US5980972A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of applying drug-release coatings
Assignee: Boston Scientific Scimed Inc
•
Filing: 1997-09-22
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Granted: 1999-11-09
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Expires: 2017-09-22
Abstract
Abstract The invention is directed to a method of applying drug-release coatings whereby a polymer can be dissolved in a first solvent (solvent A) to form a polymer system and a drug can be dissolved or suspended in a second solvent (solvent B) to form a drug system. The coating or layer of coating so formed comprises a substantially uniform combination of the drug and polymer. Solvent B can be the same as or different than solvent A. The coating can be applied on a stent body by separately spraying or dipping the polymer system and the drug system onto the devices. The coating can be accomplished by either applying the polymer and drug systems sequentially or simultaneously. In certain embodiments, a drug can be suspended in solvent B. In some cases, three or more systems can be utilized. For instance, a third system containing pure solvent A or B can smooth the coating surface, if the solvent of the third spraying system is compatible with the polymer matrix.
Inventors
- 👤 Ni Ding
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:24
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6957; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61F; A61F2/00; A61F2/82; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/60; A61L2300/606; A61L2300/608; A61L2420/00; A61L2420/02; B; B05; B05B; B05B13/00; B05B13/02; B05B13/04; B05B13/0442
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
142 words
A method of making a medical device having at least a portion for insertion or implantation into the body of a patient, wherein the portion has a surface which is adapted for exposure to body tissue of the patient and wherein at least a part of the surface is covered with a coating comprising at least one layer, to release at least one biologically active material therefrom, the method comprising: a) applying a thermodynamically stable polymer system substantially free of a biologically active material comprising a polymer and a first solvent of the polymer to the surface, and b) applying a drug system substantially free of any polymer comprising a biologically active material and a second solvent of the biologically active material to the surface; wherein said method forms a substantially homogenous composite layer of the polymer and the biologically active material.
Claim 2
Independent Claim
142 words
A method of making a medical device having at least a portion for insertion or implantation into the body of a patient, wherein the portion has a surface which is adapted for exposure to body tissue of the patient and wherein at least a part of the surface is covered with a coating comprising at least one layer, to release at least one biologically active material therefrom, the method comprising: a) applying a thermodynamically stable polymer system substantially free of a biologically active material comprising a polymer and a first solvent of the polymer to the surface, and b) applying a drug system substantially free of any polymer comprising a biologically active material and a second solvent of the biologically active material to the surface; wherein said method forms a substantially homogenous composite layer of the polymer and the biologically active material.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein steps (a) and (b) are repeated.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the medical device is a stent.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein the stent is a self-expanding stent.
Claim 6
Dependent Claim
15 words
The method of claim 1 wherein the first solvent and second solvent are the same.
Claim 7
Dependent Claim
14 words
The method of claim 1 wherein the first solvent and second solvent are different.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein the polymer is a hydrophobic biostable elastomer.
Claim 9
Dependent Claim
30 words
The method of claim 7, wherein the elastomer is selected from the group consisting of silicones, polyurethanes, thermoplastic elastomers, ethylene vinyl acetate copolymers, polyolefin elastomers, EPDM rubbers and polyamide elastomers.
Claim 10
Dependent Claim
54 words
The method of claim 1 wherein the biologically active material is selected from the group consisting of antithrobotics, anticoagulants, antiplatelet agents, thrombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, smooth muscle cell inhibitors, antibiotics, growth factors, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters and drugs that enhance the formation of healthy neointimal tissue.
Claim 11
Dependent Claim
17 words
The method of claim 1 wherein the polymer system or drug system is applied by spray coating.
Claim 12
Dependent Claim
16 words
The method of claim 1 wherein the polymer system or drug system is applied by dipping.
Claim 13
Dependent Claim
19 words
The method of claim 1 wherein the polymer system and the drug system are applied simultaneously to the surface.
Claim 14
Dependent Claim
19 words
The method of claim 1 wherein the polymer system and the drug system are applied sequentially to the surface.
Claim 15
Dependent Claim
19 words
The method of claim 1 which further comprises partially evaporating the first solvent prior to applying the drug system.
Claim 16
Dependent Claim
16 words
The method of claim 1 wherein the biologically active material is dissolved in the second solvent.
Claim 17
Dependent Claim
16 words
The method of claim 1 wherein the biologically active material is suspended in the second solvent.
Claim 18
Dependent Claim
16 words
The method of claim 1 which further comprises applying a solvent system to the coating layer.
Claim 19
Dependent Claim
27 words
The method of claim 1 which further comprises applying a second drug system substantially free of a polymer comprising a second biologically active material to the surface.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-11-08 | 2003-05-10 | 2003-11-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-11-08 | 2007-05-10 | 2007-11-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-11-08 | 2011-05-10 | 2011-11-09 | $7700.00 | Window Closed / Lapsed |