US5538504A
Expired / Lapsed
US
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Intra-extravascular drug delivery catheter and method
Assignee: Boston Scientific Scimed Inc
•
Filing: 1994-07-01
•
Granted: 1996-07-23
•
Expires: 2014-07-01
Abstract
Abstract A drug delivery catheter is provided which includes a catheter comprised of an elongated tubular shaft with an inner lumen and a vessel puncturing element which is housed in the lumen. The puncturing element has a retracted position such that it will not be in contact with the vessel wall as the catheter is guided through the vasculature. The puncturing element also has a puncturing position where it protrudes radially outward of the catheter shaft and engages and punctures the vessel wall. The catheter is first inserted into the vessel to be treated and the puncturing element is positioned at the site in the vessel to be treated. The puncturing element is then moved to its puncturing position and the inner surface of the vessel wall is punctured. A drug is then delivered through the puncture. The drug may be delivered into either the vessel wall itself or to the outside of the vessel wall.
Inventors
- 👤 Bradley C. Linden
- 👤 II Donald F. Palme
- 👤 Peter T. Keith
- 👤 Robert E. Atkinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:49
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/10; A61B; A61B17/00; A61B17/34; A61B17/3478; A61M25/0021; A61M25/0023; A61M25/0026; A61M2025/0037; A61M2025/004; A61M25/0043; A61M2025/0057; A61M25/0067; A61M25/0082; A61M2025/0096; A61M25/0029; A61M25/0084; A61M25/0097
Claims Analysis
Total Claims: 60
Claim 1
Independent Claim
110 words
A method of treating a vessel having a vessel wall with an inner surface, the method comprising the steps of: inserting a catheter having a vessel puncturing element disposed therein into a substantially tubular vessel; positioning the puncturing element at the site in the vessel to be treated; restraining said puncturing element such that it is maintained in a retracted position; placing said puncturing element in a puncturing position in which said puncturing element is no longer restrained; said puncturing element automatically moving in a direction substantially non-parallel with respect to a portion of said catheter that contains said puncturing element when said puncturing element is no longer being restrained.
Claim 2
Independent Claim
110 words
A method of treating a vessel having a vessel wall with an inner surface, the method comprising the steps of: inserting a catheter having a vessel puncturing element disposed therein into a substantially tubular vessel; positioning the puncturing element at the site in the vessel to be treated; restraining said puncturing element such that it is maintained in a retracted position; placing said puncturing element in a puncturing position in which said puncturing element is no longer restrained; said puncturing element automatically moving in a direction substantially non-parallel with respect to a portion of said catheter that contains said puncturing element when said puncturing element is no longer being restrained.
Claim 3
Dependent Claim
24 words
The method of claim 1 further comprising the step of puncturing the vessel wall with the puncturing element at the site to be treated.
Claim 4
Dependent Claim
33 words
The method of claim 2 further comprising the step of delivering via a delivery means a drug outside of the inner surface of the vessel wall through the puncture in the vessel wall.
Claim 5
Dependent Claim
20 words
The method of claim 3 wherein the step of delivering the drug comprises delivering the drug into the vessel wall.
Claim 6
Dependent Claim
24 words
The method of claim 3 wherein the step of delivering the drug comprises delivering the drug to the outer surface of the vessel wall.
Claim 7
Dependent Claim
23 words
The method of claim 3 wherein the step of delivering the drug comprises delivery of the drug into tissue surrounding the vessel wall.
Claim 8
Dependent Claim
24 words
The method of claim 3 wherein the step of delivering the drug comprises the step of delivering a drug in a time release module.
Claim 9
Dependent Claim
35 words
The method of claim 3 wherein the delivery means includes said puncturing element having a drug delivery lumen and wherein the step of delivering the drug comprises delivering the drug through the drug delivery lumen.
Claim 10
Dependent Claim
17 words
The method of claim 1 wherein said drug comprises an antiproliferative drug for the treatment of restenosis.
Claim 11
Dependent Claim
18 words
The method of claim 1 wherein said drug comprises an antiproliferative drug for the treatment of vascular disease.
Claim 12
Dependent Claim
15 words
The method of claim 1 wherein said drug comprises a specific inhibitor of cellular proliferation.
Claim 13
Dependent Claim
14 words
The method of claim 1 wherein said drug comprises a specific inhibitor of thrombin.
Claim 14
Dependent Claim
14 words
The method of claim 1 wherein said drug comprises a specific inhibitor of platelets.
Claim 15
Dependent Claim
12 words
The method of claim 1 wherein said drug comprises a genetic material.
Claim 16
Dependent Claim
24 words
The method of claim 1 wherein said drug comprises a genetic material that when incorporated into cells results in the expression of therapeutic materials.
Claim 17
Dependent Claim
15 words
The method of claim 1 wherein said drug is incorporated into a time released matrix.
Claim 18
Independent Claim
104 words
A method of treating a vessel having a vessel wall with an inner surface, the method comprising the steps of: inserting a catheter having a vessel puncturing element disposed therein into a substantially tubular vessel; positioning the puncturing element at the site in the vessel to be treated; inflating an inflatable compartment adjacent said puncturing element to thereby apply an adjacent force adjacent said puncturing element to move said puncturing element in a direction substantially non-parallel with respect to a portion of said catheter that contains said puncturing element, said adjacent force moving said puncturing element from a retracted position to a puncturing position.
Claim 19
Independent Claim
104 words
A method of treating a vessel having a vessel wall with an inner surface, the method comprising the steps of: inserting a catheter having a vessel puncturing element disposed therein into a substantially tubular vessel; positioning the puncturing element at the site in the vessel to be treated; inflating an inflatable compartment adjacent said puncturing element to thereby apply an adjacent force adjacent said puncturing element to move said puncturing element in a direction substantially non-parallel with respect to a portion of said catheter that contains said puncturing element, said adjacent force moving said puncturing element from a retracted position to a puncturing position.
Claim 20
Dependent Claim
18 words
The method of claim 17 further comprising the step of puncturing the vessel wall with the puncturing element.
Claim 21
Dependent Claim
33 words
The method of claim 18 further comprising the step of delivering via a delivery means a drug outside of the inner surface of the vessel wall through the puncture in the vessel wall.
Claim 22
Dependent Claim
20 words
The method of claim 19 wherein the step of delivering the drug comprises delivering the drug into the vessel wall.
Claim 23
Dependent Claim
33 words
The method of claim 19 wherein the step of applying said force moves said puncturing element a predetermined distance such that said drug is delivered to an outer surface of the vessel wall.
Claim 24
Dependent Claim
23 words
The method of claim 19 wherein the step of delivering the drug comprises delivery of the drug into tissue surrounding the vessel wall.
Claim 25
Dependent Claim
24 words
The method of claim 19 wherein the step of delivering the drug comprises the step of delivering a drug in a time release module.
Claim 26
Dependent Claim
35 words
The method of claim 19 wherein the delivery means includes said puncturing element having a drug delivery lumen and wherein the step of delivering the drug comprises delivering the drug through the drug delivery lumen.
Claim 27
Dependent Claim
20 words
The method of claim 17 wherein said compartment inflates a predetermined amount to move said puncturing element a predetermined distance.
Claim 28
Dependent Claim
169 words
A drug delivery device for treating a vessel having a vessel wall with an inner surface, the device comprising: an elongated catheter adapted to be inserted into the vessel; said catheter comprising a puncturing element having a retracted position in which said puncturing element does not puncture said vessel wall, at least a portion of said puncturing element being housed in a portion of said catheter when said puncturing element is in said retracted position; a restraint that contacts and holds said puncturing element in said retracted position; said puncturing element further having a puncturing position in which said puncturing element engages and punctures said vessel wall, said puncturing element being substantially non-parallel with respect to said portion of said catheter when said puncturing element is in said puncturing position; said puncturing element automatically moving from said retracted position to said puncturing position when said restraint is no longer being applied; and delivery means coupled to said catheter and delivering a drug through a puncture in the vessel wall.
Claim 29
Dependent Claim
169 words
A drug delivery device for treating a vessel having a vessel wall with an inner surface, the device comprising: an elongated catheter adapted to be inserted into the vessel; said catheter comprising a puncturing element having a retracted position in which said puncturing element does not puncture said vessel wall, at least a portion of said puncturing element being housed in a portion of said catheter when said puncturing element is in said retracted position; a restraint that contacts and holds said puncturing element in said retracted position; said puncturing element further having a puncturing position in which said puncturing element engages and punctures said vessel wall, said puncturing element being substantially non-parallel with respect to said portion of said catheter when said puncturing element is in said puncturing position; said puncturing element automatically moving from said retracted position to said puncturing position when said restraint is no longer being applied; and delivery means coupled to said catheter and delivering a drug through a puncture in the vessel wall.
Claim 30
Dependent Claim
51 words
The device defined in claim 26 wherein: said puncturing element further comprises a puncturing tip for puncturing said vessel wall when said puncturing element is in said puncturing position; and said catheter further comprises a window through which said puncturing tip extends when said puncturing element is in said puncturing position.
Claim 31
Dependent Claim
33 words
The device defined in claim 26 wherein said catheter further comprises: an inflatable balloon coupled to said catheter; and an inflation lumen extending through said catheter for delivering inflation fluid to said balloon.
Claim 32
Dependent Claim
67 words
The device defined in claim 26 wherein: said puncturing element further comprises an elongated shaft having a proximal and a distal end and an inner shaft lumen, and a needle, attached to said distal end of said shaft, having an inner needle lumen which is in fluid communication with said inner shaft lumen; and said delivery means comprises said inner shaft lumen and said inner needle lumen.
Claim 33
Dependent Claim
30 words
The device defined in claim 29 wherein said needle further comprises a puncturing tip for engaging and puncturing said vessel wall when said puncturing element is in said puncturing position.
Claim 34
Dependent Claim
35 words
The device defined in claim 30 wherein said puncturing tip includes an opening in communication with said inner needle lumen so that fluid in said inner needle lumen can flow out of said tip opening.
Claim 35
Dependent Claim
29 words
The device defined in claim 31 wherein said delivery means further comprises an injection device coupled to said inner shaft lumen for injecting fluid through said inner shaft lumen.
Claim 36
Dependent Claim
19 words
The device defined in claim 30 wherein said puncturing tip has a beveled edge for puncturing said vessel wall.
Claim 37
Dependent Claim
21 words
The device defined in claim 26 wherein said puncturing element comprises a needle having a tip for puncturing said vessel wall.
Claim 38
Dependent Claim
43 words
The device defined in claim 34 wherein: said needle is bent into a substantially U-shape when said puncturing element is in said retracted position; and said needle is extended out to form a predetermined angle when said needle is in said puncturing position.
Claim 39
Dependent Claim
45 words
The device defined in claim 34 wherein: said needle is bent to a first predetermined angle when said puncturing element is in said retracted position; and said needle is extended out to form a second predetermined angle when said needle is in said puncturing position.
Claim 40
Dependent Claim
46 words
The device defined in claim 34 wherein said needle is substantially parallel with said portion of said catheter when said needle is in said retracted position, said needle also being substantially non-parallel with said portion of said catheter when said needle is in said puncturing position.
Claim 41
Dependent Claim
158 words
A drug delivery device for treating a vessel having a vessel wall with an inner surface, the device comprising: an elongated catheter adapted to be inserted into the vessel; said catheter comprising a puncturing element having a retracted position in which said puncturing element does not puncture said vessel wall, at least a portion of said puncturing element being housed in a portion of said catheter when said puncturing element is in said retracted position; said puncturing element further having a puncturing position in which said puncturing element engages and punctures said vessel wall, said puncturing element being substantially non-parallel with respect to said portion of said catheter when said puncturing element is in said puncturing position; a movable surface comprising an inflatable compartment coupled to said catheter and adjacent said puncturing element to contact and move said puncturing element from said retracted position to said puncturing position when said movable surface is moved toward said puncturing element.
Claim 42
Dependent Claim
158 words
A drug delivery device for treating a vessel having a vessel wall with an inner surface, the device comprising: an elongated catheter adapted to be inserted into the vessel; said catheter comprising a puncturing element having a retracted position in which said puncturing element does not puncture said vessel wall, at least a portion of said puncturing element being housed in a portion of said catheter when said puncturing element is in said retracted position; said puncturing element further having a puncturing position in which said puncturing element engages and punctures said vessel wall, said puncturing element being substantially non-parallel with respect to said portion of said catheter when said puncturing element is in said puncturing position; a movable surface comprising an inflatable compartment coupled to said catheter and adjacent said puncturing element to contact and move said puncturing element from said retracted position to said puncturing position when said movable surface is moved toward said puncturing element.
Claim 43
Dependent Claim
20 words
The device of claim 38 wherein said movable surface is moved toward said puncturing element by inflating said inflatable compartment.
Claim 44
Dependent Claim
32 words
The device of claim 38 further comprising delivery means coupled to said catheter for delivering a drug outside the inner surface of the vessel wall through a puncture in the vessel wall.
Claim 45
Dependent Claim
51 words
The device defined in claim 40 wherein: said puncturing element further comprises a puncturing tip for puncturing said vessel wall when said puncturing element is in said puncturing position; and said catheter further comprises a window through which said puncturing tip extends when said puncturing element is in said puncturing position.
Claim 46
Dependent Claim
29 words
The device defined in claim 40 wherein: said inflatable compartment comprises an inflatable balloon; and an inflation lumen extends through said catheter for delivering inflation fluid to said balloon.
Claim 47
Dependent Claim
67 words
The device defined in claim 40 wherein: said puncturing element further comprises an elongated shaft having a proximal and a distal end and an inner shaft lumen, and a needle, attached to said distal end of said shaft, having an inner needle lumen which is in fluid communication with said inner shaft lumen; and said delivery means comprises said inner shaft lumen and said inner needle lumen.
Claim 48
Dependent Claim
30 words
The device defined in claim 43 wherein said needle further comprises a puncturing tip for engaging and puncturing said vessel wall when said puncturing element is in said puncturing position.
Claim 49
Dependent Claim
35 words
The device defined in claim 44 wherein said puncturing tip includes an opening in communication with said inner needle lumen so that fluid in said inner needle lumen can flow out of said tip opening.
Claim 50
Dependent Claim
29 words
The device defined in claim 45 wherein said delivery means further comprises an injection device coupled to said inner shaft lumen for injecting fluid through said inner shaft lumen.
Claim 51
Dependent Claim
19 words
The device defined in claim 46 wherein said puncturing tip has a beveled edge for puncturing said vessel wall.
Claim 52
Dependent Claim
17 words
The device of claim 40 wherein said drug comprises an antiproliferative drug for the treatment of restenosis.
Claim 53
Dependent Claim
18 words
The device of claim 40 wherein said drug comprises an antiproliferative drug for the treatment of vascular disease.
Claim 54
Dependent Claim
15 words
The device of claim 40 wherein said drug comprises a specific inhibitor of cellular proliferation.
Claim 55
Dependent Claim
14 words
The device of claim 40 wherein said drug comprises a specific inhibitor of thrombin.
Claim 56
Dependent Claim
14 words
The device of claim 40 wherein said drug comprises a specific inhibitor of platelets.
Claim 57
Dependent Claim
12 words
The device of claim 40 wherein said drug comprises a genetic material.
Claim 58
Dependent Claim
24 words
The device of claim 40 wherein said drug comprises a genetic material that when incorporated into cells results in the expression of therapeutic materials.
Claim 59
Dependent Claim
15 words
The device of claim 40 wherein said drug is incorporated into a time released matrix.
Claim 60
Dependent Claim
21 words
The device defined in claim 38 wherein said puncturing element comprises a needle having a tip for puncturing said vessel wall.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-23 | 2000-01-22 | 2000-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-23 | 2004-01-22 | 2004-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-23 | 2008-01-22 | 2008-07-23 | $7700.00 | Window Closed / Lapsed |