed with a quantity of synthetic peptide, the peptide having a domain that mimics collagen binding to cells and has enhanced cell binding with respect to collagen, the peptide in an amount effective to promote cell attachment.
Claim 2
Dependent Claim
44 words
A periodontal repair composition comprising: hydroxylapatite particles admixed with a quantity of synthetic peptide, the peptide having a domain that mimics collagen binding to cells and has enhanced cell binding with respect to collagen, the peptide in an amount effective to promote cell attachment.
Claim 3
Dependent Claim
16 words
The periodontal repair composition as in claim 1 wherein the peptide is coated on the particles.
Claim 4
Dependent Claim
43 words
The periodontal repair composition as in claim 1 wherein the peptide has the sequence Gly-Thr-Pro-Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln-Arg-Gly-Val-Val (SEQ ID NO:l), Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln-Arg (SEQ ID NO:2), Gln-Gly-Ile-Ala-Gly-Gln (SEQ ID NO:3), Gln-Gly-Ile-Ala-Gly-Gln-Arg (SEQ ID NO:4), Phe-Gly-Ile-Ala-Gly-Phe (SEQ ID NO:5), Gly-Ile-Ala-Gly-Gln (SEQ ID NO:6), and Gln-Gly-Ala-Ile-Ala-Gln (SEQ ID NO:7).
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-10-10 | 1998-04-11 | 1998-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-10-10 | 2002-04-11 | 2002-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-10-10 | 2006-04-11 | 2006-10-11 | $7700.00 | Window Closed / Lapsed |