EP0904787A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Scleral plug containing proteinaceous medicine
Assignee: Santen Pharmaceutical Co Ltd
•
Filing: 1997-03-19
•
Granted: —
•
Expires: 2017-03-19
Abstract
Abstract The present invention provides a technique enabling a drug of protein derivatives such as an interferon-β to be effectively applied to intraocular diseases such as diseases of a vitreous body, retina, and the like. Namely, the present invention provides a composition comprising a drug of protein derivatives adsorbed on a surface of fine particles of a lactic acid copolymer, and also a scleral plug formed from the composition. The average diameter of the fine particles is less than 1,000 nanometers, preferably within a range of 50 to 500 nanometers. The drug of protein derivatives is, for example, an interferon, particularly an interferon-β. The lactic acid copolymer preferably comprises lactic acid units and glycolic acid units.
Inventors
- 👤 Yuichiro Ogura
- 👤 Noriyuki Kunou
- 👤 Atsutoshi Ota
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-28 13:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5146; A61K9/5153; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/215; A61K9/0012; A61K9/0048; A61K9/0051
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
22 words
A composition characterized by comprising a drug of
protein derivatives adsorbed on a surface of fine particles of
a lactic acid copolymer.
Claim 2
Dependent Claim
19 words
The composition according to claim 1, wherein an average
diameter of the fine particles is less than 1,000 nanometers.
Claim 3
Dependent Claim
23 words
The composition according to claim 1, wherein an average
diameter of the fine particles is within a range of 50 to 500
nanometers.
Claim 4
Dependent Claim
15 words
The composition according to claim 1, wherein the drug
of protein derivatives is an interferon.
Claim 5
Dependent Claim
12 words
The composition according to claim 4, wherein the
interferon is an interferon-β.
Claim 6
Dependent Claim
19 words
The composition according to claim 1, wherein the lactic
acid copolymer comprises lactic acid units and glycolic acid
units.
Claim 7
Dependent Claim
37 words
A composition characterized by comprising an interferon-β
adsorbed on fine particles of a lactic acid copolymer that
comprises lactic acid units and glycolic acid units, the fine
particles having an average diameter of less than 1,000
nanometers.
Claim 8
Dependent Claim
27 words
A scleral plug formed from a composition characterized
by comprising a drug of protein derivatives adsorbed on a
surface of fine particles of a lactic acid copolymer.
Claim 9
Dependent Claim
20 words
The scleral plug according to claim 8, wherein an average
diameter of the fine particles is less than 1,000 nanometers.
Claim 10
Dependent Claim
24 words
The scleral plug according to claim 8, wherein an average
diameter of the fine particles is within a range of 50 to 500
nanometers.
Claim 11
Dependent Claim
16 words
The scleral plug according to claim 8, wherein the drug
of protein derivatives is an interferon.
Claim 12
Dependent Claim
13 words
The scleral plug according to claim 11, wherein the
interferon is an interferon-β.
Claim 13
Dependent Claim
20 words
The scleral plug according to claim 8, wherein the lactic
acid copolymer comprises lactic acid units and glycolic acid
units.
Claim 14
Dependent Claim
42 words
A scleral plug formed from a composition characterized
by comprising an interferon-β adsorbed on fine particles of
a lactic acid copolymer that comprises lactic acid units and
glycolic acid units, the fine particles having an average
diameter of less than 1,000 nanometers.
Claim 15
Dependent Claim
26 words
The scleral plug according to claim 8, wherein a weight
average molecular weight of the lactic acid copolymer is within
a range of 10,000 to 1,000,000.
Claim 16
Dependent Claim
26 words
The scleral plug according to claim 8, wherein a weight
average molecular weight of the lactic acid copolymer is within
a range of 20,000 to 200,000.
Claim 17
Dependent Claim
35 words
The scleral plug according to any one of claims 8 to 16,
wherein a compositional molar ratio of the lactic acid units
to the glycolic acid units is within a range of 50/50 to 100/0.
Claim 18
Dependent Claim
35 words
The scleral plug according to any one of claims 8 to 16,
wherein a compositional molar ratio of the lactic acid units
to the glycolic acid units is within a range of 50/50 to 80/20.
Claim 19
Dependent Claim
35 words
The scleral plug according to any one of claims 8 to 16,
wherein a compositional molar ratio of the lactic acid units
to the glycolic acid units is within a range of 70/30 to 80/20.
Claim 20
Dependent Claim
34 words
A scleral plug formed from a composition comprising a drug
of protein derivatives adsorbed on a surface of fine particles
of a lactic acid copolymer, the drug being gradually released
into a vitreous body.
Claim 21
Dependent Claim
48 words
A scleral plug for treatment or prevention of an
intraocular diseases, the scleral plug being formed from a
composition characterized by comprising a drug of protein
derivatives adsorbed on a surface of fine particles of a lactic
acid copolymer, the drug being gradually released into a
vitreous body.
Claim 22
Dependent Claim
15 words
The scleral plug according to claim 21, wherein the
intraocular diseases is a retinal disease.
Claim 23
Dependent Claim
21 words
The scleral plug according to claim 22, wherein the
retinal disease is diabetic retinopathy, macular degeneration,
or retinal central vein obstruction.
Claim 24
Dependent Claim
68 words
A scleral plug formed from a composition characterized
by comprising an interferon-β adsorbed on a surface of fine
particles of a lactic acid copolymer, the lactic acid copolymer
having a compositional molar ratio of lactic acid units to
glycolic acid units within a range of 50/50 to 100/0 and having
a weight average molecular weight of 10,000 to 1,000,000, the
interferon-β being gradually released into a vitreous body.
Claim 25
Dependent Claim
70 words
A scleral plug formed from a composition characterized
by being formed comprising an interferon-β adsorbed on a
surface of fine particles of a lactic acid copolymer, the lactic
acid copolymer having a compositional molar ratio of lactic acid
units to glycolic acid units within a range of 70/30 to 80/20
and having a weight average molecular weight of 20,000 to
200,000, the interferon-β being gradually released into a
vitreous body.
Claim 26
Dependent Claim
23 words
The scleral plug according to any one of claims 8 to 25,
wherein the lactic acid units are in L-, D-, or DL-form.
Claim 27
Dependent Claim
16 words
The scleral plug according to any one of claims 8 to 26,
manufactured by compression molding.
References Cited (Backward Citations)
No citation records indexed.
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