US5393525A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration
Assignee: GE Healthcare AS
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Filing: 1994-03-21
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Granted: 1995-02-28
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Expires: 2014-03-21
Abstract
Abstract There is provided a contrast medium composition comprising magnetically responsive particles and a physiologically tolerable, incompletely hydrated viscosity enhancing agent.
Inventors
- 👤 Helge G. Gundersen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:54
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/1887; A61K49/1803; A61K49/1821; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
60 words
A contrast medium composition for administration to a patient for MR imaging comprising a pulverulent mixture of superparamagnetic, ferrimagnetic or ferromagnetic particles together with a physiologically tolerable viscosity enhancing agent, such that following dispersion of said composition in a physiologically tolerable carrier fluid it may be administered to said patient with the viscosity of the composition increasing after such administration.
Claim 2
Dependent Claim
60 words
A contrast medium composition for administration to a patient for MR imaging comprising a pulverulent mixture of superparamagnetic, ferrimagnetic or ferromagnetic particles together with a physiologically tolerable viscosity enhancing agent, such that following dispersion of said composition in a physiologically tolerable carrier fluid it may be administered to said patient with the viscosity of the composition increasing after such administration.
Claim 3
Dependent Claim
19 words
A composition as claimed in claim 1 comprising a said viscosity enhancing agent provided with a delayed release coating.
Claim 4
Dependent Claim
21 words
A composition as claimed in claim 2 comprising a said viscosity enhancing agent provided with a gastric fluid-resistant delayed release coating.
Claim 5
Dependent Claim
14 words
A composition as claimed in claim 1 wherein said viscosity enhancing agent is non-biodegradable.
Claim 6
Dependent Claim
27 words
A composition as claimed in claim 1 wherein said viscosity enhancing agent is water-soluble, water-swellable, or is a bulking agent, or comprises a mixture of such materials.
Claim 7
Dependent Claim
20 words
A composition as claimed in claim 1, wherein said viscosity enhancing agent achieves a viscosity of 200-500 cps upon hydration.
Claim 8
Dependent Claim
28 words
A composition as claimed in claim 1, wherein said viscosity enhancing agent achieves a maximum viscosity within 15 seconds to 60 minutes of contact with an aqueous medium.
Claim 9
Dependent Claim
27 words
A composition as claimed in claim 1, wherein said viscosity enhancing agent achieves a maximum viscosity after at least two minutes of contact with an aqueous medium.
Claim 10
Dependent Claim
21 words
A composition as claimed in claim 1, wherein said viscosity enhancing agent constitutes 1 to 99.5% by weight of the composition.
Claim 11
Dependent Claim
27 words
A composition as claimed in claim 1, wherein said magnetically responsive particles are selected from particles of magnetite, gamma ferric oxide, and cobalt, nickel and manganese ferrites.
Claim 12
Dependent Claim
67 words
A method of generating a magnetic resonance image of a human or non-human animal body, said method comprising administering to an externally voided body cavity of said body a composition as claimed in claim 1, after dispersion thereof in a physiologically tolerable aqueous medium and before complete hydration of the viscosity enhancing agent therein, and generating a magnetic resonance image of at least part of said body.
Claim 13
Dependent Claim
27 words
A diagnostic contrast agent kit comprising a plurality of superparamagnetic, ferrimagnetic or ferromagnetic particles and, packaged separately thereto, a physiologically tolerable viscosity enhancing agent in pulverulent form.
Claim 14
Dependent Claim
27 words
A diagnostic contrast agent kit comprising a plurality of superparamagnetic, ferrimagnetic or ferromagnetic particles and, packaged separately thereto, a physiologically tolerable viscosity enhancing agent in pulverulent form.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-02-27 | 1998-08-29 | 1999-02-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-02-27 | 2002-08-29 | 2003-02-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-02-27 | 2006-08-29 | 2007-02-28 | $7700.00 | Window Closed / Lapsed |