EP0737703A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Hydrogel-forming , self-solvating absorbable polyester copolymers, and methods for use therefor
Assignee: Poly Med Inc
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Filing: 1996-04-12
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Granted: —
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Expires: 2016-04-12
Abstract
Abstract The present invention provides novel hydrogel-forming, self-solvatirig, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting aqueous environment. Pharmaceutical formulations comprising the novel polyester copolymers of the invention are also disclosed which provide a protective barrier to prevent post-surgical adhesion, can be used to treat of defects in conduits such as blood vessels, and for controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.
Inventors
- 👤 Shalaby W. Shalaby
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 16:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/30; A61K47/34; A61L; A61L31/00; A61L31/04; A61L31/06; A61L31/14; A61L31/145; C; C08; C08G; C08G63/00; C08G63/66; C08G63/664
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
22 words
A hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 2
Dependent Claim
21 words
The copolymer of claim 1, wherein said copolymer comprises a hydrophobic polyester block X covalently bonded to a hydrophilic block Y.
Claim 3
Dependent Claim
15 words
The copolymer of any one of claims 1 or 2, wherein said copolymer is carboxy-terminated.
Claim 4
Dependent Claim
37 words
The copolymer of any one of claims 1 to 3, wherein said blocks X and Y are covalently bonded together in an arrangement selected from the group consisting of X-Y-X, (X-Y) n , and branched structures thereof.
Claim 5
Dependent Claim
25 words
The copolymer of any one of claims 1 to 4, wherein said hydrophilic block Y comprises less than 50% of the mass of said copolymer.
Claim 6
Dependent Claim
25 words
The copolymer of any one of claims 1 to 5, wherein said hydrophilic block Y comprises oxyethylene or a combination of oxyethylene and oxypropylene sequences.
Claim 7
Dependent Claim
25 words
The copolymer of any one of claims 1 to 6, wherein said hydrophobic block X comprises more than 50% of the mass of said copolymer.
Claim 8
Dependent Claim
28 words
The copolymer of any one of claims 1 to 7, wherein said hydrophobic block is derived from ring opening polymerization of lactones or step-growth formation of alkylene oxalates.
Claim 9
Dependent Claim
19 words
The copolymer of any one of claims 1 to 8, wherein said hydrogel mass is reversible into a liquid.
Claim 10
Dependent Claim
15 words
The copolymer of any one of claims 1 to 9, wherein said copolymer is extrudable.
Claim 11
Dependent Claim
20 words
The copolymer of claim 10, wherein said extrudable copolymer is a liquid which can be injected into a biological site.
Claim 12
Dependent Claim
26 words
The copolymer of claim 11, wherein said liquid is obtained by combining a high molecular weight sample of said copolymer with a lower molecular weight component.
Claim 13
Dependent Claim
14 words
The copolymer of claim 12, wherein said lower molecular weight component is a plasticizer.
Claim 14
Dependent Claim
25 words
The copolymer of claim 13, wherein said plasticizer comprises said polymer wherein the hydrophilic block Y to hydrophobic block X ratio is greater than 1.
Claim 15
Dependent Claim
28 words
A composition comprising: the copolymer of any one of claims 1 to 14; and a biologically active agent or mixture of biologically active agents associated with said copolymer.
Claim 16
Dependent Claim
11 words
The composition of claim 15, wherein said agents are therapeutic agents.
Claim 17
Dependent Claim
19 words
The composition of claims 15 or 16, wherein said agent or mixture of agents is bonded to said copolymer.
Claim 18
Dependent Claim
28 words
The composition of any one of claims 15 to 17, wherein said agent or mixture of agents is at least partially deposited on an absorbable, microparticulate solid carrier.
Claim 19
Dependent Claim
26 words
The composition of any one of claims 15 to 18, wherein said agent or said mixture of agents is associated with the copolymer via said carrier.
Claim 20
Dependent Claim
14 words
The composition of claims 18 or 19, wherein the carrier is a microporous carrier.
Claim 21
Dependent Claim
21 words
The composition of any one of claims 15 to 20, wherein a low molecular weight component is associated with said copolymer.
Claim 22
Dependent Claim
14 words
The composition of claim 21, wherein said low molecular weight component is a plasticizer.
Claim 23
Dependent Claim
25 words
The composition of claim 22, wherein said plasticizer comprises said polymer wherein the hydrophilic block Y to hydrophobic block X ratio is greater than 1.
Claim 24
Dependent Claim
32 words
A pharmaceutical formulation comprising a copolymer according to any one of claims 1 to 14 or a composition according to any one of claims 15 to 23 and a pharmaceutically acceptable carrier.
Claim 25
Dependent Claim
15 words
A vaccine formulation comprising the pharmaceutical formulation of claim 24 and a pharmaceutically acceptable carrier.
Claim 26
Dependent Claim
39 words
A biomedical barrier for use in treating a person suffering from a condition, said barrier comprising the copolymer according to any one of claims 1 to 14 or a composition according to any one of claims 15 to 23.
Claim 27
Dependent Claim
13 words
The biomedical barrier of claim 26, wherein said barrier is a sterilized barrier.
Claim 28
Dependent Claim
86 words
The pharmaceutical of claim 24 or the biomedical barrier of claim 26 or claim 27 formulated for treating a condition selected from cutaneous, transcutaneous, intracutaneous and/or percutaneous diseases and infections; vascular, oral, ophthalmic, orthopedic or abdominal sites; post-surgical adhesion; defects in conduits such as blood vessels; tissue wounds, traumatized tissues, including burns and skin wounds, compromised wounds, such as ulcers and infected wounds; tissue regeneration and diseases of the periodontium, dry socket; and bone, skin, mucus membrane infections, including those of the vaginal type, and epilepsy.
Claim 29
Dependent Claim
20 words
The pharmaceutical of claim 24 or the biomedical barrier of claim 26 or claim 27 formulated as an anaesthetic agent.
References Cited (Backward Citations)
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