US5755791A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perforated submucosal tissue graft constructs
Assignee: Methodist Hospital
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Filing: 1996-04-05
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Granted: 1998-05-26
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Expires: 2016-04-05
Abstract
Abstract A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
Inventors
- 👤 Bryan Whitson
- 👤 Boyle Cheng
- 👤 Stephen F. Badylak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:32
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61F; A61F2/00; A61F2/02; A61L27/3604; A61L27/3629; A61F2240/00; A61F2240/001
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
98 words
A unitary multi-laminate tissue graft construct comprising multiple strips of intestinal submucosa, wherein each of said multiple strips has first and second planar surfaces and each is delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, said graft construct formed to have a planar surface with a surface area greater than the surface area of any one planar surface of the individual strips used to form said construct, said graft further provided with a plurality of perforations that allow fluid to pass through the craft construct.
Claim 2
Dependent Claim
98 words
A unitary multi-laminate tissue graft construct comprising multiple strips of intestinal submucosa, wherein each of said multiple strips has first and second planar surfaces and each is delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa of a warm blooded vertebrate, said graft construct formed to have a planar surface with a surface area greater than the surface area of any one planar surface of the individual strips used to form said construct, said graft further provided with a plurality of perforations that allow fluid to pass through the craft construct.
Claim 3
Dependent Claim
33 words
The graft construct of claim 1, wherein each of the perforations define a longitudinal perforation axis and each perforation is formed such that the perforation axis is not perpendicular to the planar surface.
Claim 4
Dependent Claim
13 words
The graft construct of claim 1, formed as a unitary heterolaminar graft construct.
Claim 5
Dependent Claim
13 words
The graft construct of claim 1, formed as a unitary homolaminar graft construct.
Claim 6
Dependent Claim
21 words
The graft construct of claim 1, wherein the submucosa strips are conditioned to have a strain of no more than 20%.
Claim 7
Dependent Claim
19 words
The graft construct of claim 1, wherein the perforations are uniformly distributed over the surfaces of the graft construct.
Claim 8
Dependent Claim
24 words
The graft construct of claim 1, wherein the perforations are spaced from one another at a distance of about 2 to about 20 mm.
Claim 9
Dependent Claim
19 words
The graft construct of claim 7, wherein the perforations are uniformly distributed over the surfaces of the graft construct.
Claim 10
Dependent Claim
24 words
The graft construct of claim 1, wherein the perforations are of substantially uniform size and have a diameter of about 0.5 to 3 mm.
Claim 11
Dependent Claim
31 words
The tissue graft construct of claim 1, wherein the strips of intestinal submucosa tissue consist essentially of the tunica submucosa, the muscularis mucosa and the stratum compactum of the tunica mucosa.
Claim 12
Dependent Claim
26 words
The tissue graft construct of claim 1, wherein the strips of submucosa tissue forming said construct are orientated so that the construct has substantially isotropic properties.
References Cited (Backward Citations)
US2127903A
Cited
US3562820A
Cited
US4729766A
Cited
US5002572A
Cited
US5350583A
Cited
US4902508A
Cited
US4956178A
Cited
US5219361A
Cited
US5306304A
Cited
US5455100A
Cited
US5371821A
Cited
US5281422A
Cited
US5496372A
Cited
US5352463A
Cited
US5275826A
Cited
WO1995006439A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-05-25 | 2001-11-24 | 2002-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-05-25 | 2005-11-24 | 2006-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-05-25 | 2009-11-24 | 2010-05-26 | $7700.00 | Window Closed / Lapsed |