US5885619A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Large area submucosal tissue graft constructs and method for making the same
Assignee: Methodist Hospital
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Filing: 1997-09-16
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Granted: 1999-03-23
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Expires: 2017-09-16
Abstract
Abstract A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.
Inventors
- 👤 Umesh H. Patel
- 👤 Michael C. Hiles
- 👤 Bryan Whitson
- 👤 Boyle Cheng
- 👤 Stephen F. Badylak
- 👤 Klod Kokini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:05
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61F; A61F2/00; A61F2/0063; A61K; A61K35/00; A61K35/12; A61K35/37; A61K35/38; A61L27/3604; A61L27/3629; A61P; A61P43/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
82 words
A method for forming a unitary tissue graft construct consisting essentially of multiple strips of submucosal tissue, said construct having a surface area greater than any one of the individual strips used to form said construct, said method comprising the steps of overlapping a portion of one strip of submucosal tissue with a portion of a second strip of submucosal tissue and compressing at least the overlapped portions between two surfaces, at least one of which is water permeable, under dehydrating conditions.
Claim 2
Independent Claim
82 words
A method for forming a unitary tissue graft construct consisting essentially of multiple strips of submucosal tissue, said construct having a surface area greater than any one of the individual strips used to form said construct, said method comprising the steps of overlapping a portion of one strip of submucosal tissue with a portion of a second strip of submucosal tissue and compressing at least the overlapped portions between two surfaces, at least one of which is water permeable, under dehydrating conditions.
Claim 3
Dependent Claim
20 words
The method of claim 1, further comprising the step of applying a vacuum to the submucosal tissue during compression thereof.
Claim 4
Dependent Claim
19 words
The method of claim 2, wherein the applied vacuum coacts with the two surfaces to compress the submucosal tissue.
Claim 5
Dependent Claim
19 words
The method of claim 1, further comprising the step of applying heat to the submucosal tissue during compression thereof.
Claim 6
Dependent Claim
11 words
The method of claim 1, wherein both surfaces are water permeable.
Claim 7
Dependent Claim
30 words
The method of claim 1, wherein the two surfaces are complementary nonplanar surfaces wherein compression between the two surfaces produces a tissue graft construct shaped to conform to those surfaces.
Claim 8
Dependent Claim
32 words
The method of claim 1, wherein the submucosal tissue is intestinal submucosa comprising the tunica submucosa delaminated from both the tunica muscularis and at least the luminal portion of the tunica mucosa.
Claim 9
Dependent Claim
40 words
The method of claim 1 farther comprising the step of moving a compressing force across the surface of the construct to remove air and bulk water trapped between the overlapped strips before compressing the overlapped portions between the two surfaces.
Claim 10
Dependent Claim
24 words
The method of claim 8, wherein the two surfaces comprise a pair of opposed rollers and the overlapped strips are passed between the rollers.
Claim 11
Dependent Claim
128 words
A large area multi-laminate sheet of submucosal tissue comprising multiple strips of intestinal submucosal tissue delaminated from both the tunica muscularis and at least the lurninal portion of the tunica mucosa of a warm blooded vertebrate, said strips having an abluminal surface and a lurinal surface, wherein each strip is partially overlapped with at least one additional strip of submucosal tissue and the the luminal surface of each strip is in contact with the abluminal surface of at least one additional strip of submucosal tissue, said multiple strips of intestinal submucosa tissue being fused to one another by compressing the strips under dehydrating conditions to form a sheet of submucosal tissue having a surface area greater than any one of the individual strips used to form said construct.
Claim 12
Dependent Claim
128 words
A large area multi-laminate sheet of submucosal tissue comprising multiple strips of intestinal submucosal tissue delaminated from both the tunica muscularis and at least the lurninal portion of the tunica mucosa of a warm blooded vertebrate, said strips having an abluminal surface and a lurinal surface, wherein each strip is partially overlapped with at least one additional strip of submucosal tissue and the the luminal surface of each strip is in contact with the abluminal surface of at least one additional strip of submucosal tissue, said multiple strips of intestinal submucosa tissue being fused to one another by compressing the strips under dehydrating conditions to form a sheet of submucosal tissue having a surface area greater than any one of the individual strips used to form said construct.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-03-22 | 2002-09-21 | 2003-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-03-22 | 2006-09-21 | 2007-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-03-22 | 2010-09-21 | 2011-03-23 | $7700.00 | Window Closed / Lapsed |