US5346690A
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US
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Composition of a superparamagnetic or ferromagnetic particle and an X-ray contrast agent for MRI
Assignee: GE Healthcare AS
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Filing: 1990-07-19
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Granted: 1994-09-13
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Expires: 2010-07-19
Abstract
Abstract PCT No. PCT/EP90/01195 Sec. 371 Date Jan. 21, 1992 Sec. 102(e) Date Jan. 21, 1992 PCT Filed Jul. 19, 1990 PCT Pub. No. WO91/01147 PCT Pub. Date Feb. 7, 1991.There is provided a magnetic resonance contrast medium comprising magnetically responsive particles and a physiologically tolerable osmoactive agent.
Inventors
- 👤 Helge G. Gundersen
- 👤 Jo Klaveness
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:38
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1806; A61K49/04; A61K49/0433; A61K49/0438; A61K49/0447; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
38 words
A contrast medium for enteral use comprising superparamagnetic, ferrimagnetic and ferromagnetic particles and, as a separate chemical entity, a physiologically tolerable osmoactive iodinated X-ray contrast agent, wherein said osmoactive agent is present at a concentration of 10-800 mmol/l.
Claim 2
Dependent Claim
38 words
A contrast medium for enteral use comprising superparamagnetic, ferrimagnetic and ferromagnetic particles and, as a separate chemical entity, a physiologically tolerable osmoactive iodinated X-ray contrast agent, wherein said osmoactive agent is present at a concentration of 10-800 mmol/l.
Claim 3
Dependent Claim
27 words
A contrast medium as claimed in claim 1, wherein said particles are coated by or embedded in or on particles of a physiologically tolerable non-magnetic carrier material.
Claim 4
Dependent Claim
10 words
A contrast medium as claimed claim 1 containing superparamagnetic particles.
Claim 5
Dependent Claim
25 words
A contrast medium as claimed in claim 1 containing particles of material selected from ferrite, gamma ferric oxide, magnetite and cobalt, nickel and manganese ferrites.
Claim 6
Dependent Claim
19 words
A contrast medium as claimed in claim 1, wherein said particles have a diameter of less than 5 micrometers.
Claim 7
Dependent Claim
16 words
A contrast medium as claimed in claim 1 further containing a physiologically tolerable viscosity enhancing agent.
Claim 8
Dependent Claim
49 words
A method of generating a magnetic resonance image of a human or nonhuman mammalian body, said method comprising administering to an externally voided body cavity of said body a contrast medium as claimed in claim 1 and generating a magnetic resonance image of at least part of said body.
Claim 9
Dependent Claim
25 words
A contrast medium as claimed in claim 2 containing particles of material selected from ferrite, gamma ferric oxide, magnetite and cobalt, nickel and manganese ferrites.
Claim 10
Dependent Claim
25 words
A contrast medium as claimed in claim 3 containing particles of material selected from ferrite, gamma ferric oxide, magnetite and cobalt, nickel and manganese ferrites.
Claim 11
Dependent Claim
19 words
A contrast medium as claimed in claim 2 wherein said particles have a diameter of less than 5 micrometers.
Claim 12
Dependent Claim
19 words
A contrast medium as claimed in claim 3 wherein said particles have a diameter of less than 5 micrometers.
Claim 13
Dependent Claim
19 words
A contrast medium as claimed in claim 4 wherein said particles have a diameter of less than 5 micrometers.
Claim 14
Dependent Claim
16 words
A contrast medium as claimed in claim 2 further comprising a physiologically tolerable viscosity enhancing agent.
Claim 15
Dependent Claim
15 words
A contrast medium as claimed in claim 3 comprising a physiologically tolerable viscosity enhancing agent.
Claim 16
Dependent Claim
16 words
A contrast medium as claimed in claim 4 further comprising a physiologically tolerable viscosity enhancing agent.
Claim 17
Dependent Claim
16 words
A contrast medium as claimed in claim 5 further comprising a physiologically tolerable viscosity enhancing agent.
Claim 18
Dependent Claim
45 words
A method of generating a magnetic resonance image of a gastrointestinal tract of a human or non-human mammalian body, said method comprising administering to the gastrointestinal tract a contrast medium as claimed in claim 1 and generating a magnetic resonance image of the gastrointestinal tract.
Claim 19
Dependent Claim
14 words
A method according to claim 17 wherein the iodinated X-ray contrast agent is non-ionic.
Claim 20
Dependent Claim
23 words
A diagnostic contrast agent kit comprising a plurality of superparamagnetic, ferrimagnetic or ferromagnetic particles and, packaged separately thereto, a physiologically tolerable osmoactive agent.
Claim 21
Dependent Claim
23 words
A diagnostic contrast agent kit comprising a plurality of superparamagnetic, ferrimagnetic or ferromagnetic particles and, packaged separately thereto, a physiologically tolerable osmoactive agent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-09-12 | 1998-03-14 | 1998-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-09-12 | 2002-03-14 | 2002-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-09-12 | 2006-03-14 | 2006-09-13 | $7700.00 | Window Closed / Lapsed |