US5762966A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue graft and method for urinary tract urothelium reconstruction and replacement
Assignee: Methodist Hospital
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Filing: 1997-01-15
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Granted: 1998-06-09
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Expires: 2017-01-15
Abstract
Abstract A method for surgical repair of a diseased or damaged bladder is described. Diseased or damaged bladder tissue is surgically replaced with submucosal tissue of a warm blooded vertebrate to promote regrowth of endogenous urinary bladder tissue.
Inventors
- 👤 Peter M. Knapp, Jr.
- 👤 James E. Lingeman
- 👤 Robert J. Demeter
- 👤 Stephen F. Badylak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 13:33
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3629; A61K; A61K35/00; A61K35/12; A61K35/37; A61K35/38; A61L27/3641; A61L27/3679; A61L2430/00; A61L2430/22
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
55 words
A tissue graft construct for replacement of damaged or diseased portions of a urinary bladder, said construct comprising a sheet of submucosal tissue of a warm-blooded vertebrate formed as a pouch having ports for surgical attachment and fluid communication with the ureters and the urethra for replacement of 20% or more of the urinary bladder.
Claim 2
Dependent Claim
55 words
A tissue graft construct for replacement of damaged or diseased portions of a urinary bladder, said construct comprising a sheet of submucosal tissue of a warm-blooded vertebrate formed as a pouch having ports for surgical attachment and fluid communication with the ureters and the urethra for replacement of 20% or more of the urinary bladder.
Claim 3
Dependent Claim
47 words
The tissue graft construct of claim 1 wherein said tissue graft construct is formed from two or more strips of submucosal tissue of a warm-blooded vertebrate, said graft construct having a surface area greater than any one of the individual strips used to form said graft construct.
Claim 4
Dependent Claim
34 words
The tissue graft construct of claim 1, wherein the submucosal tissue is intestinal submucosa comprising the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa.
Claim 5
Dependent Claim
38 words
A tissue graft construct for replacement of damaged or diseased portions of a urinary bladder, said construct comprising submucosal tissue of a warm-blooded vertebrate formed as a pouch for replacement of 70% or more of the urinary bladder.
Claim 6
Dependent Claim
38 words
A tissue graft construct for replacement of damaged or diseased portions of a urinary bladder, said construct comprising submucosal tissue of a warm-blooded vertebrate formed as a pouch for replacement of 70% or more of the urinary bladder.
Claim 7
Dependent Claim
24 words
The tissue graft construct of claim 4 wherein said pouch has ports for surgical attachment and fluid communication with the ureters and the urethra.
Claim 8
Dependent Claim
47 words
The tissue graft construct of claim 4 wherein said tissue graft construct is formed from two or more strips of submucosal tissue of a warm-blooded vertebrate, said graft construct having a surface area greater than any one of the individual strips used to form said graft construct.
Claim 9
Dependent Claim
34 words
The tissue graft construct of claim 4, wherein the submucosal tissue is intestinal submucosa comprising the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa.
Claim 10
Dependent Claim
49 words
A tissue graft construct for the replacement of a urinary bladder, said construct comprising submucosal tissue of a warm-blooded vertebrate in the shape of a pouch for replacement of the entire urinary bladder, said pouch having ports for surgical attachment and fluid communication with the ureters and the urethra.
Claim 11
Dependent Claim
49 words
A tissue graft construct for the replacement of a urinary bladder, said construct comprising submucosal tissue of a warm-blooded vertebrate in the shape of a pouch for replacement of the entire urinary bladder, said pouch having ports for surgical attachment and fluid communication with the ureters and the urethra.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-08 | 2001-12-08 | 2002-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-08 | 2005-12-08 | 2006-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-08 | 2009-12-08 | 2010-06-09 | $7700.00 | Window Closed / Lapsed |