US5711316A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating movement disorders by brain infusion
Assignee: Medtronic Inc
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Filing: 1996-04-30
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Granted: 1998-01-27
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Expires: 2016-04-30
Abstract
Abstract The present invention is directed to techniques and apparatus for infusing drugs into the brain to treat movement disorders resulting in abnormal motor behavior. The invention employs an implantable pump and a catheter, the catheter having a proximal end coupled to the pump and a discharge portion for placement adjacent a predetermined infusion site in the brain for infusing therapeutic dosages of the one or more drugs into the brain. The pump is operated to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site. A sensor may be used in combination with the implantable pump and catheter, whereby the sensor generates a signal relating to the extent of the abnormal motor behavior. The therapeutic dosage may be regulated in response to the sensor signal so that the dosage is adjusted in response to an increase in the abnormal behavior to decrease the abnormal motor behavior.
Inventors
- 👤 Dennis D. Elsberry
- 👤 Mark T. Rise
- 👤 Scott R. Ward
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:30
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/14244; A61M5/14276; A61M5/168; A61M5/172; A61M5/1723; A61M2202/00; A61M2202/04; A61M2202/0464; A61M2210/00; A61M2210/06; A61M2210/0693
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
106 words
A system for using one or more drugs to treat a movement disorder resulting in abnormal motor behavior, comprising: an implantable pump: a catheter having a proximal end coupled to said pump and a discharge portion adapted to infuse a therapeutic dosage of said one or more drugs into a predetermined infusion site in a brain; an implantable sensor for generating a signal related to the extent of said abnormal motor behavior; and control means responsive to said sensor signal for regulating said therapeutic dosage, whereby the dosage is adjusted in response to an increase in said abnormal motor behavior to decrease said abnormal motor behavior.
Claim 2
Independent Claim
106 words
A system for using one or more drugs to treat a movement disorder resulting in abnormal motor behavior, comprising: an implantable pump: a catheter having a proximal end coupled to said pump and a discharge portion adapted to infuse a therapeutic dosage of said one or more drugs into a predetermined infusion site in a brain; an implantable sensor for generating a signal related to the extent of said abnormal motor behavior; and control means responsive to said sensor signal for regulating said therapeutic dosage, whereby the dosage is adjusted in response to an increase in said abnormal motor behavior to decrease said abnormal motor behavior.
Claim 3
Dependent Claim
14 words
A system, as claimed in claim 1, wherein said sensor comprises a motion detector.
Claim 4
Dependent Claim
26 words
A system, as claimed in claim 1, wherein said sensor comprises means for detecting changes in at least one electrical property of muscle or nerve tissue.
Claim 5
Dependent Claim
14 words
A system, as claimed in claim 1, wherein said control means comprises a microprocessor.
Claim 6
Dependent Claim
15 words
A system, as claimed in claim 1, wherein said control means comprises an electrical filter.
Claim 7
Dependent Claim
15 words
A system, as claimed in claim 1, wherein said movement disorder is a hyperkinetic disorder.
Claim 8
Dependent Claim
15 words
A system, as claimed in claim 1 wherein said movement disorder is a hypokinetic disorder.
Claim 9
Independent Claim
119 words
A system for using one or more drugs to treat a movement disorder resulting in abnormal motor behavior, comprising: an implantable pump: a catheter having a proximal end coupled to said pump and a discharge portion adapted to infuse a therapeutic dosage of said one or more drugs into a predetermined infusion site in a brain; an implantable sensor for generating a signal related to the extent of said abnormal motor behavior, said sensor being adapted to detect changes in at least one biological characteristic; and control means responsive to said sensor signal for regulating said therapeutic dosage, whereby the dosage is adjusted in response to an increase in said abnormal motor behavior to decrease said abnormal motor behavior.
Claim 10
Independent Claim
119 words
A system for using one or more drugs to treat a movement disorder resulting in abnormal motor behavior, comprising: an implantable pump: a catheter having a proximal end coupled to said pump and a discharge portion adapted to infuse a therapeutic dosage of said one or more drugs into a predetermined infusion site in a brain; an implantable sensor for generating a signal related to the extent of said abnormal motor behavior, said sensor being adapted to detect changes in at least one biological characteristic; and control means responsive to said sensor signal for regulating said therapeutic dosage, whereby the dosage is adjusted in response to an increase in said abnormal motor behavior to decrease said abnormal motor behavior.
Claim 11
Dependent Claim
21 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes an electrical property of a muscle.
Claim 12
Dependent Claim
25 words
A system, as claimed in claim 9, wherein said sensor comprises a lead having at least one recording electrode adapted for coupling to said muscle.
Claim 13
Dependent Claim
19 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes force in a muscle.
Claim 14
Dependent Claim
19 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes pressure in a muscle.
Claim 15
Dependent Claim
19 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes force in a joint.
Claim 16
Dependent Claim
19 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes pressure in a joint.
Claim 17
Dependent Claim
21 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes an EEG property of said brain.
Claim 18
Dependent Claim
26 words
A system, as claimed in claim 15, wherein said EEG property of said brain includes motor cortex potentials above motor neurons controlling a specific muscle group.
Claim 19
Dependent Claim
19 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes nerve compound action potentials.
Claim 20
Dependent Claim
22 words
A system, as claimed in claim 17, wherein said nerve compound action potentials include sensory afferent information from muscle or skin receptors.
Claim 21
Dependent Claim
20 words
A system, as claimed in claim 17, wherein said nerve compound action potentials include efferent motor potentials controlling a muscle.
Claim 22
Dependent Claim
20 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes a posture of a patient.
Claim 23
Dependent Claim
34 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes nerve cell or axon activity related to at least one pathway at the cause of said abnormal motor behavior.
Claim 24
Dependent Claim
25 words
A system, as claimed in claim 21, wherein said sensor comprises at least one electrode adapted for insertion into an internal capsule of said brain.
Claim 25
Dependent Claim
29 words
A system, as claimed in claim 8, wherein said at least one biological characteristic includes nerve cell or axon activity that reflects sensations elicited by said abnormal motor behavior.
Claim 26
Dependent Claim
25 words
A system, as claimed in claim 23, wherein said sensor comprises at least one electrode adapted for insertion into an internal capsule of said brain.
Claim 27
Dependent Claim
24 words
A system, as claimed in claim 8, wherein said sensor electronically transduces a concentration of transmitter substance present at a location of said brain.
Claim 28
Independent Claim
117 words
A system for using one or more drugs to treat a movement disorder resulting in abnormal motor behavior, comprising: an implantable pump: a catheter having a proximal end coupled to said pump and a discharge portion adapted to infuse a therapeutic dosage of said one or more drugs into a predetermined infusion site in a brain; an implantable sensor for generating a signal related to the extent of said abnormal motor behavior, said sensor being adapted to detect movement relative to an object; and control means responsive to said sensor signal for regulating said therapeutic dosage, whereby the dosage is adjusted in response to an increase in said abnormal motor behavior to decrease said abnormal motor behavior.
Claim 29
Independent Claim
117 words
A system for using one or more drugs to treat a movement disorder resulting in abnormal motor behavior, comprising: an implantable pump: a catheter having a proximal end coupled to said pump and a discharge portion adapted to infuse a therapeutic dosage of said one or more drugs into a predetermined infusion site in a brain; an implantable sensor for generating a signal related to the extent of said abnormal motor behavior, said sensor being adapted to detect movement relative to an object; and control means responsive to said sensor signal for regulating said therapeutic dosage, whereby the dosage is adjusted in response to an increase in said abnormal motor behavior to decrease said abnormal motor behavior.
Claim 30
Dependent Claim
13 words
A system, as claimed in claim 26, wherein said object is a magnet.
Claim 31
Dependent Claim
12 words
A system, as claimed in claim 27, wherein said magnet is implantable.
Claim 32
Dependent Claim
12 words
A system, as claimed in claim 26, wherein said object is implantable.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-26 | 2001-07-28 | 2002-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-26 | 2005-07-28 | 2006-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-26 | 2009-07-28 | 2010-01-27 | $7700.00 | Window Closed / Lapsed |