US5370901A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
Assignee: Bracco Suisse SA
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Filing: 1992-01-23
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Granted: 1994-12-06
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Expires: 2012-01-23
Abstract
Abstract Method of making an ingestible composition useful as a contrast enhancing agent in ultrasonic imaging of the digestive tract of humans and animals, wherein the composition has microballoons as contrast enhancing particles bound to an organic carrier phase, which when hydrated has an adhesive affinity for the gastrointestinal mucosa. Method includes grafting a silane coupler having at least two reactive functions to the microballoons through one of the reactive functions and binding the grafted microballoons to the carrier phase through another reactive function.
Inventors
- 👤 Herve Tournier
- 👤 Roland Hyacinthe
- 👤 Friedrich Cavagna
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:41
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1833; A61K49/1845; A61K49/1851; A61K49/1854; A61K49/1863; A61K49/189; A61K49/1893; A61K49/22; A61K49/222; A61K49/223; A61K49/226; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
99 words
A method of making an ingestible composition useful as a contrast enhancing agent in the ultrasonic imaging of the digestive tract of humans and animals, said composition consisting essentially of organic microballoons as contrast enhancing particles bound to an organic carrier phase which when hydrated has an adhesive affinity for the gastrointestinal mucosa, said method comprising the steps of: selecting a silane coupler having at least two reactive functions: grafting said coupler to said microballoons through one of said at least two reactive functions: and binding said grafted microballoons to said carrier phase through another of said reactive functions.
Claim 2
Independent Claim
99 words
A method of making an ingestible composition useful as a contrast enhancing agent in the ultrasonic imaging of the digestive tract of humans and animals, said composition consisting essentially of organic microballoons as contrast enhancing particles bound to an organic carrier phase which when hydrated has an adhesive affinity for the gastrointestinal mucosa, said method comprising the steps of: selecting a silane coupler having at least two reactive functions: grafting said coupler to said microballoons through one of said at least two reactive functions: and binding said grafted microballoons to said carrier phase through another of said reactive functions.
Claim 3
Dependent Claim
31 words
The method of claim 1, wherein said organic substrate is a polymer of acrylic acid and said coupler is selected such that said another reactive function is copolymerizable with acrylic acid.
Claim 4
Dependent Claim
36 words
The method of claim 1, wherein said organic carrier phase is a copolymer of acrylic acid and another copolymerizable monomer and said coupler is selected such that said another reactive function is copolymerizable with acrylic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-12-05 | 1998-06-06 | 1998-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-12-05 | 2002-06-06 | 2002-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-12-05 | 2006-06-06 | 2006-12-06 | $7700.00 | Window Closed / Lapsed |