EP0747066A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Biocompatible adhesive compositions
Assignee: Angiotech Biomaterials Corp
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Filing: 1996-05-29
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Granted: —
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Expires: 2016-05-29
Abstract
Abstract Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.
Inventors
- 👤 Wonza M. Rhee
- 👤 Prema R. Rao
- 👤 George H. Chu
- 👤 Frank A. Delustro
- 👤 Carol F.H. Harner
- 👤 Naomi Sakai
- 👤 Jacqueline A. Schroeder
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-24 04:38
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/04; A61L31/043; A61L31/044; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/61; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/50; A61L27/54; A61L31/041; A61L31/08; A61L31/10; A61L31/12; A61L31/125; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495; C07K14/78; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0069; C08B37/0072; C08H; C08H1/00; C08H1/06; C08L; C08L89/00; C08L89/04; C08L89/06; C09; C09J; C09J189/00; C09J189/04; C09J189/06; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K38/00; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414; A61L2430/00; A61L2430/16; C08L2666/00; C08L2666/02; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84; Y10S602/00; Y10S602/904
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
51 words
A composition comprising fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer, wherein the fiber disassembly agent is present in an amount sufficient to render the collagen substantially nonfibrillar at pH 7, and wherein the collagen and synthetic polymer covalently bind to form a collagen-synthetic polymer conjugate.
Claim 2
Dependent Claim
29 words
The composition of claim 1, wherein the fiber disassembly agent is selected from the group consisting of: a biocompatible alcohol, an amino acid, an inorganic salt, and a carbohydrate.
Claim 3
Dependent Claim
24 words
The composition of claim 2, wherein the fiber disassembly agent is a biocompatible alcohol selected from the group consisting of glycerol and propylene glycol.
Claim 4
Dependent Claim
49 words
A composition comprising fibrillar collagen, a biocompatible alcohol, and a multifunctionally activated synthetic hydrophilic polymer, wherein the biocompatible alcohol is present in an amount sufficient to render the collagen substantially non-fibrillar at pH 7, and wherein the collagen and synthetic polymer covalently bind to form a collagen-synthetic polymer conjugate.
Claim 5
Dependent Claim
20 words
The composition of claim 4, wherein the biocompatible alcohol is selected from the group consisting of glycerol and propylene glycol.
Claim 6
Dependent Claim
22 words
The composition of any one of the preceding claims, wherein the multifunctionally activated synthetic hydrophilic polymer is a multifunctionally activated polyethylene glycol.
Claim 7
Dependent Claim
25 words
The composition of claim 6, wherein the multifunctionally activated polyethylene glycol is selected from the group consisting of difunctionally activated SG-PEG and difunctionally activated SE-PEG.
Claim 8
Independent Claim
88 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, comprising the steps of: providing collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the collagen and synthetic polymer to initiate crosslinking between the collagen and the synthetic polymer; applying the mixture of collagen and synthetic polymer to a first surface before substantial crosslinking has occurred between the collagen and the synthetic polymer; and contacting the first surface with a second surface to effect adhesion between the first surface and the second surface.
Claim 9
Independent Claim
93 words
A method for preventing the formation of adhesions following surgery, comprising the steps of: providing collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the collagen and the synthetic polymer to initiate crosslinking between the collagen and the synthetic polymer; applying the mixture of collagen and synthetic polymer to tissue comprising, surrounding, or adjacent to a surgical site before substantial crosslinking has occurred between the collagen and synthetic polymer; allowing the collagen and synthetic polymer to continue crosslinking in situ until equilibrium crosslinking has been achieved; and effecting closure of the surgical site.
Claim 10
Dependent Claim
13 words
The method of claim 8 or 9, wherein the collagen is nonfibrillar collagen.
Claim 11
Independent Claim
92 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, comprising the steps of: providing nonfibrillar collagen and a multifunctionally activated synthetic hydrophilic polymer; mixing the nonfibrillar collagen and synthetic polymer to initiate crosslinking between the nonfibrillar collagen and the synthetic polymer; applying the mixture of nonfibrillar collagen and synthetic polymer to a first surface before substantial crosslinking has occurred between the collagen and the synthetic polymer; and contacting the first surface with a second surface to effect adhesion between the first surface and the second surface.
Claim 12
Independent Claim
84 words
A method for effecting the nonsurgical attachment of a first surface to a second surface, wherein the both of the first surface and the second surface contain nucleophilic groups, said method comprising the steps of: applying a multifunctionally activated synthetic hydrophilic polymer to a first surface; and contacting the first surface with a second surface, whereby the synthetic polymer will covalently bind to nucleophilic groups on the first surface and the second surface to effect adhesion between the first surface and the second surface.
Claim 13
Independent Claim
23 words
The method of any one of claims 8 to 12, wherein one of the first and second surfaces is a native tissue surface.
Claim 14
Independent Claim
46 words
The method of any one of claims 8 to 12, wherein one of the first and second surfaces is a native tissue surface and the other of the first and second surfaces is selected from a non-native tissue surface and a surface of a synthetic implant.
Claim 15
Independent Claim
21 words
The method of any one of claims 8 to 12, wherein both the first and second surfaces are native tissue surfaces.
Claim 16
Dependent Claim
35 words
The method of claim 10 or 11, wherein the nonfibrillar collagen was prepared by mixing fibrillar collagen with a fiber disassembly agent in an amount sufficient to render the collagen substantially nonfibrillar at pH 7.
Claim 17
Dependent Claim
29 words
The method of claim 16, wherein the fiber disassembly agent is selected from the group consisting of: a biocompatible alcohol, an amino acid, an inorganic salt, and a carbohydrate.
Claim 18
Dependent Claim
24 words
The method of claim 17, wherein the fiber disassembly agent is a biocompatible alcohol selected from the group consisting of glycerol and propylene glycol.
Claim 19
Dependent Claim
16 words
The method of claim 10 or 11, wherein the nonfibrillar collagen is a chemically modified collagen.
Claim 20
Dependent Claim
13 words
The method of claim 19, wherein the chemically modified collagen is methylated collagen.
Claim 21
Dependent Claim
28 words
The method of claim 10 or 11, wherein the nonfibrillar collagen is selected from the group consisting of: type IV collagen, type VI collagen, and type VII collagen.
Claim 22
Dependent Claim
13 words
The method of claim 8 or 9, wherein the collagen is fibrillar collagen.
Claim 23
Dependent Claim
19 words
The method of claim 8 or 9, wherein the collagen comprises a mixture of nonfibrillar collagen and fibrillar collagen.
Claim 24
Dependent Claim
20 words
The method of claim 22, wherein the collagen comprises a mixture of particulate crosslinked fibrillar collagen and noncrosslinked fibrillar collagen.
Claim 25
Dependent Claim
14 words
The method of claim 24, wherein the particulate crosslinked fibrillar collagen comprises glutaraldehyde-crosslinked collagen.
Claim 26
Dependent Claim
39 words
The method of claim 24, wherein the particulate crosslinked fibrillar collagen comprises between about 25 % to about 95 % and the noncrosslinked fibrillar collagen comprises between about 5 % to about 75 % by weight of the composition.
Claim 27
Dependent Claim
11 words
The method of claim 8, wherein the collagen is denatured collagen.
Claim 28
Independent Claim
23 words
The method of any one of claims 8 to 27, wherein the multifunctionally activated synthetic hydrophilic polymer is a multifunctionally activated polyethylene glycol.
Claim 29
Dependent Claim
25 words
The method of claim 28, wherein the multifunctionally activated polyethylene glycol is selected from the group consisting of difunctionally activated SG-PEG and difunctionally activated SE-PEG.
References Cited (Backward Citations)
No citation records indexed.
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