US6579538B1
Expired / Lapsed
US
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Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
Assignee: Acell Inc
•
Filing: 2000-10-18
•
Granted: 2003-06-17
•
Expires: 2020-10-18
Abstract
Abstract A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
Inventors
- 👤 Alan R. Spievack
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 10:49
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3633; A61L27/3641
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
43 words
A matrix, comprising: a devitalized mammalian epithelial basement membrane and tunica propria immediately subjacent to said basement membrane derived from the urinary bladder mucosa wherein said matrix induces restoration of cardiac tissue when placed in contact with diseased, damaged, or defective cardiac tissue.
Claim 2
Dependent Claim
43 words
A matrix, comprising: a devitalized mammalian epithelial basement membrane and tunica propria immediately subjacent to said basement membrane derived from the urinary bladder mucosa wherein said matrix induces restoration of cardiac tissue when placed in contact with diseased, damaged, or defective cardiac tissue.
Claim 3
Dependent Claim
20 words
The matrix of claim 1 wherein said matrix is custom-shaped to conform to said diseased, damaged, or defective cardiac tissue.
Claim 4
Dependent Claim
14 words
The matrix of claim 1 wherein said matrix comprises an injectable form of matrix.
Claim 5
Dependent Claim
13 words
The matrix of claim 1 wherein said matrix further comprises a pharmaceutical agent.
Claim 6
Dependent Claim
18 words
The matrix of claim 1 wherein said cardiac tissue is at least a portion of a cardiac valve.
Claim 7
Dependent Claim
19 words
The matrix of claim 1 wherein said matrix restores or replaces at least a portion of the interatrial septum.
Claim 8
Dependent Claim
19 words
The devitalized matrix of claim 1 wherein said cardiac tissue is at least a portion of the interventricular septum.
Claim 9
Dependent Claim
18 words
The devitalized matrix of claim 1 wherein said cardiac tissue is at least a portion of the myocardium.
Claim 10
Independent Claim
50 words
A method for inducing restoration of cardiac tissue in a mammal, said method, comprising: contacting a matrix comprising at least a portion of mammalian epithelial basement membrane and tunica propria subjacent to said basement membrane with diseased, defective, or damaged cardiac tissue, wherein said matrix induces restoration of cardiac tissue.
Claim 11
Independent Claim
50 words
A method for inducing restoration of cardiac tissue in a mammal, said method, comprising: contacting a matrix comprising at least a portion of mammalian epithelial basement membrane and tunica propria subjacent to said basement membrane with diseased, defective, or damaged cardiac tissue, wherein said matrix induces restoration of cardiac tissue.
Claim 12
Dependent Claim
20 words
The method of claim 9 wherein said restoration of diseased or defective cardiac tissue further comprises inducing endogenous epithelial repair.
Claim 13
Dependent Claim
35 words
A composition, comprising: at least a portion of devitalized epithelial basement membrane and tunica propria of a mucosa delaminated from a mammalian epithelial tissue and shaped to conform to diseased, damaged, or defective cardiac tissue.
Claim 14
Dependent Claim
35 words
A composition, comprising: at least a portion of devitalized epithelial basement membrane and tunica propria of a mucosa delaminated from a mammalian epithelial tissue and shaped to conform to diseased, damaged, or defective cardiac tissue.
Claim 15
Dependent Claim
8 words
The composition of claim 11 further comprising submucosa.
Claim 16
Dependent Claim
10 words
The composition of claim 12 further comprising the tunica muscularis.
Claim 17
Dependent Claim
13 words
The composition of claim 11 wherein said mammalian epithelial tissue comprises urinary bladder.
Claim 18
Dependent Claim
12 words
The composition of claim 11 wherein said mammalian epithelial tissue comprises intestine.
Claim 19
Dependent Claim
22 words
The composition of claim 11 wherein sad diseased, damaged, or defective cardiac tissue comprises at least a portion of a cardiac valve.
Claim 20
Dependent Claim
27 words
The composition of claim 18 wherein said cardiac valve is selected from a group consisting of pulmonic valve, aortic valve, right atrioventricular valve or left atrioventricular valve.
Claim 21
Dependent Claim
15 words
The composition of claim 11 wherein said diseased, damaged, or defective cardiac tissue comprises myocardium.
Claim 22
Dependent Claim
45 words
A matrix, comprising: a devitalized mammalian epithelial basement membrane and tunica propria immediately subjacent to said basement membrane derived from the mucosa of the intestine wherein said matrix induces restoration of healthy cardiac tissue when placed in contact with diseased, defective, or damaged cardiac tissue.
Claim 23
Dependent Claim
45 words
A matrix, comprising: a devitalized mammalian epithelial basement membrane and tunica propria immediately subjacent to said basement membrane derived from the mucosa of the intestine wherein said matrix induces restoration of healthy cardiac tissue when placed in contact with diseased, defective, or damaged cardiac tissue.
Claim 24
Dependent Claim
20 words
The matrix of claim 19 wherein said matrix is custom-shaped to conform to said diseased, defective, or damaged cardiac tissue.
Claim 25
Dependent Claim
14 words
The matrix of claim 19 wherein said matrix comprises an injectable form of matrix.
Claim 26
Dependent Claim
13 words
The matrix of claim 19 wherein said matrix further comprises a pharmaceutical agent.
Claim 27
Dependent Claim
18 words
The matrix of claim 19 wherein said cardiac tissue is at least a portion of a cardiac valve.
Claim 28
Dependent Claim
19 words
The matrix of claim 19 wherein said matrix restores or replaces at least a portion of the interatrial septum.
Claim 29
Dependent Claim
18 words
The matrix of claim 19 wherein said cardiac tissue is at least a portion of the interventricular septum.
Claim 30
Dependent Claim
17 words
The matrix of claim 19 wherein said cardiac tissue is at least a portion of the myocardium.
Claim 31
Dependent Claim
17 words
The matrix of claim 1 wherein said cardiac tissue is custom-shaped to conform to missing cardiac tissue.
Claim 32
Dependent Claim
16 words
The matrix of claim 19 wherein said matrix is custom-shaped to conform to missing cardiac tissue.
References Cited (Backward Citations)
US2127903A
Cited
US3562820A
Cited
US4801299A
Cited
US4902508A
Cited
US4956178A
Cited
US5336616A
Cited
US5445833A
Cited
US5573784A
Cited
US5281422A
Cited
US5372821A
Cited
US5352463A
Cited
US5516533A
Cited
US5275826A
Cited
US5641518A
Cited
US5891617A
Cited
US5480424A
Cited
US5899936A
Cited
US5543894A
Cited
US5695998A
Cited
US5554389A
Cited
US5762966A
Cited
US5885619A
Cited
US5711969A
Cited
US5916266A
Cited
US5755791A
Cited
WO1998022158A2
Cited
US6096347A
Cited
WO1998025637A1
Cited
WO1998025546A1
Cited
WO1998025545A1
Cited
US6126686A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-06-16 | 2006-12-16 | 2007-06-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-06-16 | 2010-12-16 | 2011-06-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-06-16 | 2014-12-16 | 2015-06-17 | $7700.00 | Window Closed / Lapsed |