US5711958A
Expired / Lapsed
US
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Methods for reducing or eliminating post-surgical adhesion formation
Assignee: Yissum Research Development Co of Hebrew University of Jerusalem
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Filing: 1996-07-11
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Granted: 1998-01-27
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Expires: 2016-07-11
Abstract
Abstract The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition comprising chain-extended poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.
Inventors
- 👤 Daniel Cohn
- 👤 Eli Pines
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:00
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/44; A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A61K31/77; A61K31/785; A61L; A61L31/00; A61L31/04; A61L31/06; A61P; A61P41/00; A61P43/00; C08G63/00; C08G63/02; C08G63/06; C08G63/08; C08G63/66; C08G63/664
Claims Analysis
Total Claims: 50
Claim 1
Independent Claim
81 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks, where A is an aliphatic polyester and B is a polyoxyalkylene polymer unit, said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 2
Independent Claim
81 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/poly(oxyalkylene) ABA triblocks, where A is an aliphatic polyester and B is a polyoxyalkylene polymer unit, said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 3
Dependent Claim
14 words
The method according to claim 1 wherein said polyester comprises poly(aliphatic α-hydroxy carboxylic acid).
Claim 4
Dependent Claim
38 words
The method according to claim 2 wherein said polyester is obtained from polymerization of an aliphatic hydroxycarboxylic acid or ester selected from the group consisting of L-lactic acid, D,L-lactic acid, glycolic acid, L-lactide, D,L-lactide, glycolide and mixtures thereof.
Claim 5
Dependent Claim
23 words
The method according to claim 1 wherein said poly(oxyalkylene) polymer is comprised of a poly(ethylene oxide) homopolymer or poly(ethylene oxide)-co-poly(propylene oxide) block copolymer.
Claim 6
Dependent Claim
55 words
The method according to claim 1 wherein said polyester comprises units of an aliphatic hydroxycarboxylic acid or the corresponding cyclic dimeric ester selected from the group consisting of L-lactic acid, D,L-lactic acid, glycolic acid, L-lactide, D,L-lactide, glycolide and mixtures and said poly(oxyalkylene)polymer is comprised of a poly(ethylene oxide) homopolymer or poly(ethylene oxide)-co-poly(propylene oxide) block copolymer.
Claim 7
Dependent Claim
37 words
The method according to claim 5 wherein said A block is between about 4 and 50 carboxylic acid units in length and said B block varies in molecular weight from about 200 Da to about 200,000 Da.
Claim 8
Dependent Claim
28 words
The method according to claim 6 wherein said A block comprises carboxylic acid units derived from L-lactide or D,L-lactide and said B block is comprised of poly(ethylene oxide).
Claim 9
Dependent Claim
39 words
The method according to claim 7 wherein said A block is approximately 6 to 30 carboxylic acid units in length and said B block is comprised of poly(ethylene oxide) having a molecular weight of between 1,500 and 10,000 Da.
Claim 10
Dependent Claim
41 words
The method according to claim 1 wherein said composition is in the form of a preformed structure which is selected from the group consisting of film, rod, tube, bead, a foam, ring, a dispersion, suspension, gel, liquid, spray and viscous solution.
Claim 11
Dependent Claim
14 words
The method according to claim 1 wherein said composition further includes a bioactive agent.
Claim 12
Independent Claim
137 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure: ##STR5## where m, a and b are positive integers, R is an ethylene group and/or propylene group with the proviso that R is not exclusively a propylene group when m is more than 1, R' is a C 2 to C 8 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'-diphenylmethane, toluene, naphthalene, 4,4'-dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene or p-phenylene and R 1 is H or CH 3 , said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 13
Independent Claim
137 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure: ##STR5## where m, a and b are positive integers, R is an ethylene group and/or propylene group with the proviso that R is not exclusively a propylene group when m is more than 1, R' is a C 2 to C 8 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'-diphenylmethane, toluene, naphthalene, 4,4'-dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene or p-phenylene and R 1 is H or CH 3 , said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 14
Dependent Claim
13 words
The method according to claim 11 wherein R 1 is CH 3 .
Claim 15
Dependent Claim
24 words
The method according to claim 11 wherein m is 4 to about 5,000, R 1 is CH 3 and R is an ethylene group.
Claim 16
Dependent Claim
25 words
The method according to claim 11 wherein m is about 30 to about 230, R 1 is CH 3 and R is an ethylene group.
Claim 17
Dependent Claim
14 words
The method according to claim 11 wherein R' is a C 6 alkylene group.
Claim 18
Dependent Claim
34 words
The method according to claim 11 wherein said composition is in the form of a preformed structure which a film, rod, tube, bead, foam, ring, viscous liquid, dispersion, suspension, viscous solution, spray and gel.
Claim 19
Dependent Claim
14 words
The method according to claim 11 wherein a and b are the same integer.
Claim 20
Dependent Claim
14 words
The method according to claim 11 wherein said polymeric composition includes a bioactive agent.
Claim 21
Independent Claim
148 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure: ##STR6## where m, x and y are positive integers, R is an ethylene and/or propylene group with the proviso that R is not exclusively a propylene group when m is greater than 1, R 1 is a hydrogen or methyl group, R" is a C 0 to C 12 alkylene group or a hydroxyl or carboxylic acid substituted alkyl group, a cycloalkyl, a hydroxyl-containing cyclo alkyl, or cycloalkyl-containing group, an aryl or aryl-containing group, or a polyoxyalkylene chain comprised of poly(ethylene oxide) or poly(ethylene oxide)-co-poly(propylene oxide), said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 22
Independent Claim
148 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure: ##STR6## where m, x and y are positive integers, R is an ethylene and/or propylene group with the proviso that R is not exclusively a propylene group when m is greater than 1, R 1 is a hydrogen or methyl group, R" is a C 0 to C 12 alkylene group or a hydroxyl or carboxylic acid substituted alkyl group, a cycloalkyl, a hydroxyl-containing cyclo alkyl, or cycloalkyl-containing group, an aryl or aryl-containing group, or a polyoxyalkylene chain comprised of poly(ethylene oxide) or poly(ethylene oxide)-co-poly(propylene oxide), said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 23
Dependent Claim
13 words
The method according to claim 19 wherein R 1 is CH 3 .
Claim 24
Dependent Claim
24 words
The method according to claim 19 wherein m is 4 to about 5,000, R 1 is CH 3 and R is an ethylene group.
Claim 25
Dependent Claim
25 words
The method according to claim 19 wherein m is about 30 to about 230, R 1 is CH 3 and R is an ethylene group.
Claim 26
Dependent Claim
14 words
The method according to claim 21 wherein R" is a C 6 alkylene group.
Claim 27
Dependent Claim
42 words
The method according to claim 19 wherein said composition is in the form of a preformed structure which is selected from the group consisting of a film, rod, tube, bead, foam, ring, a viscous liquid, gel, dispersion, suspension, spray and viscous solution.
Claim 28
Dependent Claim
13 words
The method according to claim 19 wherein said composition includes a bioactive agent.
Claim 29
Independent Claim
148 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure: ##STR7## where j, k and m are positive integers, R is an ethylene or propylene group with the proviso that R is not exclusively a propylene group when m is greater than 1, R' is a C 2 to C 12 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'-diphenylmethane, toluene, naphthalene, 4,4'-dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene or p-phenylene, R'" is a polyoxyalkylene chain comprising poly(ethylene oxide) or poly(ethylene oxide)-co-poly(propylene oxide) and R 1 is H or CH 3 , said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 30
Independent Claim
148 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure: ##STR7## where j, k and m are positive integers, R is an ethylene or propylene group with the proviso that R is not exclusively a propylene group when m is greater than 1, R' is a C 2 to C 12 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'-diphenylmethane, toluene, naphthalene, 4,4'-dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene or p-phenylene, R'" is a polyoxyalkylene chain comprising poly(ethylene oxide) or poly(ethylene oxide)-co-poly(propylene oxide) and R 1 is H or CH 3 , said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 31
Dependent Claim
13 words
The method according to claim 26 wherein R 1 is CH 3 .
Claim 32
Dependent Claim
24 words
The method according to claim 26 wherein m is 4 to about 5,000, R 1 is CH 3 and R is an ethylene group.
Claim 33
Dependent Claim
25 words
The method according to claim 26 wherein m is about 30 to about 230, R 1 is CH 3 and R is an ethylene group.
Claim 34
Dependent Claim
14 words
The method according to claim 26 wherein R' is a C 6 alkylene group.
Claim 35
Dependent Claim
42 words
The method according to claim 26 wherein said composition is in the form of a preformed structure which is selected from the group consisting of a film, rod, tube, bead, foam ring, a viscous liquid, dispersion, suspension, viscous solution, spray and gel.
Claim 36
Dependent Claim
14 words
The method according to claim 26 wherein j and k are the same integer.
Claim 37
Dependent Claim
14 words
The method according to claim 26 wherein said polymeric composition includes a bioactive agent.
Claim 38
Dependent Claim
21 words
The method according to claim 26 where R'" has a molecular weight ranging from about 200 Da to about 10,000 Da.
Claim 39
Dependent Claim
17 words
The method according to claim 26 wherein R' is a C 2 to C 8 alkylene group.
Claim 40
Independent Claim
86 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/polyethylene oxide ABA triblocks, where said A block comprises an aliphatic polyester and said B block comprises poly(ethyleneoxide) or poly(ethyleneoxide)-co-poly(propylene oxide), said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 41
Independent Claim
86 words
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers which are chain-extended, substantially non-water soluble poly(hydroxy-carboxylic acid)/polyethylene oxide ABA triblocks, where said A block comprises an aliphatic polyester and said B block comprises poly(ethyleneoxide) or poly(ethyleneoxide)-co-poly(propylene oxide), said polymeric composition comprising no more than about 1.0% by weight crosslinking and having an EO/LA ratio ranging from about 0.5 to 5.0.
Claim 42
Dependent Claim
22 words
The method according to claim 36 wherein said poly(hydroxy-carboxylic acid) is derived from lactic acid, glycolic acid, lactide, glycolide or mixtures, thereof.
Claim 43
Dependent Claim
17 words
The method according to claim 37 wherein said polymeric composition comprises no more than about 0.05% crosslinking.
Claim 44
Dependent Claim
14 words
The method according to claim 37 wherein said poly(hydroxy-carboxylic acid) is derived from lactide.
Claim 45
Dependent Claim
16 words
The method according to claim 37, wherein said EO/LA ratio ranges from about 2.0 to 5.0.
Claim 46
Dependent Claim
16 words
The method according to claim 39 wherein said EO/LA ratio ranges from about 2.5 to 40.
Claim 47
Dependent Claim
17 words
The method according to claim 1 wherein said polymeric composition comprises no more than about 0.05% crosslinking.
Claim 48
Dependent Claim
17 words
The method according to claim 11 wherein said polymeric composition comprises no more than about 0.05% crosslinking.
Claim 49
Dependent Claim
17 words
The method according to claim 19 wherein said polymeric composition comprises no more than about 0.05% crosslinking.
Claim 50
Dependent Claim
17 words
The method according to claim 26 wherein said polymeric composition comprises no more than about 0.05% crosslinking.
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