Patent US6413245B1 successfully refreshed from Google Patents.
US6413245B1
Expired / Lapsed
US
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Sub-tenon drug delivery
Assignee: Novartis AG
•
Filing: 2000-10-04
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Granted: 2002-07-02
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Expires: 2020-10-04
Abstract
Abstract Disclosed is a method and apparatus for delivering a drug formulation to a human eye. The method includes the steps of inserting the apparatus below the Tenon's capsule and above the sclera at a point posterior to the limbus of the eye and injecting the drug formulation to form a drug depot on an outer surface of the sclera. The apparatus includes a cannula having a distal portion, a proximal portion, and a bend separating the distal portion and the proximal portion. The distal portion has a radius of curvature substantially equal to a radius of curvature of the globe of the eye. A tangent of the distal portion at the bend is disposed at an angle no more than about 56 degrees with respect to the proximal portion.
Inventors
- 👤 Yoseph Yaacobi
- 👤 Abbot F. Clark
- 👤 David C. Dahlin
- 👤 Craig B. Struble
- 👤 David Allen Marsh
- 👤 Billie M. York
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:07
CPC Classifications
A; A61; A61F; A61F9/00; A61F9/0008; A61F9/0017; A61F2250/00; A61F2250/0058; A61F2250/0067
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
67 words
A cannula, comprising: a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of a human eye; a proximal portion; and a bend separating said distal portion and said proximal portion, wherein a tangent of said distal portion at said bend is disposed at an angle of no more than about 56 degrees with respect to said proximal portion.
Claim 2
Dependent Claim
67 words
A cannula, comprising: a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of a human eye; a proximal portion; and a bend separating said distal portion and said proximal portion, wherein a tangent of said distal portion at said bend is disposed at an angle of no more than about 56 degrees with respect to said proximal portion.
Claim 3
Dependent Claim
21 words
The cannula of claim 1 wherein said distal portion comprises an arc length of about 15 mm to about 18 mm.
Claim 4
Dependent Claim
34 words
The cannula of claim 1 further comprising: a hub coupled to said proximal portion for removably coupling to a syringe; and a hollow bore disposed axially within said distal portion and said proximal portion.
Claim 5
Dependent Claim
23 words
The cannula of claim 3 wherein said distal portion has a plurality of orifices, each of said orifices communicating with said hollow bore.
Claim 6
Dependent Claim
35 words
The cannula of claim 3 wherein said bend is adopted to prevent said syringe from interfering with a patient's face, bridge of the nose, and eyebrows when said distal portion is inserted into said eye.
Claim 7
Dependent Claim
23 words
The cannula of claim 1 wherein said distal portion comprises an interior side and a tip having an orifice on said interior side.
Claim 8
Dependent Claim
27 words
The cannula of claim 1 wherein said distal portion has a radius of curvature substantially equal to a radius of curvature of a sclera of said eye.
Claim 9
Dependent Claim
22 words
The cannula of claim 1 wherein said radius of curvature of said distal portion is about 11.5 mm to about 14 mm.
Claim 10
Dependent Claim
13 words
The cannula of claim 1 wherein said distal portion is made of plastic.
Claim 11
Dependent Claim
44 words
The cannula of claim 1 wherein said distal portion comprises a tip and an orifice proximate said tip, and wherein a part of said distal portion proximate said tip is made of plastic, and a remainder of said distal portion is made from metal.
Claim 12
Dependent Claim
12 words
The cannula of claim 1 wherein said angle is about 56 degrees.
Claim 13
Dependent Claim
16 words
The cannula of claim 1 wherein said distal portion comprises a tip having an olive shape.
Claim 14
Dependent Claim
22 words
The cannula of claim 1 wherein said distal portion comprises: a tip; and a fiber optic light source disposed at said tip.
Claim 15
Dependent Claim
40 words
The cannula of claim 1 wherein said distal portion, said proximal portion, and said bend comprise a first lumen, and further comprising: a second lumen having a geometry substantially similar to said first lumen and disposed adjacent said first lumen.
Claim 16
Dependent Claim
16 words
The cannula of claim 14 wherein said first lumen and second lumen are not in communication.
Claim 17
Dependent Claim
24 words
The cannula of claim 14 further comprising a tip, and wherein said first lumen and said second lumen are in communication proximate said tip.
Claim 18
Dependent Claim
20 words
The cannula of claim 1 wherein said distal portion and said proximal portion are formed of 19 gauge needle stock.
Claim 19
Independent Claim
125 words
A method of delivering a drug to a human eye, comprising the steps of: inserting a cannula below a Tenon's capsule and above a sclera of said human eye at a point posterior to a limbus of said eye, said cannula comprising: a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of said human eye; a proximal portion; and a bend separating said distal portion and said proximal portion, wherein a tangent of said distal portion at said bend is disposed at an angle of no more than about 56 degrees with respect to said proximal portion; injecting a drug formulation through said cannula to form a drug depot on an outer surface of said sclera.
Claim 20
Independent Claim
125 words
A method of delivering a drug to a human eye, comprising the steps of: inserting a cannula below a Tenon's capsule and above a sclera of said human eye at a point posterior to a limbus of said eye, said cannula comprising: a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of said human eye; a proximal portion; and a bend separating said distal portion and said proximal portion, wherein a tangent of said distal portion at said bend is disposed at an angle of no more than about 56 degrees with respect to said proximal portion; injecting a drug formulation through said cannula to form a drug depot on an outer surface of said sclera.
Claim 21
Dependent Claim
30 words
The method of claim 18 wherein said distal portion of said cannula comprises a tip, and further comprising the step of disposing said tip proximate a macula of said eye.
Claim 22
Dependent Claim
12 words
The method of claim 18 wherein said drug formulation comprises a suspension.
Claim 23
Dependent Claim
13 words
The method of claim 20 wherein said suspension comp rises a bioerodable polymer.
Claim 24
Dependent Claim
12 words
The method of claim 20 wherein said suspension comprises a non-bioerodable polymer.
Claim 25
Dependent Claim
12 words
The method of claim 18 wherein said drug formulation comprises an emulsion.
Claim 26
Dependent Claim
12 words
The method of claim 18 wherein said drug formulation comprises an ointment.
Claim 27
Dependent Claim
14 words
The method of claim 18 wherein said drug formulation forming solution comprises a gel.
Claim 28
Dependent Claim
27 words
The method of claim 18 wherein said distal portion has a radius of curvature substantially equal to a radius of curvature of a sclera of said eye.
Claim 29
Dependent Claim
21 words
The method of claim 18 wherein said inserting step comprises inserting said cannula into a superior temporal quadrant of said eye.
Claim 30
Dependent Claim
21 words
The method of claim 18 wherein said inserting step comprises inserting said cannula into an inferior temporal quadrant of said eye.
Claim 31
Dependent Claim
23 words
The method of claim 18 wherein said drug formulation comprises a pharmaceutically active agent selected from the group consisting of 4,9(11)-Pregnadien-17α,21-diol-3,20-dione and 4,9(11)-Pregnadien-17α,21-diol-3,20-dione-21-acetate.
Claim 32
Dependent Claim
11 words
The method of claim 18 wherein said drug formulation comprises eliprodil.
Claim 33
Dependent Claim
11 words
The method of claim 18 wherein said drug formulation comprises nepafenac.
Claim 34
Independent Claim
100 words
A method of delivering a drug to a human eye, comprising the steps of: inserting a cannula below a Tenon's capsule and above a sclera of said human eye at a point posterior to a limbus of said eye, said cannula having a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of said eye; and injecting a drug formulation through said cannula to form a drug depot on an outer surface of said sclera, said drug formulation comprising a pharmaceutically active agent selected from the group consisting of 4,9(11)-Pregnadien-17α,21-diol-3,20-dione and 4,9(11)-Pregnadien-17α,21-diol-3,20-dione-21-acetate.
Claim 35
Independent Claim
100 words
A method of delivering a drug to a human eye, comprising the steps of: inserting a cannula below a Tenon's capsule and above a sclera of said human eye at a point posterior to a limbus of said eye, said cannula having a distal portion having a radius of curvature substantially equal to a radius of curvature of a globe of said eye; and injecting a drug formulation through said cannula to form a drug depot on an outer surface of said sclera, said drug formulation comprising a pharmaceutically active agent selected from the group consisting of 4,9(11)-Pregnadien-17α,21-diol-3,20-dione and 4,9(11)-Pregnadien-17α,21-diol-3,20-dione-21-acetate.
Claim 36
Dependent Claim
28 words
The method of claim 32 wherein said injecting step comprises forming said drug depot on said outer surface of said sclera generally above a macula of said eye.
Claim 37
Dependent Claim
20 words
The method of claim 32 further comprising disposing a tip of said distal portion proximate said macula of said eye.
Claim 38
Dependent Claim
59 words
A cannula, comprising: a hub for removably coupling to a syringe; a proximal portion; and a distal portion having a tip, an orifice proximate said tip, and a radius of curvature substantially equal to a radius of curvature of a globe of a human eye, wherein a part of said distal portion proximate said tip is made of plastic.
Claim 39
Dependent Claim
59 words
A cannula, comprising: a hub for removably coupling to a syringe; a proximal portion; and a distal portion having a tip, an orifice proximate said tip, and a radius of curvature substantially equal to a radius of curvature of a globe of a human eye, wherein a part of said distal portion proximate said tip is made of plastic.
Claim 40
Dependent Claim
16 words
The cannula of claim 35 wherein a remainder of said distal portion is formed of metal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2005-07-01 | 2005-12-31 | 2006-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2009-07-01 | 2009-12-31 | 2010-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2013-07-01 | 2013-12-31 | 2014-07-02 | $7700.00 | Window Closed / Lapsed |