Patent US2333554A successfully refreshed from Google Patents.
Patent US6468660B2 successfully refreshed from Google Patents.
US6468660B2
Expired / Lapsed
US
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Biocompatible adhesives
Assignee: St Jude Medical LLC
•
Filing: 2000-12-29
•
Granted: 2002-10-22
•
Expires: 2020-12-29
Abstract
Abstract Novel adhesive compositions are described that include an epoxyamine and, preferably, a curing agent. The adhesive composition can be used in surgical settings such as implanting bioprostheses and/or in manufacturing of bioprostheses. Biocompatible substrates can be adhered together by an adhesive bond formed by curing of the epoxyamine adhesive composition.
Inventors
- 👤 Matthew F. Ogle
- 👤 Andrea L. McConico
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:34
CPC Classifications
C; C09; C09J; C09J163/00; A; A61; A61L; A61L24/00; A61L24/04; A61L24/046; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31511; Y10T428/31515
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
36 words
An adhesive composition comprising an epoxyamine and a curing agent, wherein the epoxyamine is at a concentration of between about 25 percent by weight and about 90 percent by weight, wherein the adhesive composition is biocompatible.
Claim 2
Dependent Claim
36 words
An adhesive composition comprising an epoxyamine and a curing agent, wherein the epoxyamine is at a concentration of between about 25 percent by weight and about 90 percent by weight, wherein the adhesive composition is biocompatible.
Claim 3
Dependent Claim
28 words
The adhesive composition of claim 1 wherein an adhesive bond is formed when the adhesive composition is associated with a first substrate and joined to a second substrate.
Claim 4
Dependent Claim
12 words
The adhesive composition of claim 1 wherein the epoxyamine is triglycidyl amine.
Claim 5
Dependent Claim
30 words
The adhesive composition of claim 1 wherein the curing agent comprises a functional group selected from the group consisting of sulfur-containing functional groups, nitrogen-containing functional groups and oxygen-containing functional groups.
Claim 6
Dependent Claim
27 words
The adhesive composition of claim 1 wherein the curing agent comprises a functional group selected from the group consisting of a thiol, an alcohol and an amine.
Claim 7
Dependent Claim
14 words
The adhesive composition of claim 1 wherein the adhesive composition further comprises a flexibilizer.
Claim 8
Dependent Claim
22 words
The adhesive composition of claim 6 wherein the flexibilizer is selected from the group consisting of collagen, albumin, glycosaminoglycans and combinations thereof.
Claim 9
Dependent Claim
18 words
The adhesive composition of claim 2 wherein the adhesive bond is formed after at least about one minute.
Claim 10
Dependent Claim
27 words
The adhesive composition of claim 1 wherein the curing agent is between about 1 percent by weight and about 20 percent by weight of the adhesive composition.
Claim 11
Dependent Claim
26 words
The adhesive composition of claim 6 wherein the flexibilizer is between about 1 percent by weight and about 40 percent by weight of the adhesive composition.
Claim 12
Dependent Claim
12 words
The adhesive composition of claim 1 further comprising a biological response modifier.
Claim 13
Dependent Claim
15 words
The adhesive composition of claim 11 wherein the biological response modifier comprises transforming growth factor-beta.
Claim 14
Dependent Claim
18 words
A medical adhesive comprising an adhesive composition and transforming growth factor-beta wherein the adhesive composition comprises an epoxyamine.
Claim 15
Dependent Claim
18 words
A medical adhesive comprising an adhesive composition and transforming growth factor-beta wherein the adhesive composition comprises an epoxyamine.
Claim 16
Dependent Claim
18 words
A medical device having two substrates secured with a cured form of the adhesive of claim 13 .
Claim 17
Dependent Claim
14 words
The medical device of claim 14 wherein the medical device is an implantable prosthesis.
Claim 18
Dependent Claim
17 words
The adhesive composition of claim 1 , wherein the epoxyamine comprises a plurality of different epoxyamine compounds.
Claim 19
Dependent Claim
15 words
The adhesive composition of claim 1 , wherein the composition further comprises a resorbable composition.
Claim 20
Dependent Claim
15 words
The adhesive composition of claim 1 , wherein the adhesive composition further comprises a solvent.
Claim 21
Dependent Claim
12 words
The adhesive composition of claim 18 , wherein the solvent comprises water.
Claim 22
Dependent Claim
14 words
The adhesive composition of claim 19 , wherein the solvent further comprises a buffer.
Claim 23
Dependent Claim
14 words
The adhesive composition of claim 19 , wherein the adhesive composition further comprises salt.
Claim 24
Dependent Claim
16 words
The adhesive composition of claim 1 , wherein the adhesive composition further comprises a softening agent.
Claim 25
Dependent Claim
16 words
The adhesive composition of claim 11 , wherein the biological response modifier comprises an antimicrobial agent.
Claim 26
Dependent Claim
16 words
The adhesive composition of claim 11 , wherein the biological response modifier comprises an anticalcification agent.
Claim 27
Dependent Claim
18 words
The adhesive composition of claim 2 , wherein the fist substrate and the second substrate are native tissue.
Claim 28
Dependent Claim
31 words
A prosthesis, wherein the prosthesis comprises a first substrate and a second substrate, wherein the first substrate and the second substrate are adhered by the adhesive composition of claim 1 .
Claim 29
Dependent Claim
16 words
The medical adhesive of claim 13 , wherein the adhesive composition further comprises a curing agent.
Claim 30
Dependent Claim
28 words
The medical adhesive of claim 27 , wherein the curing agent is between about 1 percent by weight and about 20 percent by weight of the adhesive composition.
Claim 31
Dependent Claim
12 words
The medical adhesive of claim 13 , wherein the epoxyamine comprises triglycidylamine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-10-21 | 2006-04-22 | 2006-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-10-21 | 2010-04-22 | 2010-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-10-21 | 2014-04-22 | 2014-10-22 | $7700.00 | Window Closed / Lapsed |