Method of inducing bone growth using TGF-β

Abstract

Abstract A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF- beta in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF- beta and a source of osteogenic cells in a pharmaceutically acceptable carrier.

Inventors

• 👤 Arthur J. Ammann
• 👤 Christopher G. Rudman

Bibliographic Details