US5792445A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymers and copolymers of acrylic acid MRI of the digestive tract of patients
Assignee: Bracco International BV
•
Filing: 1996-02-07
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Granted: 1998-08-11
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Expires: 2016-02-07
Abstract
Abstract Suspensions of either echogenic or magnetic particles in aqueous bioadhesive carriers effectively improve imaging by echography, respectively NMRI, of the digestive tract. Affinity of the compositions for the gastric mucosa can be adapted to the needs by appropriately selecting the carrier in function to inherent bioadhesive capacity: this technique leads to improved visualization of selected portions of the lumen.
Inventors
- 👤 Herve Tournier
- 👤 Roland Hyacinthe
- 👤 Friedrich Cavagna
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:35
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1833; A61K49/1845; A61K49/1851; A61K49/1854; A61K49/1863; A61K49/189; A61K49/1893; A61K49/22; A61K49/222; A61K49/223; A61K49/226; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
101 words
A method of manufacturing an ingestible composition for enhancing contrast in NMR imaging of the digestive tract of humans and animals, said composition comprising magnetically responsive particles bound to a polymer or copolymer of acrylic acid, the method comprising: (a) selecting a coupler with at least two reactive functions, wherein one of said reactive functions is a double bond capable of copolymerizing with acrylic acid; (b) grafting the coupler to said magnetically responsive particles through one of said reactive functions and; (c) binding said grafted particles to said polymer or copolymer of acrylic acid through the other of said reactive functions.
Claim 2
Independent Claim
101 words
A method of manufacturing an ingestible composition for enhancing contrast in NMR imaging of the digestive tract of humans and animals, said composition comprising magnetically responsive particles bound to a polymer or copolymer of acrylic acid, the method comprising: (a) selecting a coupler with at least two reactive functions, wherein one of said reactive functions is a double bond capable of copolymerizing with acrylic acid; (b) grafting the coupler to said magnetically responsive particles through one of said reactive functions and; (c) binding said grafted particles to said polymer or copolymer of acrylic acid through the other of said reactive functions.
Claim 3
Dependent Claim
27 words
The method of claim 1, wherein one reactive function of the coupler is a trialkoxy-silane function which binds to the magnetic particles by forming a silicon-containing bond.
Claim 4
Dependent Claim
36 words
A The method of claim 1, wherein the polymer or copolymer of acrylic acid further comprises polymers having carboxy, sulfate, sulfonate, phospahte and phosphonate groups free or in the form of alkali- or alkaline-earth metal salts.
Claim 5
Dependent Claim
20 words
A The method of claim 3, wherein the polymer or copolymer of acrylic acid comprises polysulfated or polyphosphonated carbohydrate polymers.
Claim 6
Dependent Claim
31 words
The method of claim 1, wherein the polymer or copolymer of acrylic acid is further admixed with magnesium alginate, pectin, hydroxylated coatable polysaccharides or Attapulgite clay, Montmorillonite clay or mixtures thereof.
Claim 7
Dependent Claim
40 words
The method of claim 1, said composition further comprises a dispersion of contrast-enhancing particles in an aqueous solution of a water-soluble polymer carrier, the amount of said contrast-enhancing particles to said water-soluble polymer carrier, measured dry, not exceeding 5% wt.
Claim 8
Dependent Claim
42 words
The method of claim 6, wherein the proportion of said dispersion is up to 99% of the total of the composition, and the water-soluble polymer carrier is selected from the group consisting of dextran, poliyvinylpyrrolidone, carboxymethyl-cellulose, hydroxypropyl-cellulose and other water-soluble non-metabolizable polymers.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-08-10 | 2002-02-09 | 2002-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-08-10 | 2006-02-09 | 2006-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-08-10 | 2010-02-09 | 2010-08-11 | $7700.00 | Window Closed / Lapsed |