Patent US5853733A successfully refreshed from Google Patents.
US5853733A
Expired / Lapsed
US
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Recombinant herpesvirus of turkeys and uses thereof
Assignee: Syntro Corp
•
Filing: 1996-06-13
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Granted: 1998-12-29
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Expires: 2016-06-13
Abstract
Abstract The present invention provides a recombinant herpesvirus of turkeys designated S-HVT-050 (ATCC Accession No. VR 2400). A vaccine is provided which comprises an effective immunizing amount of S-HVT-050 and a suitable carrier. A method of immunizing a fowl against disease caused by Marek's disease virus and Newcastle disease virus is also provided which comprises administering to the fowl an effective immunizing dose of the vaccine of the present invention.
Inventors
- 👤 Mark D. Cochran
- 👤 Richard D. Macdonald
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:39
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/63; C12N15/79; C12N15/85; C12N15/86; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16311; C12N2710/16334; C12N2710/16341; C12N2710/16343; C12N2720/00; C12N2720/00011; C12N2720/10011; C12N2720/10034; C12N2760/00; C12N2760/00011; C12N2760/18011; C12N2760/18111; C12N2760/18134; Y; Y10; Y10S; Y10S424/00; Y10S424/816
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
54 words
A recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a herpesvirus of turkeys genome, wherein the foreign DNA is inserted within a region which corresponds to an EcoR1 #9 fragment of the herpesvirus of turkeys genome, and is capable of being expressed in a host cell into which the virus is introduced.
Claim 2
Dependent Claim
54 words
A recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a herpesvirus of turkeys genome, wherein the foreign DNA is inserted within a region which corresponds to an EcoR1 #9 fragment of the herpesvirus of turkeys genome, and is capable of being expressed in a host cell into which the virus is introduced.
Claim 3
Dependent Claim
26 words
The recombinant herpesvirus of turkeys of claim 1, wherein the foreign DNA is inserted within Open Reading Frame A (ORF A) of the EcoR1 #9 fragment.
Claim 4
Dependent Claim
28 words
The recombinant herpesvirus of turkeys of claim 1, wherein the foreign DNA is inserted within a XhoI site of the region which corresponds to the EcoR1 #9 fragment.
Claim 5
Dependent Claim
15 words
The recombinant herpesvirus of turkeys of claim 1, wherein the foreign DNA encodes a polypeptide.
Claim 6
Dependent Claim
16 words
The recombinant herpesvirus of turkeys of claim 1, wherein the foreign DNA encodes E. coli beta-galactosidase.
Claim 7
Dependent Claim
30 words
The recombinant herpesvirus of turkeys of claim 4, wherein the polypeptide is from Marek's Disease Virus, Newcastle Disease Virus, Infectious Laryngotracheitis Virus, Infectious Bronchitis Virus and Infectious Bursal Disease Virus.
Claim 8
Dependent Claim
28 words
The recombinant herpesvirus of turkeys of claim 6, wherein the polypeptide is Marek's Disease Virus glycoprotein A, Marek's Disease Virus glycoprotein B, or Marek's Disease Virus glycoprotein D.
Claim 9
Dependent Claim
22 words
The recombinant herpesvirus of turkeys of claim 6, wherein the polypeptide is Newcastle Disease virus fusion protein or Newcastle Disease virus hemagglutinin-neuraminidase.
Claim 10
Dependent Claim
28 words
The recombinant herpesvirus of turkeys of claim 6, wherein the polypeptide is Infectious Laryngotracheitis Virus glycoprotein B, Infectious Laryngotracheitis Virus glycoprotein I, or Infectious Laryngotracheitis Virus glycoprotein D.
Claim 11
Dependent Claim
23 words
The recombinant herpesvirus of turkeys of claim 6, wherein the polypeptide is Infectious Bronchitis Virus spike protein or Infectious Bronchitis Virus matrix protein.
Claim 12
Dependent Claim
28 words
The recombinant herpesvirus of turkeys of claim 6, wherein the polypeptide is Infectious Bursal Disease Virus VP2, Infectious Bursal Disease Virus VP3 or Infectious Bursal Disease Virus VP4.
Claim 13
Dependent Claim
20 words
The recombinant herpesvirus of turkeys of claim 1, wherein the foreign DNA is under the control of a herpesvirus promoter.
Claim 14
Dependent Claim
20 words
The recombinant herpesvirus of turkeys of claim 1, wherein the foreign DNA is under the control of a heterologous promoter.
Claim 15
Dependent Claim
64 words
The recombinant herpesvirus of turkeys of claim 12, wherein the promoter is Pseudorabies Virus glycoprotein X promoter, Herpes Simplex Virus-1 alpha 4 promoter, Human Cytomegalovirus Immediate Early promoter, Marek's Disease Virus glycoprotein A promoter, Marek's Disease Virus glycoprotein B promoter, Marek's Disease Virus glycoprotein D promoter, Infectious Laryngotracheitis Virus glycoprotein B promoter, Bovine Herpesvirus 1.1 VP8 promoter, or Infectious Laryngotracheitis Virus glycoprotein D promoter.
Claim 16
Dependent Claim
62 words
The recombinant virus of claim 4, wherein the polypeptide obtained is from a group consisting of: avian encephalomyelitis virus, avian reovirus, avian paramyxovirus, avian influenza virus, avian adenovirus, fowl pox virus, avian coronavirus, avian rotavirus, chick anemia virus (agent), Salmonella spp. E. coli, Pasteurella spp., Bordetella spp., Eimeria spp., Histomonas spp., Trichomonas spp., Poultry nematodes, cestodes, trematodes, poultry mites/lice and poultry protozoa.
Claim 17
Dependent Claim
10 words
The recombinant herpesvirus of turkeys of claim 1, designated S-HVT-138.
Claim 18
Dependent Claim
21 words
A vaccine which comprises an effective immunizing amount of the recombinant herpesvirus of turkeys of claim 1 and a suitable carrier.
Claim 19
Dependent Claim
22 words
A method of immunizing a bird which comprises administering to the bird an effecting immunizing dose of the vaccine of claim 17.
Claim 20
Dependent Claim
25 words
The recombinant herpesvirus of turkeys of claim 1, further comprising an additional foreign DNA inserted into the region which corresponds to an EcoR1 #9 fragment.
Claim 21
Dependent Claim
27 words
The recombinant herpesvirus of turkeys of claim 19, wherein the additional foreign DNA is inserted within Open Reading Frame A (ORF A) of the EcoR1 #9 fragment.
Claim 22
Dependent Claim
29 words
The recombinant herpesvirus of turkeys of claim 19, wherein the additional foreign DNA is inserted within the XhoI site of the region which corresponds to the EcoR1 #9 fragment.
Claim 23
Dependent Claim
25 words
The recombinant herpesvirus of turkeys of claim 19, wherein the additional foreign DNA is Infectious Laryngotracheitis Virus glycoprotein B, and Infectious Laryngotracheitis Virus glycoprotein D.
Claim 24
Dependent Claim
24 words
The recombinant herpesvirus of turkeys of claim 19, wherein the additional foreign DNA is Newcastle Disease virus fusion protein and Newcastle Disease virus hemagglutinin-neuraminidase.
Claim 25
Dependent Claim
35 words
The recombinant herpesvirus of turkeys of claim 1, further comprising one or more foreign DNA inserted within the StuI site within the US2 gene of the Unique short region of the herpesvirus of turkeys genome.
Claim 26
Dependent Claim
29 words
The recombinant herpesvirus of turkeys of claim 24, wherein the foreign DNA is Marek's Disease Virus glycoprotein A, Marek's Disease Virus glycoprotein B, and Marek's Disease Virus glycoprotein D.
Claim 27
Dependent Claim
23 words
The recombinant herpesvirus of turkeys of claim 24, wherein the foreign DNA is Newcastle Disease virus fusion protein and Newcastle Disease virus hemagglutinin-neuraminidase.
Claim 28
Dependent Claim
38 words
The recombinant herpesvirus of turkeys of claim 24, wherein the foreign DNA is Marek's Disease Virus glycoprotein A, Marek's Disease Virus glycoprotein B, Marek's Disease Virus glycoprotein D, Newcastle Disease virus fusion protein and Newcastle Disease virus hemagglutinin-neuraminidase.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-12-28 | 2002-06-29 | 2002-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-12-28 | 2006-06-29 | 2006-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-12-28 | 2010-06-29 | 2010-12-29 | $7700.00 | Window Closed / Lapsed |