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US6346290B1
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Combinatorial synthesis of novel materials
Assignee: Intermolecular Inc
•
Filing: 1998-07-31
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Granted: 2002-02-12
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Expires: 2018-07-31
Abstract
Abstract Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.
Inventors
- 👤 Peter G. Schultz
- 👤 Xiaodong Xiang
- 👤 Isy Goldwasser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 17:47
CPC Classifications
C; C01; C01G; C01G51/00; C01G51/04; C04; C04B; C04B35/00; C04B35/01; C04B35/16; B; B01; B01J; B01J19/00; B01J19/0046; B32; B32B; B32B19/00; B82; B82Y; B82Y30/00; C01G51/40; C01G51/66; C01G51/68; C04B35/45; C04B35/4504; C04B35/4508; C04B35/4521; C04B35/4525; C04B35/50; C04B35/622; C04B35/62218; C23; C23C; C23C14/00; C23C14/04; C23C14/042; C23C14/06; C23C14/08; C23C14/087; C23C14/22; C23C14/34; C23C16/00; C23C16/04; C23C16/042; C40; C40B; C40B40/00; C40B40/04; C40B40/14; C40B40/18; C40B60/00; C40B60/08; C40B80/00; G; G01; G01R; G01R33/00; G01R33/12; G01R33/16; H; H01; H01F; H01F1/00; H01F1/01; H01F1/40; H01F1/401; H01F1/407; H01F10/00; H01F10/007; H01F10/08; H01F10/10; H01F10/18; H01F10/193; H01F10/1933; H01F41/00; H01F41/14; H01F41/18; H01F41/32; H01F41/34; H10; H10N; H10N50/00; H10N50/80; H10N50/85; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00279; B01J2219/00306; B01J2219/00313; B01J2219/00315; B01J2219/00317; B01J2219/00351; B01J2219/00378; B01J2219/00427; B01J2219/0043; B01J2219/00432; B01J2219/00436; B01J2219/00441; B01J2219/00443; B01J2219/00457; B01J2219/00475; B01J2219/00497; B01J2219/005; B01J2219/00511; B01J2219/00513; B01J2219/00515; B01J2219/0052; B01J2219/00527; B01J2219/00531; B01J2219/00533; B01J2219/00536; B01J2219/0054; B01J2219/00583; B01J2219/00585; B01J2219/0059; B01J2219/00592; B01J2219/00596; B01J2219/00603; B01J2219/00605; B01J2219/0061; B01J2219/00612; B01J2219/00614; B01J2219/00617; B01J2219/00619; B01J2219/00621; B01J2219/00623; B01J2219/00626; B01J2219/00628; B01J2219/0063; B01J2219/00632; B01J2219/00635; B01J2219/00637; B01J2219/00639; B01J2219/00644; B01J2219/00646; B01J2219/00648; B01J2219/00659; B01J2219/0068; B01J2219/00686; B01J2219/00689; B01J2219/00691; B01J2219/00709; B01J2219/00711; B01J2219/00718; B01J2219/0072; B01J2219/00722; B01J2219/00736; B01J2219/00745; B01J2219/00747; B01J2219/0075; B01J2219/00752; B01J2219/00754; B82Y25/00; C01P; C01P2002/00; C01P2002/30; C01P2002/34; C01P2002/50; C01P2002/52; C01P2002/70; C01P2002/72; C01P2004/00; C01P2004/80; C01P2004/82; C01P2004/84; C01P2006/00; C01P2006/40; C01P2006/42; C04B2235/00; C04B2235/02; C04B2235/30; C04B2235/32; C04B2235/3205; C04B2235/3206; C04B2235/3208; C04B2235/3213; C04B2235/3215; C04B2235/3224; C04B2235/3225; C04B2235/3227; C04B2235/3262; C04B2235/327; C04B2235/3275; C04B2235/3284; C04B2235/3286; C04B2235/3296; C04B2235/3298; C04B2235/34; C04B2235/3418; C04B2235/3427; C04B2235/3463; C04B2235/65; C04B2235/656; C04B2235/70; C04B2235/74; C04B2235/76; C04B2235/761; C04B2235/762; C04B2235/768; C04B2235/96; C40B30/00; C40B30/08; C40B60/14; C40B70/00; Y; Y10; Y10T; Y10T428/00; Y10T428/24; Y10T428/24479; Y10T428/24612; Y10T428/2462; Y10T428/31; Y10T428/31504; Y10T428/31551; Y10T428/31645; Y10T428/31855; Y10T428/31931; Y10T436/00; Y10T436/25; Y10T436/2525; Y10T436/25375; Y10T436/255; Y10T436/25875
Claims Analysis
Total Claims: 62
Claim 1
Independent Claim
200 words
A method of evaluating an array of polymeric materials, the method comprising preparing an array comprising first and second non-biological organic polymers on a substrate, the first non-biological organic polymer being different from the second non-biological organic polymer, the array being prepared by a method that includes delivering a first component and a second component of the first non-biological organic polymer to a first region of a substrate, delivering a first component and a second component of the second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, and polymerizing the delivered first and second components of the first non-biological organic polymer to form the first non-biological organic polymer at the first region of the substrate, and simultaneously polymerizing the delivered first and second components of the second non-biological organic polymer to form the second non-biological organic polymer at the second region of the substrate, and screening the first and second non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 2
Independent Claim
200 words
A method of evaluating an array of polymeric materials, the method comprising preparing an array comprising first and second non-biological organic polymers on a substrate, the first non-biological organic polymer being different from the second non-biological organic polymer, the array being prepared by a method that includes delivering a first component and a second component of the first non-biological organic polymer to a first region of a substrate, delivering a first component and a second component of the second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, and polymerizing the delivered first and second components of the first non-biological organic polymer to form the first non-biological organic polymer at the first region of the substrate, and simultaneously polymerizing the delivered first and second components of the second non-biological organic polymer to form the second non-biological organic polymer at the second region of the substrate, and screening the first and second non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 3
Dependent Claim
24 words
The method as recited in claim 1 wherein said non-biological organic polymers are selected from the group consisting of homopolymers, copolymers and higher-ordered polymers.
Claim 4
Dependent Claim
28 words
The method as recited in claim 1 wherein said non-biological organic polymers are selected from the group consisting of natural polymers, synthetic polymers, cross-linked polymers and non-cross-linked polymers.
Claim 5
Dependent Claim
28 words
The method of claim 1 wherein said non-biological organic polymers are selected from the group consisting of polyurethanes, polyesters, polycarbonates, polyethyleneimines, polyacetates, polystyrenes, polyamides, polyanilines, polyacetylenes and polypyrroles.
Claim 6
Dependent Claim
34 words
The method as recited in claim 1 wherein said first component of said first material and said second component of said first material are simultaneously delivered to said first region on said single substrate.
Claim 7
Dependent Claim
39 words
The method as recited in claim 1 wherein said first component of said first material and said first component of said second material are simultaneously delivered to said first region and said second region on said single substrate, respectively.
Claim 8
Dependent Claim
32 words
The method as recited in claim 1 wherein said first component of said first material and said first component of said second material are the same, but are offered in different concentrations.
Claim 9
Dependent Claim
32 words
The method as recited in claim 1 wherein said second component of said first material and said second component of said second material are the same, but are offered in different concentrations.
Claim 10
Dependent Claim
27 words
The method as recited in claim 1 wherein the components of said materials are delivered to said first and second regions on said substrate from a dispenser.
Claim 11
Dependent Claim
13 words
The method as recited in claim 9 wherein said dispenser is a pipette.
Claim 12
Dependent Claim
33 words
The method as recited in claim 9 wherein said dispenser is selected from the group consisting of a pulse pressure ink-jet dispenser, a bubble jet ink-jet dispenser and a slit jet ink-jet dispenser.
Claim 13
Dependent Claim
80 words
The method as recited in claim 1 wherein said steps of delivering said components each comprises the following steps: (i) identifying a reference point on said substrate; (ii) moving a dispenser of said component a fixed distance and direction from said reference point such that said dispenser is positioned approximately above said first region of said substrate; (iii) delivering said component to said first region; and (iv) repeating steps (ii) and (iii) for each remaining component for each remaining region.
Claim 14
Dependent Claim
33 words
The method as recited in claim 1 wherein there is a sufficient amount of space between each of said regions on said single substrate such that said components cannot interdiffuse between said regions.
Claim 15
Independent Claim
97 words
A method for evaluating polymeric materials, the method comprising delivering one or more monomers of non-biological organic polymers to ten or more regions of a substrate, delivering an initiator to the ten or more regions of the substrate, simultaneously polymerizing the delivered monomers to form ten or more different non-biological organic polymers on the substrate, and screening the ten or more non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 16
Independent Claim
97 words
A method for evaluating polymeric materials, the method comprising delivering one or more monomers of non-biological organic polymers to ten or more regions of a substrate, delivering an initiator to the ten or more regions of the substrate, simultaneously polymerizing the delivered monomers to form ten or more different non-biological organic polymers on the substrate, and screening the ten or more non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 17
Dependent Claim
15 words
The method of claim 14 wherein the ten or more non-biological organic polymers are homopolymers.
Claim 18
Dependent Claim
15 words
The method of claim 14 wherein the ten or more non-biological organic polymers are copolymers.
Claim 19
Independent Claim
129 words
A method for preparing an array of polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on the substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first non-biological organic polymer, and simultaneously, polymerizing the delivered monomers of the second non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second non-biological organic polymer, the second non-biological organic polymer being different from the first non-biological organic polymer.
Claim 20
Independent Claim
129 words
A method for preparing an array of polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on the substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first non-biological organic polymer, and simultaneously, polymerizing the delivered monomers of the second non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second non-biological organic polymer, the second non-biological organic polymer being different from the first non-biological organic polymer.
Claim 21
Dependent Claim
15 words
The method of claim 17 wherein the first and second non-biological organic polymers are homopolymers.
Claim 22
Dependent Claim
15 words
The method of claim 17 wherein the first and second non-biological organic polymers are copolymers.
Claim 23
Independent Claim
112 words
A method for preparing an array of polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on the substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, to form the first non-biological organic polymer, polymerizing the delivered monomers of the second non-biological organic polymer to form the second non-biological organic polymer, and independently controlling the polymerization reaction conditions at the first region and the second region of the substrate.
Claim 24
Independent Claim
112 words
A method for preparing an array of polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on the substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, to form the first non-biological organic polymer, polymerizing the delivered monomers of the second non-biological organic polymer to form the second non-biological organic polymer, and independently controlling the polymerization reaction conditions at the first region and the second region of the substrate.
Claim 25
Dependent Claim
15 words
The method of claim 20 wherein the first and second non-biological organic polymers are homopolymers.
Claim 26
Dependent Claim
15 words
The method of claim 20 wherein the first and second non-biological organic polymers are copolymers.
Claim 27
Dependent Claim
25 words
The method of claim 20 wherein the delivered first and second components of each of the first and second non-biological organic polymers are simultaneously polymerized.
Claim 28
Dependent Claim
22 words
The method of claim 20 wherein the temperatures at the first region and the second region of the substrate are independently controlled.
Claim 29
Dependent Claim
23 words
The method of claim 20 wherein the reaction times at the first region and the second region of the substrate are independently controlled.
Claim 30
Dependent Claim
23 words
The method of claim 20 wherein the reaction solvents at the first region and the second region of the substrate are independently controlled.
Claim 31
Dependent Claim
23 words
The method of claim 20 wherein the reaction conditions are controllably varied between the first region and the second region of the substrate.
Claim 32
Independent Claim
146 words
A method for preparing an array of polymeric materials, the method comprising forming ten or more different non-biological organic polymers on a substrate, each of the ten or more non-biological organic polymers comprising a first component and a second component, the first component being the same between the ten or more non-biological organic polymers, the polymers being formed by a method that includes delivering the first component of the ten or more non-biological organic polymers in a gradient of stoichiometries to ten or more regions of the substrate, delivering the second component of the ten or more non-biological organic polymers to the ten or more regions of the substrate, delivering an initiator to the ten or more regions of the substrate, and polymerizing the delivered first and second components of the ten or more non-biological organic polymers to form the ten or more non-biological organic polymers.
Claim 33
Independent Claim
146 words
A method for preparing an array of polymeric materials, the method comprising forming ten or more different non-biological organic polymers on a substrate, each of the ten or more non-biological organic polymers comprising a first component and a second component, the first component being the same between the ten or more non-biological organic polymers, the polymers being formed by a method that includes delivering the first component of the ten or more non-biological organic polymers in a gradient of stoichiometries to ten or more regions of the substrate, delivering the second component of the ten or more non-biological organic polymers to the ten or more regions of the substrate, delivering an initiator to the ten or more regions of the substrate, and polymerizing the delivered first and second components of the ten or more non-biological organic polymers to form the ten or more non-biological organic polymers.
Claim 34
Dependent Claim
20 words
The method of claim 28 wherein the second component is the same between the ten or more non-biological organic polymers.
Claim 35
Dependent Claim
40 words
The method of claim 28 wherein the second component is the same between the ten or more non-biological organic polymers, and the second component is delivered in a gradient of stoichiometries to the ten or more regions of the substrate.
Claim 36
Independent Claim
168 words
A method for evaluating polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on a substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first non-biological organic polymer, and simultaneously, polymerizing the delivered monomers of the second non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second non-biological organic polymer, the second non-biological organic polymer being different from the first non-biological organic polymer, and screening the first and second non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 37
Independent Claim
168 words
A method for evaluating polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on a substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first non-biological organic polymer, and simultaneously, polymerizing the delivered monomers of the second non-biological organic polymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second non-biological organic polymer, the second non-biological organic polymer being different from the first non-biological organic polymer, and screening the first and second non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 38
Dependent Claim
60 words
The method of claim 31 wherein the first and second regions of the substrate are defined by physical barriers selected from the group consisting of dimples, wells and vessels, and the first and second non-biological organic polymers are screened in parallel for a property selected from the group consisting of a thermal property, a mechanical property, and a chemical property.
Claim 39
Independent Claim
150 words
A method for evaluating polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on the substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, to form the first non-biological organic polymer, polymerizing the delivered monomers of the second non-biological organic polymer to form the second non-biological organic polymer, independently controlling the polymerization reaction conditions at the first region and the second region of the substrate, and screening the first and second non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 40
Independent Claim
150 words
A method for evaluating polymeric materials, the method comprising delivering one or more monomers of a first non-biological organic polymer to a first region on the substrate, delivering one or more monomers of a second non-biological organic polymer to a second region on the substrate, delivering an initiator to the first and second regions of the substrate, polymerizing the delivered monomers of the first non-biological organic polymer, to form the first non-biological organic polymer, polymerizing the delivered monomers of the second non-biological organic polymer to form the second non-biological organic polymer, independently controlling the polymerization reaction conditions at the first region and the second region of the substrate, and screening the first and second non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 41
Dependent Claim
60 words
The method of claim 33 wherein the first and second regions of the substrate are defined by physical barriers selected from the group consisting of dimples, wells and vessels, and the first and second non-biological organic polymers are screened in parallel for a property selected from the group consisting of a thermal property, a mechanical property, and a chemical property.
Claim 42
Independent Claim
185 words
A method for evaluating polymeric materials, the method comprising forming ten or more different non-biological organic polymers on a substrate, each of the ten or more non-biological organic polymers comprising a first component and a second component, the first component being the same between the ten or more non-biological organic polymers, the polymers being formed by a method that includes delivering the first component of the ten or more non-biological organic polymers in a gradient of stoichiometries to ten or more regions of the substrate, delivering the second component of the ten or more non-biological organic polymers to the ten or more regions of the substrate, delivering an initiator to the ten or more regions of the substrate, and polymerizing the delivered first and second components of the ten or more non-biological organic polymers to form the ten or more non-biological organic polymers, and screening the ten or more non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 43
Independent Claim
185 words
A method for evaluating polymeric materials, the method comprising forming ten or more different non-biological organic polymers on a substrate, each of the ten or more non-biological organic polymers comprising a first component and a second component, the first component being the same between the ten or more non-biological organic polymers, the polymers being formed by a method that includes delivering the first component of the ten or more non-biological organic polymers in a gradient of stoichiometries to ten or more regions of the substrate, delivering the second component of the ten or more non-biological organic polymers to the ten or more regions of the substrate, delivering an initiator to the ten or more regions of the substrate, and polymerizing the delivered first and second components of the ten or more non-biological organic polymers to form the ten or more non-biological organic polymers, and screening the ten or more non-biological organic polymers for a property of interest selected from the group consisting of a thermal property, a mechanical property, a morphological property, a chemical property, an optical property, a magnetic property and an electrical property.
Claim 44
Dependent Claim
60 words
The method of claim 35 wherein the ten or more regions of the substrate are defined by physical barriers selected from the group consisting of dimples, wells and vessels, and the ten or more non-biological organic polymers are screened in parallel for a property selected from the group consisting of a thermal property, a mechanical property and a chemical property.
Claim 45
Independent Claim
16 words
The method as recited in claims 28 or 35 wherein said delivered components are simultaneously polymerized.
Claim 46
Independent Claim
26 words
The method as recited in claims 1 , 17 , 20 , 31 or 33 wherein at least 10 different materials are synthesized on said substrate.
Claim 47
Independent Claim
32 words
The method as recited in claims 1 , 14 , 17 , 20 , 28 , 31 , 33 or 35 wherein at least 100 different materials are synthesized on said substrate.
Claim 48
Independent Claim
24 words
The method as recited in claims 1 , 14 , 17 or 31 wherein at least 1000 different materials are synthesized on said substrate.
Claim 49
Independent Claim
25 words
The method as recited in claims 1 , 14 , 17 or 31 wherein at least 10 6 different materials are synthesized on said substrate.
Claim 50
Independent Claim
40 words
The method as recited in claims 1 , 14 , 17 or 31 wherein at least 100 different materials are synthesized on said substrate, and each different material is contained within an area of about 1 mm 2 or less.
Claim 51
Independent Claim
24 words
The method as recited in claims 1 , 14 , 31 , 33 or 35 wherein said property of interest is an optical property.
Claim 52
Dependent Claim
17 words
The method as recited in claim 43 wherein said optical property is measured using light scattering techniques.
Claim 53
Independent Claim
24 words
The method as recited in claims 1 , 14 , 31 , 33 or 35 wherein said property of interest is a chemical property.
Claim 54
Independent Claim
26 words
The method of claims 1 , 14 , 31 , 33 or 35 wherein the array of non-biological organic polymers is screened for a thermal property.
Claim 55
Independent Claim
26 words
The method of claims 1 , 14 , 31 , 33 or 35 wherein the array of non-biological organic polymers is screened for a mechanical property.
Claim 56
Independent Claim
26 words
The method of claims 1 , 14 , 31 , 33 or 35 wherein the array of non-biological organic polymers is screened for a morphological property.
Claim 57
Independent Claim
24 words
The method as recited in claims 1 , 14 , 31 , 33 or 35 wherein said array of materials is screened in parallel.
Claim 58
Independent Claim
23 words
The method as recited in claims 1 , 14 , 31 , 33 or 35 wherein said array of materials is screened sequentially.
Claim 59
Independent Claim
218 words
A method for evaluating styrene copolymer materials, the method comprising delivering one or more monomers of a first styrene copolymer to a first region on a substrate, the first region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, delivering one or more monomers of a second styrene copolymer to a second region on the substrate, the second region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, the delivery of the one or more monomers of the second styrene copolymer to the second region of the substrate being simultaneous with the delivery of the one or more monomers of the first styrene copolymer to the first region of the substrate, polymerizing the delivered monomers of the first styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first styrene copolymer without covalent bonding to the substrate, and simultaneously, polymerizing the delivered monomers of the second styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second styrene copolymer without covalent bonding to the substrate, the second styrene copolymer being different from the first styrene copolymer, and screening the first and second styrene copolymers in parallel for a chemical property.
Claim 60
Independent Claim
218 words
A method for evaluating styrene copolymer materials, the method comprising delivering one or more monomers of a first styrene copolymer to a first region on a substrate, the first region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, delivering one or more monomers of a second styrene copolymer to a second region on the substrate, the second region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, the delivery of the one or more monomers of the second styrene copolymer to the second region of the substrate being simultaneous with the delivery of the one or more monomers of the first styrene copolymer to the first region of the substrate, polymerizing the delivered monomers of the first styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first styrene copolymer without covalent bonding to the substrate, and simultaneously, polymerizing the delivered monomers of the second styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second styrene copolymer without covalent bonding to the substrate, the second styrene copolymer being different from the first styrene copolymer, and screening the first and second styrene copolymers in parallel for a chemical property.
Claim 61
Independent Claim
207 words
A method for preparing an array of styrene copolymer materials, the method comprising delivering one or more monomers of a first styrene copolymer to a first region on a substrate, the first region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, delivering one or more monomers of a second styrene copolymer to a second region on the substrate, the second region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, the delivery of the one or more monomers of the second styrene copolymer to the second region of the substrate being simultaneous with the delivery of the one or more monomers of the first styrene copolymer to the first region of the substrate, polymerizing the delivered monomers of the first styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first styrene copolymer without covalent bonding to the substrate, and simultaneously, polymerizing the delivered monomers of the second styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second styrene copolymer without covalent bonding to the substrate, the second styrene copolymer being different from the first styrene copolymer.
Claim 62
Independent Claim
207 words
A method for preparing an array of styrene copolymer materials, the method comprising delivering one or more monomers of a first styrene copolymer to a first region on a substrate, the first region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, delivering one or more monomers of a second styrene copolymer to a second region on the substrate, the second region of the substrate being defined by physical barriers selected from the group consisting of dimples, wells and vessels, the delivery of the one or more monomers of the second styrene copolymer to the second region of the substrate being simultaneous with the delivery of the one or more monomers of the first styrene copolymer to the first region of the substrate, polymerizing the delivered monomers of the first styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the first styrene copolymer without covalent bonding to the substrate, and simultaneously, polymerizing the delivered monomers of the second styrene copolymer, such that the monomers react, without linear, stepwise coupling thereof, to form the second styrene copolymer without covalent bonding to the substrate, the second styrene copolymer being different from the first styrene copolymer.
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