US5540730A
Expired / Lapsed
US
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Treatment of motility disorders by nerve stimulation
Assignee: Livanova USA Inc
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Filing: 1995-06-06
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Granted: 1996-07-30
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Expires: 2015-06-06
Abstract
Abstract Apparatus for treating patients with motility disorders applies a modulating signal to the patient's vagus nerve to stimulate or inhibit neural impulses and produce excitatory or inhibitory neurotransmitter release by the vagus nerve according to the specific nature of the motility disorder. The apparatus includes a neurostimulator which can be activated to generate an electrical output signal. The neurostimulator is responsive to the sensing of a selected event having occurred which is indicative of the need for treatment of the motility disorder, and includes an activation element which responds to sensing of that event to activate the neurostimulator, and a lead with an electrode array to apply the electrical output signal as the modulating signal to the patient's vagus nerve. Certain parameters of the output signal are programmable, and the neurostimulator can be calibrated according to the specific patient and the specific motility disorder being treated. One form of sensor detects the impedance of a selected part of the gastrointestinal system to detect the presence of excessive contractions in that part as an indication of hypermotility whether or not food has been consumed by the patient within a preset interval of time, and inadequate contractions in that part as an indication of hypomotility if food was consumed by the patient within a preset interval of time.
Inventors
- 👤 Reese S. Terry, Jr.
- 👤 Ross G. Baker, Jr.
- 👤 Andre Marquette
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:02
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/36007; A61N1/326
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
86 words
A method of treating patients suffering from motility disorders, comprising the steps of: sensing a prescribed event indicative of an imminent need for treatment of a specific motility disorder of interest, and responding to the sensed occurrence of the prescribed event by applying a stimulating electrical signal having predetermined electrical parameters to the patient's vagus nerve to modulate the electrical activity of the vagus nerve in a manner to produce a reaction in the patient's gastrointestinal tract by which to alleviate the motility disorder of interest.
Claim 2
Independent Claim
86 words
A method of treating patients suffering from motility disorders, comprising the steps of: sensing a prescribed event indicative of an imminent need for treatment of a specific motility disorder of interest, and responding to the sensed occurrence of the prescribed event by applying a stimulating electrical signal having predetermined electrical parameters to the patient's vagus nerve to modulate the electrical activity of the vagus nerve in a manner to produce a reaction in the patient's gastrointestinal tract by which to alleviate the motility disorder of interest.
Claim 3
Dependent Claim
51 words
The method of claim 1, wherein: the prescribed event is inadequate contractions of at least a predesignated portion of the patient's gastrointestinal tract compared with a range of contractions observed in human digestive systems deemed to be normal, within a predetermined interval of time following consumption of food by the patient.
Claim 4
Dependent Claim
17 words
The method of claim 2, wherein: the predesignated portion of the patient's gastrointestinal tract is the stomach.
Claim 5
Dependent Claim
70 words
The method of claim 1, wherein: the prescribed event is onset of excessively rapid contractions of at least a predesignated portion of the patient's gastrointestinal tract compared with speed of contractions observed in human digestive systems deemed to be normal, within one of (i) a predetermined interval of time following consumption of food by the patient, and (ii) a predetermined interval of time without consumption of food by the patient.
Claim 6
Dependent Claim
17 words
The method of claim 4, wherein: the predesignated portion of the patient's gastrointestinal tract is the stomach.
Claim 7
Dependent Claim
49 words
The method of claim 1, wherein: the prescribed event is sensing by the patient of symptoms of the motility disorder of interest, and the response is the patient's own recognition of the need for treatment by voluntarily initiating the application of said stimulating electrical signal to the vagus nerve.
Claim 8
Dependent Claim
34 words
The method of claim 1, wherein: said stimulating signal is applied to the patient's vagus nerve by application to a nerve electrode implanted on the vagus nerve in the vicinity of the patient's stomach.
Claim 9
Dependent Claim
122 words
Apparatus for treating patients with motility disorders by application of a modulating signal to the patient's vagus nerve to stimulate or inhibit neural impulses and produce excitatory or inhibitory neurotransmitter release by the nerve according to the specific nature of the motility disorder, comprising: neurostimulator means for generating an electrical output signal in response to activation thereof, said neurostimulator means including sensing means for detecting the occurrence of a selected event indicative of the need for imminent treatment of the motility disorder, and including activating means responsive to the detection for activating said neurostimulator means, and lead/electrode means responsive to generation of the electrical output signal by said neurostimulator means for application thereof as said modulating signal to the patient's vagus nerve.
Claim 10
Dependent Claim
122 words
Apparatus for treating patients with motility disorders by application of a modulating signal to the patient's vagus nerve to stimulate or inhibit neural impulses and produce excitatory or inhibitory neurotransmitter release by the nerve according to the specific nature of the motility disorder, comprising: neurostimulator means for generating an electrical output signal in response to activation thereof, said neurostimulator means including sensing means for detecting the occurrence of a selected event indicative of the need for imminent treatment of the motility disorder, and including activating means responsive to the detection for activating said neurostimulator means, and lead/electrode means responsive to generation of the electrical output signal by said neurostimulator means for application thereof as said modulating signal to the patient's vagus nerve.
Claim 11
Dependent Claim
41 words
The apparatus of claim 8, wherein: said neurostimulator means further includes: programming means for selectively programming the parameters of the electrical output signal of said neurostimulator means according to the nature of the motility disorder being treated, within respective predetermined ranges.
Claim 12
Dependent Claim
29 words
The apparatus of claim 8, wherein: said neurostimulator memos further includes: means for calibrating the neurostimulator means according to the specific patient and the specific motility disorder being treated.
Claim 13
Dependent Claim
56 words
The apparatus of claim 8, wherein: the motility disorder being treated is hypomotility, and said sensing means comprises impedance detecting means responsive to an absence of contractions of specified magnitude in the gastrointestinal system of the patient within a predetermined interval of time after consumption of food by the patient as the event to be detected.
Claim 14
Dependent Claim
60 words
The apparatus of claim 8, wherein: the motility disorder being treated is hypermotility, and said sensing means comprises impedance detecting means responsive to contractions in the gastrointestinal system of the patient despite an absence of consumption of food by the patient within a predetermined interval of time prior to the onset of said contractions as the event to be detected.
Claim 15
Dependent Claim
28 words
The apparatus of claim 8, wherein: said sensing means comprises means for detecting voluntary triggering of said activating means by the patient as the event to be detected.
Claim 16
Dependent Claim
32 words
The apparatus of claim 8, wherein: said lead/electrode means includes nerve electrode means and means for securing said nerve electrode means to the patient's vagus nerve in the vicinity of the stomach.
Claim 17
Dependent Claim
20 words
The apparatus of claim 8, wherein: said neurostimulator means is arranged and adapted to be implanted in the patient's body.
Claim 18
Independent Claim
102 words
A method of treating a patient suffering from a motility disorder in which a medical therapeutic device is implanted in the patient's body, comprising the device-implemented steps of: detecting a response of the patient's gastrointestinal (GI) tract to consumption of food by the patient which is abnormal relative to predetermined normal human digestive processes and is indicative of a need for treatment to alleviate a motility disorder of interest, and after detecting the abnormal response, applying to the patient's vagus nerve an electrical stimulus configured to modulate the electrical activity of the nerve such that the motility disorder of interest is alleviated.
Claim 19
Independent Claim
102 words
A method of treating a patient suffering from a motility disorder in which a medical therapeutic device is implanted in the patient's body, comprising the device-implemented steps of: detecting a response of the patient's gastrointestinal (GI) tract to consumption of food by the patient which is abnormal relative to predetermined normal human digestive processes and is indicative of a need for treatment to alleviate a motility disorder of interest, and after detecting the abnormal response, applying to the patient's vagus nerve an electrical stimulus configured to modulate the electrical activity of the nerve such that the motility disorder of interest is alleviated.
Claim 20
Dependent Claim
29 words
The method of claim 16, further including the step of delaying the detecting step until the expiration of a predetermined interval of time from initial consumption of the food.
Claim 21
Dependent Claim
48 words
The method of claim 16, wherein: the abnormal response to be detected is preselected to consist of abnormally slow contractions of the patient's GI tract where the patient is suffering from hypomotility, and abnormally rapid contractions of the patient's GI tract where the patient is suffering from hypermotility.
Claim 22
Dependent Claim
26 words
The method of claim 18, wherein: the detecting step is performed by sensing electrical phenomena indicative of presence or absence of contractions of the patient's stomach.
Claim 23
Dependent Claim
27 words
The method of claim 18, wherein: the detecting step is performed by sensing electrical phenomena indicative of presence or absence of contractions of the patient's large intestine.
Claim 24
Dependent Claim
29 words
The method of claim 16, wherein: the electrical stimulus is configured as a pulsed signal by programming parameters of the signal including on-time, off-time, frequency, pulse width, and current.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-30 | 2000-01-29 | 2000-07-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-30 | 2004-01-29 | 2004-07-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-30 | 2008-01-29 | 2008-07-30 | $7700.00 | Window Closed / Lapsed |