Patent US2100156A successfully refreshed from Google Patents.
US6096347A
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US
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Myocardial graft constructs
Assignee: Elutia Med LLC
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Filing: 1997-11-04
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Granted: 2000-08-01
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Expires: 2017-11-04
Abstract
Abstract PCT No. PCT/US97/20240 Sec. 371 Date May 4, 1999 Sec. 102(e) Date May 4, 1999 PCT Filed Nov. 4, 1997 PCT Pub. No. WO98/19719 PCT Pub. Date May 14, 1998The use of submucosal tissue of a warm blooded vertebrate to manufacture a tissue graft composition that induces the formation of endogenous cardiac tissues in vivo upon contact of the cardiac tissues with the manufactured composition.
Inventors
- 👤 Leslie A. Geddes
- 👤 Stephen F. Badylak
- 👤 Robert G. Matheny
- 👤 William E. Schoenlein
- 👤 Fred J. Obermiller
- 👤 William J. Havel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:27
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3695; A61K; A61K35/00; A61K35/12; A61K35/37; A61K35/38; A61L27/3604; A61L27/3629; A61L27/3641; A61L27/367; A61P; A61P9/00
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
34 words
A method for promoting endogenous regrowth and healing of damaged or diseased cardiac tissues, said method comprising contacting said damaged or diseased tissues with a composition comprising submucosal tissue of a warm blooded vertebrate.
Claim 2
Independent Claim
34 words
A method for promoting endogenous regrowth and healing of damaged or diseased cardiac tissues, said method comprising contacting said damaged or diseased tissues with a composition comprising submucosal tissue of a warm blooded vertebrate.
Claim 3
Dependent Claim
31 words
The method of claim 1 wherein the step of contacting the damaged or diseased cardiac tissues comprises surgically implanting a patch of submucosal tissue at the site in need of repair.
Claim 4
Dependent Claim
22 words
The method of claim 2 wherein the submucosal tissue is conditioned so that the tissue has a strain of less than 30%.
Claim 5
Dependent Claim
23 words
The method of claim 2 wherein the submucosal tissue is conditioned so that the tissue has a strain of no more than 20%.
Claim 6
Dependent Claim
27 words
The method of claim 1 wherein the submucosal tissue is fluidized and the fluidized tissue is injected into or adjacent to said damaged or diseased cardiac tissues.
Claim 7
Dependent Claim
38 words
The, method of claim 2 wherein the submucosal tissue is implanted into the atrial and ventricular myocardium to remodel into myocadial tissue that functions as an A-V bridge for conducting excitation from the S-A node to the ventricles.
Claim 8
Dependent Claim
36 words
An article of manufacture comprising intestinal submucosa and a support wherein the intestinal submucosa is conditioned to have a strain of less than 30% and the support holds and maintains the tissue in its conditioned state.
Claim 9
Dependent Claim
36 words
An article of manufacture comprising intestinal submucosa and a support wherein the intestinal submucosa is conditioned to have a strain of less than 30% and the support holds and maintains the tissue in its conditioned state.
Claim 10
Dependent Claim
16 words
The article of manufacture of claim 7 wherein the intestinal submucosa and the support are sterilized.
Claim 11
Dependent Claim
25 words
The article of manufacture of claim 8 further comprising a sealed container that encloses and maintains the sterility of said intestinal submucosa and said support.
Claim 12
Dependent Claim
31 words
The article of manufacture of claim 7 wherein the intestinal submucosa comprises the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portions of the tunica mucosa.
Claim 13
Dependent Claim
34 words
The article of manufacture of claim 7 wherein the support is a spool and the intestinal submucosa is wrapped onto the spool under sufficient tension to maintain the intestinal submucosa in its conditioned state.
Claim 14
Dependent Claim
34 words
The article of manufacture of claim 7 wherein the support is a frame having opposite sides for holding said intestinal submucosa, wherein said opposite sides are held in fixed position relative to one another.
Claim 15
Dependent Claim
19 words
The article of manufacture of claim 12 wherein at least one of the opposite sides further comprises a clamp.
Claim 16
Dependent Claim
31 words
The article of manufacture of claim 9 wherein the intestinal submucosa comprises the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portions of the tunica mucosa.
Claim 17
Dependent Claim
34 words
The article of manufacture of claim 9 wherein the support is a spool and the intestinal submucosa is wrapped onto the spool under sufficient tension to maintain the intestinal submucosa in its conditioned state.
Claim 18
Dependent Claim
34 words
The article of manufacture of claim 9 wherein the support is a frame having opposite sides for holding said intestinal submucosa, wherein said opposite sides are held in fixed position relative to one another.
Claim 19
Dependent Claim
28 words
The method of claim 1 wherein the submucosal tissue comprises intestinal submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunics mucosa.
Claim 20
Dependent Claim
39 words
An article of manufacture comprising submucosal tissue of a warm blooded vertebrate and a support wherein the submucosal tissue is conditioned to have a strain of less than 30% and the support holds the tissue in its conditioned state.
Claim 21
Dependent Claim
39 words
An article of manufacture comprising submucosal tissue of a warm blooded vertebrate and a support wherein the submucosal tissue is conditioned to have a strain of less than 30% and the support holds the tissue in its conditioned state.
Claim 22
Dependent Claim
16 words
The article of manufacture of claim 18 wherein the submucosal tissue and the support are sterilized.
Claim 23
Dependent Claim
25 words
The article of manufacture of claim 19 further comprising a sealed container that encloses and maintains the sterility of said submucosal tissue and said support.
Claim 24
Dependent Claim
31 words
The article of manufacture of claim 18 wherein the submucosal tissue comprises the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa.
Claim 25
Dependent Claim
34 words
The article of manufacture of claim 18 wherein the support is a spool and the submucosal tissue is wrapped onto the spool under sufficient tension to maintain the submucosal tissue in its conditioned state.
Claim 26
Dependent Claim
31 words
The article of manufacture of claim 18 wherein the support is a frame having opposite sides for holding said submucosal tissue, wherein said opposite sides are held in a spaced-apart relationship.
Claim 27
Dependent Claim
19 words
The article of manufacture of claim 23 wherein at least one of the opposite sides further comprises a clamp.
Claim 28
Dependent Claim
31 words
The article of manufacture of claim 20 wherein the submucosal tissue comprises the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portions of the tunica mucosa.
Claim 29
Dependent Claim
34 words
The article of manufacture of claim 20 wherein the support is a spool and the submucosal tissue is wrapped onto the spool under sufficient tension to maintain the submucosal tissue in its conditioned state.
Claim 30
Dependent Claim
31 words
The article of manufacture of claim 20 wherein the support is a frame having opposite sides for holding said submucosal tissue, wherein said opposite sides are held in a spaced-apart relationship.
References Cited (Backward Citations)
US5480424A
Cited
WO1996031157A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-01 | 2004-01-31 | 2004-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-01 | 2008-01-31 | 2008-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-01 | 2012-01-31 | 2012-08-01 | $7700.00 | Window Closed / Lapsed |