US6473639B1 — Neurological event detection procedure using proc…

Claim 1

Independent Claim 185 words

A device for detection of neurological event activity in a patient's brain comprising: at least one brain electrode configured to monitor brain electrical signals and produce an output, each said brain electrode being positionable to a position relative to a patient's brain, at least one processed display channel processor configured to produce at least one processed display channel, said at least one processed display channel being a signal produced by signal processing by said at least one processed display channel processor, of a digital signal related to said output from said at least one brain electrode, the signal processing having one or more parameters; a neurological event detector configured to process the at least one processed display channel with at least one detector algorithm to detect neurological event activity based upon i.) the brain electrical signals received by the at least one brain electrode, ii.) the position of each brain electrode, iii.) the parameters of the signal processing used to create the at least one processed display channel, iv.) and at least one detector algorithms having at least one detector parameter customizeable for each patient.

Claim 2

Independent Claim 185 words

A device for detection of neurological event activity in a patient's brain comprising: at least one brain electrode configured to monitor brain electrical signals and produce an output, each said brain electrode being positionable to a position relative to a patient's brain, at least one processed display channel processor configured to produce at least one processed display channel, said at least one processed display channel being a signal produced by signal processing by said at least one processed display channel processor, of a digital signal related to said output from said at least one brain electrode, the signal processing having one or more parameters; a neurological event detector configured to process the at least one processed display channel with at least one detector algorithm to detect neurological event activity based upon i.) the brain electrical signals received by the at least one brain electrode, ii.) the position of each brain electrode, iii.) the parameters of the signal processing used to create the at least one processed display channel, iv.) and at least one detector algorithms having at least one detector parameter customizeable for each patient.

Claim 3

Dependent Claim 23 words

The device of claim 1 wherein said at least one brain electrode is configured to accept electrical stimulation signals for the patient's brain.

Claim 4

Dependent Claim 21 words

The device of claim 1 further comprising conductors to carry electrical signals to and from the at least one brain electrode.

Claim 5

Dependent Claim 30 words

The device of claim 1 further comprising an amplifier configured to amplify the electrical signals from the at least one brain electrode to produce at least one amplified electrical signal.

Claim 6

Dependent Claim 28 words

The device of claim 4 further comprising an analog-to-digital converter configured to convert the at least one amplified electrical signal to produce said at least one digital signal.

Claim 7

Dependent Claim 13 words

The device of claim 1 wherein the neurological event activity is epileptiform activity.

Claim 8

Dependent Claim 33 words

The device of claim 1 further comprising a signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by low pass filtering.

Claim 9

Dependent Claim 33 words

The device of claim 1 further comprising a signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by high pass filtering.

Claim 10

Dependent Claim 32 words

The device of claim 1 further comprising a signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by bandpass filtering.

Claim 11

Dependent Claim 48 words

The device of claim 1 further comprising a signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by the summing of two or more of the digital signals each digital signal multiplied by a weighting factor.

Claim 12

Dependent Claim 41 words

The device of claim 1 further comprising a signal processor for the signal processing of one or more of the digital signals to produce a processed display channel by the subtraction of at least one of the digital signals from another.

Claim 13

Dependent Claim 28 words

The device of claim 11 wherein in said subtraction of at least one of the digital signals from another, each digital signal is multiplied by a weighting factor.

Claim 14

Dependent Claim 52 words

The device of claim 1 wherein the neurological event detector device is further configured to process the at least one processed display channel and to detect neurological event activity based upon two or more detection algorithms that may be used concurrently to identify neurological event activity from a single processed display channel.

Claim 15

Dependent Claim 16 words

The device of claim 1 wherein said device is a workstation external to the patient's body.

Claim 16

Dependent Claim 61 words

The device of claim 1 wherein said at least one display device displays a first and a second processed display channel wherein said first processed display channel has at least one detection algorithm being chosen to detect the precursor of a seizure and said second processed display channel has at least one detection algorithm being chosen to detect ongoing in-seizure activity.

Claim 17

Dependent Claim 24 words

The device of claim 1 wherein said at least one display device displays electrical signal from the brain electrodes and the processed display channels.

Claim 18

Dependent Claim 20 words

The device of claim 1 further comprising an electrical stimulation therapy device implantable under the skin of a human body.

Claim 19

Dependent Claim 20 words

The device of claim 1 further comprising an electrical stimulation therapy device implantable under the scalp of a human body.

Claim 20

Dependent Claim 20 words

The device of claim 1 further comprising an electrical stimulation therapy device implantable into the cranium of a human body.

Claim 21

Dependent Claim 46 words

The device of claim 1 wherein the neurological event detector is configured to apply an amplitude duration detector algorithm to said at least one processed display channel for detecting an increase in signal amplitude in said at least one processed display channel for a specified time.

Claim 22

Dependent Claim 44 words

The device of claim 1 wherein the neurological event detector is configured to apply a DC shift algorithm to said at least one processed display channel for detecting a shift in the DC level of the processed display channel occurring over a specified time.

Claim 23

Dependent Claim 53 words

The device of claim 1 wherein the neurological event detector is configured to apply a zero crossing detector algorithm to said at least one processed display channel for detecting epileptiform activity when the number of zero crossings of said processed display channel is within a chosen range over a chosen length of time.

Claim 24

Dependent Claim 30 words

The device of claim 22 wherein the zero crossing detector algorithm also compares the average of the maximum and minimum amplitudes between the zero crossings with a chosen amplitude threshold.

Claim 25

Dependent Claim 57 words

The device of claim 1 wherein the neurological event detector is configured to apply a waveform detector algorithm to said at least one processed display channel for detecting when the number of half waves of a specified amplitude and minimum duration of said at least one processed display channel exceeds a preset limit over a chosen time.

Claim 26

Dependent Claim 22 words

The device of claim 24 wherein the settable parameter is the number of waves being exactly twice the number of half waves.

Claim 27

Dependent Claim 39 words

The device of claim 1 wherein the neurological event detector device is configured concurrently to apply two or more detection algorithms to different processed display channels to identify neurological event activity in each of said different processed display channels.

Claim 28

Dependent Claim 13 words

The device of claim 26 wherein the neurological event activity is epileptiform activity.

Claim 29

Dependent Claim 39 words

The device of claim 1 wherein the neurological event detector device is configured concurrently to apply two or more detection algorithms to different processed display channels to identify neurological event activity in two or more different processed display channels.

Claim 30

Dependent Claim 13 words

The device of claim 28 wherein the neurological event activity is epileptiform activity.

Claim 31

Dependent Claim 39 words

The device of claim 1 further comprising a seizure detection logic module configured to declare a valid seizure detection based on logical operations performed on the occurrence of a valid seizure detection in two or more processed display channels.

Claim 32

Dependent Claim 32 words

The device of claim 30 wherein said seizure detection logic module is configured to require that a seizure be detected in all processed display channels before declaring the seizure to be valid.

Claim 33

Dependent Claim 32 words

The device of claim 30 wherein said seizure detection logic module is configured to require that a seizure be detected in any processed display channel before declaring the seizure to be valid.

Claim 34

Dependent Claim 42 words

The device of claim 30 wherein seizure detection logic module is configured to require that a seizure be detected in a first processed display channel but not be detected in a second processed display channel before declaring the seizure to be valid.

Claim 35

Dependent Claim 19 words

The device of claim 1 wherein said detector algorithm is selected to reflect a neurological event in said patient.

Claim 36

Dependent Claim 32 words

The device of claim 1 wherein the detector algorithm is derived by detecting a neurological event in a specific human patient and forming said detector algorithm to detect that neurological event activity.

Claim 37

Dependent Claim 117 words

An implantable neuropacemaker assembly comprising: a multiplicity of intracranially placeable leads for delivering electrocortigram signals; at least one amplifier for amplifying the electrocortigram signals and produce amplified electrocortigram signals; at least one analog-to-digital converter for digitizing the amplified electrocortigram signals to produce a multiplicity of digital signals; at least one signal processor configured to produce one or more processed display channels, each processed display channel being a signal produced by the combination of one or more of the multiplicity of digital signals by signal processing with an algorithm having signal processing parameters; and at least one epileptiform event detector device configured to process said one or more processed display channel with programmable algorithms to detect epileptiform activity.

Claim 38

Dependent Claim 117 words

An implantable neuropacemaker assembly comprising: a multiplicity of intracranially placeable leads for delivering electrocortigram signals; at least one amplifier for amplifying the electrocortigram signals and produce amplified electrocortigram signals; at least one analog-to-digital converter for digitizing the amplified electrocortigram signals to produce a multiplicity of digital signals; at least one signal processor configured to produce one or more processed display channels, each processed display channel being a signal produced by the combination of one or more of the multiplicity of digital signals by signal processing with an algorithm having signal processing parameters; and at least one epileptiform event detector device configured to process said one or more processed display channel with programmable algorithms to detect epileptiform activity.

Claim 39

Dependent Claim 34 words

The implantable neuropacemaker assembly of claim 36 wherein said signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by low pass filtering.

Claim 40

Dependent Claim 34 words

The implantable neuropacemaker assembly of claim 36 wherein said signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by high pass filtering.

Claim 41

Dependent Claim 33 words

The implantable neuropacemaker assembly of claim 36 wherein said signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by bandpass filtering.

Claim 42

Dependent Claim 41 words

The implantable neuropacemaker assembly of claim 36 wherein said signal processor for the signal processing of said one or more of the digital signals to produce a processed display channel by the summing of two or more of the digital signals.

Claim 43

Dependent Claim 30 words

The implantable neuropacemaker assembly of claim 38 wherein in said summing of at least one of the digital signals with another, each digital signal is multiplied by a weighting factor.

Claim 44

Dependent Claim 42 words

The implantable neuropacemaker assembly of claim 36 wherein said signal processor for the signal processing of one or more of the digital signals to produce a processed display channel by the subtraction of at least one of the digital signals from another.

Claim 45

Dependent Claim 30 words

The implantable neuropacemaker assembly of claim 42 wherein in said subtraction of at least one of the digital signals from another, each digital signal is multiplied by a weighting factor.

Claim 46

Dependent Claim 54 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector device is further configured to process the at least one processed display channel and to detect epileptiform event activity based upon two or more detection algorithms that may be used concurrently to identify epileptiform event activity from a single processed display channel.

Claim 47

Dependent Claim 64 words

The implantable neuropacemaker assembly of claim 36 wherein said epileptiform event detector is configured to produce a first and a second processed display channel wherein said first processed display channel has at least one detection algorithm being chosen to detect the precursor of a seizure and said second processed display channel has at least one detection algorithm being chosen to detect ongoing in-seizure activity.

Claim 48

Dependent Claim 17 words

The implantable neuropacemaker assembly of claim 36 configured for implantation under the skin of a human body.

Claim 49

Dependent Claim 17 words

The implantable neuropacemaker assembly of claim 36 configured for implantation under the scalp of a human body.

Claim 50

Dependent Claim 17 words

The implantable neuropacemaker assembly of claim 37 configured for implantation into the cranium of a human body.

Claim 51

Dependent Claim 48 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector is configured to apply an amplitude duration detector algorithm to said at least one processed display channel for detecting an increase in signal amplitude in said at least one processed display channel for a specified time.

Claim 52

Dependent Claim 46 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector is configured to apply a DC shift algorithm to said at least one processed display channel for detecting a shift in the DC level of the processed display channel occurring over a specified time.

Claim 53

Dependent Claim 55 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector is configured to apply a zero crossing detector algorithm to said at least one processed display channel for detecting epileptiform activity when the number of zero crossings of said processed display channel is within a chosen range over a chosen length of time.

Claim 54

Dependent Claim 32 words

The implantable neuropacemaker assembly of claim 51 wherein the zero crossing detector algorithm also compares the average of the maximum and minimum amplitudes between the zero crossings with a chosen amplitude threshold.

Claim 55

Dependent Claim 59 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector is configured to apply a waveform detector algorithm to said at least one processed display channel for detecting when the number of half waves of a specified amplitude and minimum duration of said at least one processed display channel exceeds a preset limit over a chosen time.

Claim 56

Dependent Claim 24 words

The implantable neuropacemaker assembly of claim 53 wherein the settable parameter is the number of waves being exactly twice the number of half waves.

Claim 57

Dependent Claim 41 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector device is configured concurrently to apply two or more detection algorithms to different processed display channels to identify epileptiform event activity in each of said different processed display channels.

Claim 58

Dependent Claim 41 words

The implantable neuropacemaker assembly of claim 36 wherein the epileptiform event detector device is configured concurrently to apply two or more detection algorithms to different processed display channels to identify epileptiform event activity in two or more different processed display channels.

Claim 59

Dependent Claim 41 words

The implantable neuropacemaker assembly of claim 36 further comprising a seizure detection logic module configured to declare a valid seizure detection based on logical operations performed on the occurrence of a valid seizure detection in two or more processed display channels.

Claim 60

Dependent Claim 34 words

The implantable neuropacemaker assembly of claim 57 wherein said seizure detection logic module is configured to require that a seizure be detected in all processed display channels before declaring the seizure to be valid.

Claim 61

Dependent Claim 34 words

The implantable neuropacemaker assembly of claim 57 wherein said seizure detection logic module is configured to require that a seizure be detected in any processed display channel before declaring the seizure to be valid.

Claim 62

Dependent Claim 44 words

The implantable neuropacemaker assembly of claim 57 wherein seizure detection logic module is configured to require that a seizure be detected in a first processed display channel but not be detected in a second processed display channel before declaring the seizure to be valid.

Claim 63

Dependent Claim 30 words

The device of claim 36 wherein the detector algorithm is derived by detecting epileptiform activity in a specific human patient and forming said programmable algorithm to detect that epileptiform activity.

Claim 64

Independent Claim 141 words

A device for detecting an epileptiform activity from a multiplicity of digitized EEG signals comprising: at least one processed display channel processor configured to produce at least one processed display channel by signal processing of at least one of the multiplicity of digitized EEG signals, said signal processing having one or more parameters; at least one epileptiform activity detector having at least one detector algorithm operating on the at least one processed display channel, the epileptiform activity detector having at least one programmable detection parameter, the epileptiform activity detector being configured to detect epileptiform activity based upon i.) the at least one processed display channel signal, ii.) the parameters of the signal processing used to create the at least one processed display channel, and iii.) said at least one detector algorithm having at least one detector parameter customizable for each patient.

Claim 65

Independent Claim 141 words

A device for detecting an epileptiform activity from a multiplicity of digitized EEG signals comprising: at least one processed display channel processor configured to produce at least one processed display channel by signal processing of at least one of the multiplicity of digitized EEG signals, said signal processing having one or more parameters; at least one epileptiform activity detector having at least one detector algorithm operating on the at least one processed display channel, the epileptiform activity detector having at least one programmable detection parameter, the epileptiform activity detector being configured to detect epileptiform activity based upon i.) the at least one processed display channel signal, ii.) the parameters of the signal processing used to create the at least one processed display channel, and iii.) said at least one detector algorithm having at least one detector parameter customizable for each patient.

Claim 66

Dependent Claim 39 words

The device of claim 62 wherein the at least one processed display channel processor for the signal processing of the at least one of the multiplicity of digitized EEG signals produces a processed display channel by low pass filtering.

Claim 67

Dependent Claim 39 words

The device of claim 62 wherein the at least one processed display channel processor for the signal processing of the at least one of the multiplicity of digitized EEG signals produces a processed display channel by high pass filtering.

Claim 68

Dependent Claim 38 words

The device of claim 62 wherein the at least one processed display channel processor for the signal processing of the at least one of the multiplicity of digitized EEG signals produces a processed display channel by bandpass filtering.

Claim 69

Dependent Claim 46 words

The device of claim 62 wherein the at least one processed display channel processor for the signal processing of the at least one of the multiplicity of digitized EEG signals produces a processed display channel by summing of two or more of the digitized EEG signals.

Claim 70

Dependent Claim 34 words

The device of claim 66 wherein in said summing of the at least one of the multiplicity of digitized EEG signals with each another, each digitized EEG signal is multiplied by a weighting factor.

Claim 71

Dependent Claim 49 words

The device of claim 62 wherein the at least one processed display channel processor for the signal processing of the at least one of the multiplicity of digitized EEG signals produces a processed display channel by the subtraction of at least one of the digitized EEG signals from another.

Claim 72

Dependent Claim 30 words

The device of claim 68 wherein in said subtraction of at least one of the digitized EEG signals from another, each digitized EEG signal is multiplied by a weighting factor.

Claim 73

Dependent Claim 49 words

The device of claim 62 wherein the epileptiform activity detector is further configured to process the at least one processed display channel and to detect epileptiform activity based upon two or more detection algorithms that may be used concurrently to identify epileptiform activity from a single processed display channel.

Claim 74

Dependent Claim 62 words

The device of claim 62 wherein said epileptiform activity detector is configured to produce a first and a second processed display channel wherein said first processed display channel has at least one detection algorithm being chosen to detect the precursor of a seizure and said second processed display channel has at least one detection algorithm being chosen to detect ongoing in-seizure activity.

Claim 75

Dependent Claim 16 words

The device of claim 62 wherein said device is a workstation external to the patient's body.

Claim 76

Dependent Claim 19 words

The device of claim 72 wherein the workstation is configured to display digitized EEG signals and processed display channels.

Claim 77

Dependent Claim 15 words

The device of claim 62 configured for implantation under the skin of a human body.

Claim 78

Dependent Claim 15 words

The device of claim 62 configured for implantation under the scalp of a human body.

Claim 79

Dependent Claim 15 words

The device of claim 62 configured for implantation into the cranium of a human body.

Claim 80

Dependent Claim 46 words

The device of claim 62 wherein the epileptiform activity detector is configured to apply an amplitude duration detector algorithm to said at least one processed display channel for detecting an increase in signal amplitude in said at least one processed display channel for a specified time.

Claim 81

Dependent Claim 44 words

The device of claim 62 wherein the epileptiform activity detector is configured to apply a DC shift algorithm to said at least one processed display channel for detecting a shift in the DC level of the processed display channel occurring over a specified time.

Claim 82

Dependent Claim 53 words

The device of claim 62 wherein the epileptiform activity detector is configured to apply a zero crossing detector algorithm to said at least one processed display channel for detecting epileptiform activity when the number of zero crossings of said processed display channel is within a chosen range over a chosen length of time.

Claim 83

Dependent Claim 30 words

The device of claim 79 wherein the zero crossing detector algorithm also compares the average of the maximum and minimum amplitudes between the zero crossings with a chosen amplitude threshold.

Claim 84

Dependent Claim 57 words

The device of claim 62 wherein the epileptiform activity detector is configured to apply a waveform detector algorithm to said at least one processed display channel for detecting when the number of half waves of a specified amplitude and minimum duration of said at least one processed display channel exceeds a preset limit over a chosen time.

Claim 85

Dependent Claim 22 words

The device of claim 81 wherein the settable parameter is the number of waves being exactly twice the number of half waves.

Claim 86

Dependent Claim 38 words

The device of claim 62 wherein the epileptiform activity detector device is configured concurrently to apply two or more detection algorithms to different processed display channels to identify epileptiform activity in each of said different processed display channels.

Claim 87

Dependent Claim 39 words

The device of claim 62 wherein the epileptiform activity detector device is configured concurrently to apply two or more detection algorithms to different processed display channels to identify epileptiform event activity in two or more different processed display channels.

Claim 88

Dependent Claim 39 words

The device of claim 62 further comprising a seizure detection logic module configured to declare a valid seizure detection based on logical operations performed on the occurrence of a valid seizure detection in two or more processed display channels.

Claim 89

Dependent Claim 32 words

The device of claim 85 wherein said seizure detection logic module is configured to require that a seizure be detected in all processed display channels before declaring the seizure to be valid.

Claim 90

Dependent Claim 32 words

The device of claim 85 wherein said seizure detection logic module is configured to require that a seizure be detected in any processed display channel before declaring the seizure to be valid.

Claim 91

Dependent Claim 42 words

The device of claim 85 wherein seizure detection logic module is configured to require that a seizure be detected in a first processed display channel but not be detected in a second processed display channel before declaring the seizure to be valid.

Claim 92

Dependent Claim 19 words

The device of claim 62 wherein said detector algorithm is selected to reflect a neurological event in said patient.

Claim 93

Dependent Claim 30 words

The device of claim 62 wherein the detector algorithm is derived by detecting epileptiform activity in a specific human patient and forming said detector algorithm to detect that epileptiform activity.

Claim 94

Independent Claim 203 words

A device for diagnosis of, testing for, and treatment of epileptic seizures of a human patient, the device comprising: a multiplicity of brain electrodes configured to receive neural electrical signals generated by the brain of the human patient; conductors for carrying electrical signals to and from the multiplicity of brain electrodes; a physician's workstation configured to detect the presence of epileptiform activity by signal processing of at least one electrical signal received by the multiplicity of brain electrodes, the signal processing including analyzing a processed display channel using a processed display channel based seizure detector, the processed display channel based seizure detector having seizure detector parameters adjustable by a user best to detect epileptiform activity for a selected human patient; an implantable neuropacemaker configured to detect the presence of epileptiform activity by processing of at least one electrical signal received by the multiplicity of brain electrodes into at least one processed display channel and analysis of the at least one processed display channel for epileptiform activity using seizure detector having seizure detector parameters; and a transmitter configured to transmit to the neuropacemaker, the seizure detector parameters from the physician's workstation that have been selected to detect the epileptiform activity for the human patient.

Claim 95

Independent Claim 203 words

A device for diagnosis of, testing for, and treatment of epileptic seizures of a human patient, the device comprising: a multiplicity of brain electrodes configured to receive neural electrical signals generated by the brain of the human patient; conductors for carrying electrical signals to and from the multiplicity of brain electrodes; a physician's workstation configured to detect the presence of epileptiform activity by signal processing of at least one electrical signal received by the multiplicity of brain electrodes, the signal processing including analyzing a processed display channel using a processed display channel based seizure detector, the processed display channel based seizure detector having seizure detector parameters adjustable by a user best to detect epileptiform activity for a selected human patient; an implantable neuropacemaker configured to detect the presence of epileptiform activity by processing of at least one electrical signal received by the multiplicity of brain electrodes into at least one processed display channel and analysis of the at least one processed display channel for epileptiform activity using seizure detector having seizure detector parameters; and a transmitter configured to transmit to the neuropacemaker, the seizure detector parameters from the physician's workstation that have been selected to detect the epileptiform activity for the human patient.

Claim 96

Dependent Claim 29 words

The device of claim 91 further comprising a neural stimulator controller configured to initiate electrical stimulation to one or more of said brain electrodes upon detection of epileptiform activity.

Claim 97

Independent Claim 141 words

A device for detection of epileptiform activity from a patient's brain comprising: at least one brain electrode, an amplifier, a digital to analog converter, and a processed display channel processor, wherein said at least one brain electrode is configured to electronically communicate signal information from a patient's brain to said amplifier, said amplifier being configured to amplify said signal information and produce amplified signals, wherein said analog to digital converter is configured to electronically receive said amplified signals from said amplifier and convert said amplified signals to digital signals, wherein said processed display channel processor is configured to process said multiple digital signals with an algorithm according to programmable algorithm rules to produce a processed display channel signal, said programmable algorithm rules being configured to produce a processed display channel signal clearly exhibiting characteristics of epileptiform activity within the patient's brain.

Claim 98

Independent Claim 141 words

A device for detection of epileptiform activity from a patient's brain comprising: at least one brain electrode, an amplifier, a digital to analog converter, and a processed display channel processor, wherein said at least one brain electrode is configured to electronically communicate signal information from a patient's brain to said amplifier, said amplifier being configured to amplify said signal information and produce amplified signals, wherein said analog to digital converter is configured to electronically receive said amplified signals from said amplifier and convert said amplified signals to digital signals, wherein said processed display channel processor is configured to process said multiple digital signals with an algorithm according to programmable algorithm rules to produce a processed display channel signal, said programmable algorithm rules being configured to produce a processed display channel signal clearly exhibiting characteristics of epileptiform activity within the patient's brain.

Claim 99

Dependent Claim 140 words

An implantable neuropacemaker comprising: at least one intracranially placed lead, an amplifier, an analog to digital converter, a signal processor, and an epileptiform activity detector module, said intracranially placed lead being configured to receive EEG signals from the brain of a patient and transmit said signals to said amplifier, said amplifier being configured to amplify said signals and produce amplified signals, said analog to digital converter being configured to electronically receive said amplified signals and convert said amplified signals to a multiplicity of digital signals, said signal processor being configured to process said multiple digital signals according to programmable parameters to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain, said epileptiform activity detector module being configured to detect epileptiform activity based upon processing of said processed display channel signal using a detection algorithm.

Claim 100

Dependent Claim 140 words

An implantable neuropacemaker comprising: at least one intracranially placed lead, an amplifier, an analog to digital converter, a signal processor, and an epileptiform activity detector module, said intracranially placed lead being configured to receive EEG signals from the brain of a patient and transmit said signals to said amplifier, said amplifier being configured to amplify said signals and produce amplified signals, said analog to digital converter being configured to electronically receive said amplified signals and convert said amplified signals to a multiplicity of digital signals, said signal processor being configured to process said multiple digital signals according to programmable parameters to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain, said epileptiform activity detector module being configured to detect epileptiform activity based upon processing of said processed display channel signal using a detection algorithm.

Claim 101

Independent Claim 118 words

A device for detecting an epileptiform activity from a multiplicity of digitized EEG signals comprising: one or more brain electrodes configured to receive EEG signals from the brain of a patient; one or more processed display channel processors to produce processed display channels, each processed display channel comprising one or more EEG signals combined using digital signal processing; an epileptiform activity detector having detector algorithms operating on said one or more processed display channels, the epileptiform activity detector being configured to detect epileptiform activity, wherein the position of each brain electrode, the parameters of the signal processing used to create the processed display channel, and the algorithms used by the epileptiform activity detector being customized for each patient.

Claim 102

Independent Claim 118 words

A device for detecting an epileptiform activity from a multiplicity of digitized EEG signals comprising: one or more brain electrodes configured to receive EEG signals from the brain of a patient; one or more processed display channel processors to produce processed display channels, each processed display channel comprising one or more EEG signals combined using digital signal processing; an epileptiform activity detector having detector algorithms operating on said one or more processed display channels, the epileptiform activity detector being configured to detect epileptiform activity, wherein the position of each brain electrode, the parameters of the signal processing used to create the processed display channel, and the algorithms used by the epileptiform activity detector being customized for each patient.

Claim 103

Independent Claim 201 words

A device for diagnosis, testing, and treatment of epileptic seizures of a human patient, the device comprising: at least one intracranially placed lead, an amplifier, an analog to digital converter, a signal processor, and an epileptiform activity detection module, said intracranially placed lead being configured to receive EEG signals from the brain of a patient and transmit said signals to said amplifier, said amplifier being configured to amplify said signals and produce amplified signals, said analog to digital converter being configured to electronically receive said amplified signals and convert said amplified signals to a multiplicity of digital signals, said signal processor being configured to process said multiple digital signals according to programmable parameters to produce a processed display channel signal, said programmable parameters being configured to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain, said epileptiform activity detection module being configured to detect epileptiform activity based upon processing of said processed display channel signal; said amplifier, analog to digital converter, signal processor, and epileptiform activity detection algorithm comprising an implantable neuropacemaker module; said device further comprising a physician's workstation configured to transmit said programmable parameters to said implantable neuropacemaker module using a communication device.

Claim 104

Independent Claim 201 words

A device for diagnosis, testing, and treatment of epileptic seizures of a human patient, the device comprising: at least one intracranially placed lead, an amplifier, an analog to digital converter, a signal processor, and an epileptiform activity detection module, said intracranially placed lead being configured to receive EEG signals from the brain of a patient and transmit said signals to said amplifier, said amplifier being configured to amplify said signals and produce amplified signals, said analog to digital converter being configured to electronically receive said amplified signals and convert said amplified signals to a multiplicity of digital signals, said signal processor being configured to process said multiple digital signals according to programmable parameters to produce a processed display channel signal, said programmable parameters being configured to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain, said epileptiform activity detection module being configured to detect epileptiform activity based upon processing of said processed display channel signal; said amplifier, analog to digital converter, signal processor, and epileptiform activity detection algorithm comprising an implantable neuropacemaker module; said device further comprising a physician's workstation configured to transmit said programmable parameters to said implantable neuropacemaker module using a communication device.

Claim 105

Independent Claim 90 words

A method for diagnosing and treating neurological disorders in a human patient comprising the steps of: signal processing digital signals related to a patient's EEG signals by combining said patient's EEG signals according to programmable parameters to produce processed display channel signals, the programmable parameters being selected to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain; and analyzing said processed display channel signal with an epileptiform activity detection algorithm configured to detect epileptiform activity based upon processing of said processed display channel signal.

Claim 106

Independent Claim 90 words

A method for diagnosing and treating neurological disorders in a human patient comprising the steps of: signal processing digital signals related to a patient's EEG signals by combining said patient's EEG signals according to programmable parameters to produce processed display channel signals, the programmable parameters being selected to produce a processed display channel signal exhibiting characteristics of epileptiform activity within the patient's brain; and analyzing said processed display channel signal with an epileptiform activity detection algorithm configured to detect epileptiform activity based upon processing of said processed display channel signal.

Claim 107

Dependent Claim 63 words

The process of claim 97 additionally comprising the steps of: implanting at least one intracranially placed lead to a configuration wherein said lead receives EEG signals from the brain of the patient and transmits said signals to an amplifier; and amplifying said signals and transmitting them to an analog to digital converter to convert said signals into a multiplicity of said digital signals.

Claim 108

Dependent Claim 14 words

The process of claim 97 wherein said signal processing step comprises low pass filtering.

Claim 109

Dependent Claim 14 words

The process of claim 97 wherein said signal processing step comprises high pass filtering.

Claim 110

Dependent Claim 13 words

The process of claim 97 wherein said signal processing step comprises bandpass filtering.

Claim 111

Dependent Claim 20 words

The process of claim 97 wherein said signal processing step comprises summing of two or more of the digital signals.

Claim 112

Dependent Claim 28 words

The process of claim 102 wherein said signal in said summing of two or more of the digital signals, each digital signal is multiplied by a weighting factor.

Claim 113

Dependent Claim 22 words

The process of claim 97 wherein said signal processing step comprises subtraction of at least one of the digital signals from another.

Claim 114

Dependent Claim 31 words

The process of claim 97 wherein said signal processing step comprises subtraction of at least one of the digital signals from another, each digital signal is multiplied by a weighting factor.

Claim 115

Dependent Claim 34 words

The process of claim 97 wherein said analysis step comprises detecting neurological event activity based upon two or more detection algorithms used concurrently to identify neurological event activity from a single processed display channel.

Claim 116

Dependent Claim 58 words

The process of claim 97 further comprising displaying on a display device a first and a second processed display channel wherein said first processed display channel has an associated detection algorithm being chosen to detect the precursor of a seizure and said second processed display channel has an associated detection algorithm being chosen to detect ongoing in-seizure activity.

Claim 117

Dependent Claim 23 words

The process of claim 107 further comprising displaying on a display device electrical signals from the brain electrodes and the processed display channels.

Claim 118

Dependent Claim 43 words

The process of claim 97 wherein said analyzing step comprises applying an amplitude duration detector algorithm to said at least one processed display channel for detecting an increase in signal amplitude in said at least one processed display channel for a specified time.

Claim 119

Dependent Claim 41 words

The process of claim 97 wherein said analyzing step comprises applying a DC shift algorithm to said at least one processed display channel for detecting a shift in the DC level of the processed display channel occurring over a specified time.

Claim 120

Dependent Claim 50 words

The process of claim 97 wherein said analyzing step comprises applying a zero crossing detector algorithm to said at least one processed display channel for detecting epileptiform activity when the number of zero crossings of said processed display channel is within a chosen range over a chosen length of time.

Claim 121

Dependent Claim 30 words

The process of claim 111 wherein said zero crossing detector algorithm also compares the average of the maximum and minimum amplitudes between the zero crossings with a chosen amplitude threshold.

Claim 122

Dependent Claim 54 words

The process of claim 97 wherein said analyzing step comprises applying a waveform detector algorithm to said at least one processed display channel for detecting when the number of half waves of a specified amplitude and minimum duration of said at least one processed display channel exceeds a preset limit over a chosen time.

Claim 123

Dependent Claim 35 words

The process of claim 97 wherein said analyzing step comprises concurrently applying two or more detection algorithms to different processed display channels to identify neurological event activity in each of said different processed display channels.

Claim 124

Dependent Claim 35 words

The process of claim 97 wherein said analyzing step comprises concurrently applying two or more detection algorithms to different processed display channels to identify neurological event activity in two or more different processed display channels.

Claim 125

Dependent Claim 36 words

The process of claim 97 wherein said analyzing step further comprises declaring a valid seizure detection based on logical operations performed on the occurrence of a valid seizure detection in two or more processed display channels.

Claim 126

Dependent Claim 34 words

The process of claim 97 wherein said analyzing step further comprises declaring a valid seizure detection based on logical operations performed on the occurrence of a valid seizure detection in all processed display channels.

Claim 127

Dependent Claim 34 words

The process of claim 97 wherein said analyzing step further comprises declaring a valid seizure detection based on logical operations performed on the occurrence of a valid seizure detection in any processed display channels.

Claim 128

Dependent Claim 40 words

The process of claim 97 wherein said analyzing step further comprises declaring a valid seizure detection based on the occurrence of a valid seizure detection in a first processed display channel but not detected in a second processed display channel.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2005-10-28	2006-04-29	2006-10-29	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2009-10-28	2010-04-29	2010-10-29	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2013-10-28	2014-04-29	2014-10-29	$7700.00	Window Closed / Lapsed

Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures

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