US4346709A
Expired / Lapsed
US
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Drug delivery devices comprising erodible polymer and erosion rate modifier
Assignee: Alza Corp
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Filing: 1980-11-10
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Granted: 1982-08-31
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Expires: 2000-11-10
Abstract
Abstract Erodible devices are disclosed for delivering a drug to an environment of use. The devices comprise a body sized and adapted for delivering the drug to the environment of use, which body comprises (1) a poly(orthoester) or a poly(orthocarbonate) having a repeating unit consisting of a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## wherein R 1 is a multivalent hydrocarbon radical, R 2 and R 3 are hydrocarbon radicals with at least one of the R 2 or R 3 bonded to the dioxycarbon through an oxygen covalent bond, (2) a beneficial drug, and (3) an erosion rate modifier. The devices are useful for delivering both locally and systemically acting drugs over a prolonged period of time. A composition of matter is also disclosed comprising the poly(orthoesters) or the poly(orthocarbonates) and an erosion rate modifier.
Inventors
- 👤 Edward E. Schmitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:46
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K9/0048; A61K9/0051; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; C; C08; C08K; C08K5/00; C08K5/04; C08K5/09; C08K5/098
Claims Analysis
Total Claims: 126
Claim 1
Independent Claim
699 words
A device for delivering a beneficial drug at a controlled rate over a prolonged period, said device shaped, sized and adapted for delivering a drug to an animal environment of use, the device comprising: (A) an erodible released rate controlling polymer of the formula: ##STR6## wherein (I) R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkyloxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; wherein (II) R 2 and R 3 are selected from the grop consisting of alkyl of 1 to 7 carbons, alkenyl of 2 to 7 carbons, aryl or 6 to 12 carbons, an oxygen atom covalently bonded to the dioxycarbon atom, and when an oxygen atom R 2 and R 3 are a member selected from the group consisting of alkyloxy of 1 to 7 carbons; alkenyloxy of 2 to 7 carbons; and aryloxy of 6 to 12 carbons; and when only one of R 2 and R 3 is selected from said member the other R 2 and R 3 is selected from the group consisting of alkyl of 1 to 7 carbons; alkenyl of 2 to 7 carbons; and aryl of 6 to 12 carbons; wherein (III) R 2 and R 3 are intramolecularly covalently bonded to each other and to the same dioxycarbon atom, with at least one of R 2 and R 3 a ring oxygen atom forming a heterocyclic ring of 5 to 8 carbon and oxygen atoms when R 2 and R 3 are selected from the group consisting of alkylene of 2 to 6 carbons; alkenylene of 2 to 6 carbons; alkyleneoxy of 2 to 6 carbons; alkenyleneoxy of 2 to 6 carbons; alkylenedioxy of 2 to 5 carbons; alkenylenedieoxy of 2 to 5 carbons; oxa; and a heterocyclic ring of 5 to 8 carbon and oxygen atoms substituted with an alkyl of 1 to 7 carbons, an alkyloxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkenyloxy of 2 to 7 carbons; wherein (IV) R 2 and R 3 are intramolecularly covalently bonded to each other and to the same dioxycarbon atom with at least one of R 2 and R 3 is a ring oxygen atom forming a fused polycyclic ring of 8 to 12 carbon and oxygen atoms when R 2 and R 3 are a member selected from the group consisting of aralkylene of 8 to 12 carbons; aralkenylene of 8 to 12 carbons, aryloxy of 8 to 12 carbons; aralkyleneoxy of 8 to 12 carbons; aralkenyleneoxy of 8 to 12 carbons, aralkylenedioxy of 8 to 12 carbons; aralkenylenedioxy of 8 to 12 carbons; oxa; and a fused polycyclic ring of 8 to 12 carbon and oxygen atoms substituted with an alkyl of 1 to 7 carbons, an alkyloxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons and an alkenyloxy of 2 to 7 carbons; wherein (V) R 2 and R 3 are intramolecularly covalently bonded to each other and to the same dioxycarbon atom to form a 5 to 6 member carbocyclic ring; (B) a beneficial drug in the device; (C) an erosion rate modifier in the device in an amount that effects the period of time the device erodes and effects the amount of drug released as the device erodes over time; and wherein n is greater than 10.
Claim 2
Independent Claim
699 words
A device for delivering a beneficial drug at a controlled rate over a prolonged period, said device shaped, sized and adapted for delivering a drug to an animal environment of use, the device comprising: (A) an erodible released rate controlling polymer of the formula: ##STR6## wherein (I) R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkyloxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; wherein (II) R 2 and R 3 are selected from the grop consisting of alkyl of 1 to 7 carbons, alkenyl of 2 to 7 carbons, aryl or 6 to 12 carbons, an oxygen atom covalently bonded to the dioxycarbon atom, and when an oxygen atom R 2 and R 3 are a member selected from the group consisting of alkyloxy of 1 to 7 carbons; alkenyloxy of 2 to 7 carbons; and aryloxy of 6 to 12 carbons; and when only one of R 2 and R 3 is selected from said member the other R 2 and R 3 is selected from the group consisting of alkyl of 1 to 7 carbons; alkenyl of 2 to 7 carbons; and aryl of 6 to 12 carbons; wherein (III) R 2 and R 3 are intramolecularly covalently bonded to each other and to the same dioxycarbon atom, with at least one of R 2 and R 3 a ring oxygen atom forming a heterocyclic ring of 5 to 8 carbon and oxygen atoms when R 2 and R 3 are selected from the group consisting of alkylene of 2 to 6 carbons; alkenylene of 2 to 6 carbons; alkyleneoxy of 2 to 6 carbons; alkenyleneoxy of 2 to 6 carbons; alkylenedioxy of 2 to 5 carbons; alkenylenedieoxy of 2 to 5 carbons; oxa; and a heterocyclic ring of 5 to 8 carbon and oxygen atoms substituted with an alkyl of 1 to 7 carbons, an alkyloxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkenyloxy of 2 to 7 carbons; wherein (IV) R 2 and R 3 are intramolecularly covalently bonded to each other and to the same dioxycarbon atom with at least one of R 2 and R 3 is a ring oxygen atom forming a fused polycyclic ring of 8 to 12 carbon and oxygen atoms when R 2 and R 3 are a member selected from the group consisting of aralkylene of 8 to 12 carbons; aralkenylene of 8 to 12 carbons, aryloxy of 8 to 12 carbons; aralkyleneoxy of 8 to 12 carbons; aralkenyleneoxy of 8 to 12 carbons, aralkylenedioxy of 8 to 12 carbons; aralkenylenedioxy of 8 to 12 carbons; oxa; and a fused polycyclic ring of 8 to 12 carbon and oxygen atoms substituted with an alkyl of 1 to 7 carbons, an alkyloxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons and an alkenyloxy of 2 to 7 carbons; wherein (V) R 2 and R 3 are intramolecularly covalently bonded to each other and to the same dioxycarbon atom to form a 5 to 6 member carbocyclic ring; (B) a beneficial drug in the device; (C) an erosion rate modifier in the device in an amount that effects the period of time the device erodes and effects the amount of drug released as the device erodes over time; and wherein n is greater than 10.
Claim 3
Dependent Claim
33 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein erosion rate modifier decrease the rate of erosion of the polymer over time.
Claim 4
Dependent Claim
33 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier increase the rate of erosion of polymer over time.
Claim 5
Dependent Claim
45 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier controls the environment within the device by maintaining a relative pH of at least 7 when the device is in use.
Claim 6
Dependent Claim
45 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier controls the environment within the device by maintaining a relative pH of less than 7 when the device is in use.
Claim 7
Dependent Claim
58 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of metal oxides, salts of electronegative nonmetal oxides, hydrides, metals, hydroxides, amines, organic acids, inorganic acids, monobasic acid salts, polybasic acid salts, and hydroxides of nonmetals.
Claim 8
Dependent Claim
48 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of aluminum oxide, calcium oxide, lithium oxide, magnesium oxide, manganese oxide, potassium oxide, and sodium oxide.
Claim 9
Dependent Claim
84 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of calcium carbonate, lithium carbonate, magnesium carbonate, sodium acid carbonate, potassium carbonate, sodium carbonate, calcium phosphate, lithium phosphate, disodium hydrogen phosphate, magnesium phosphate, potassium dihydrogen phosphate, manganese phosphate, potassium phosphate, sodium phosphate, sodium hydrogen phosphate, calcium sulfite, lithium sulfite, magnesium sulfite, potassium sulfite, sodium sulfite, lithium sulfate, potassium sulfate, and sodium sulfate.
Claim 10
Dependent Claim
40 words
The device for delivering drug at a controlled rate over a prolonged period of tie according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of aluminum, calcium, lithium, magnesium, potassium, and sodium.
Claim 11
Dependent Claim
46 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of aluminum hydride, calcium hydride, lithium hydride, magnesium hydride, potassium hydride, and sodium hydride.
Claim 12
Dependent Claim
48 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of aluminum hydroxide, barium hydroxide, calcium hydroxide, lithium hydroxide, magnesium hydroxide, potassium hydroxide, and sodium hydroxide.
Claim 13
Dependent Claim
73 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of amygladic acid, adipic acid, boric acid, citric acid, fumaric acid, itaconic acid, lactic acid, malic acid, maleic acid, mesaconic acid, oxalic acid, phthalic acid, phosphoric acid, succinic acid, sulfamic acid, tartaric acid, glycine, amino acid, stannic chloride, and mixtures thereof.
Claim 14
Dependent Claim
44 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of trimethylamine, triethylamine, tridecylamine, hydroxylamine, propylamine, ethylenediamine, phenylcyclopropylamine, trihydroxytyriethylamine, 2,4,6-trimethylpyridine and 2-hydroxy-1-aminopropane.
Claim 15
Dependent Claim
62 words
The device for delivering drug at a controlled rate over a prolonged period of time according to claim 1 wherein the erosion rate modifier is a member selected from the group consisting of potassium tetraoxalate, potassium hydrogen tartrate, potassium hydrogen phthalate, sodium tetraoxalate, sodium hydrogen tartrate, sodium hydrogen phthalate, potassium dihydrogen citrate, sodium dihydrogen citrate, sodium acetate, sodium p-toluenesulfonate, and p-toluenesulfonic acid.
Claim 16
Independent Claim
317 words
A device for delivering a beneficial drug at a controlled rate over a prolonged period of time, which device is sized, shaped and adapted for delivering a drug to an animal, the device comprising (a) a polymer of the formula: ##STR7## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkyloxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons and an alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocycyclic ring selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxocanyl; dioxonanyl; tetrahydrofuranyl; dihydrofuranyl; furyl; pyranyl; ocanyl; and oxepanyl; (b) an erosion rate modifier dispersed in the device, said erosion rate modifier is a member selected from inorganic metals and compounds that decrease rate of erosion of the polymer, and inorganic metals and compounds that increase the rate of erosion of the polymer; (c) a dosage unit amount of a drug in the device, said drug a member selected from the group consisting of locally and systemically acting drugs; and wherein n is greater than 10.
Claim 17
Independent Claim
317 words
A device for delivering a beneficial drug at a controlled rate over a prolonged period of time, which device is sized, shaped and adapted for delivering a drug to an animal, the device comprising (a) a polymer of the formula: ##STR7## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkyloxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons and an alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocycyclic ring selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxocanyl; dioxonanyl; tetrahydrofuranyl; dihydrofuranyl; furyl; pyranyl; ocanyl; and oxepanyl; (b) an erosion rate modifier dispersed in the device, said erosion rate modifier is a member selected from inorganic metals and compounds that decrease rate of erosion of the polymer, and inorganic metals and compounds that increase the rate of erosion of the polymer; (c) a dosage unit amount of a drug in the device, said drug a member selected from the group consisting of locally and systemically acting drugs; and wherein n is greater than 10.
Claim 18
Dependent Claim
26 words
The device for delivering the beneficial drug over a period of time according to claim 15 wherein the device is sized and shaped as an implant.
Claim 19
Dependent Claim
26 words
The device for delivering the beneficial drug over a period of time according to claim 15 wherein the device is sizes and shaped as a strip.
Claim 20
Dependent Claim
22 words
The device for delivering the beneficial drug over a period of time according to claim 15 wherein the animal is a human.
Claim 21
Dependent Claim
26 words
The device for delivering the beneficial drug over a period of time according to claim 15 wherein the device is sized and shaped as a suppository.
Claim 22
Dependent Claim
23 words
The device for delivering the beneficial drug over a period of time according to claim 15 wherein the polymer is poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran).
Claim 23
Dependent Claim
22 words
The device for delivering the beneficial drug over a period of time according to claim 15 wherein the drug is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 24
Independent Claim
319 words
A device for delivering a beneficial drug at a controlled rate over a period of time, wherein the device is sized and shaped for delivering a drug to a warm-blooded animal, said device comprising (a) a polymer of the formula: ##STR8## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalet radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with ann alkyl of 1 to 7 carbons, alkyloxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; R 2 and R 3 are taken together defining a heterocyclic ring with at least one of R 2 and R 3 a ring forming oxygen atom, with the heterocyclic ring a member selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxocanyl; dioxonanyl; tetrahydrofuranyl; dihydrofuranyl; furyl; pyranyl; ocanyl; and oxepanyl; (b) an erosion rate modifier in the polymer, said erosion rate modifier selected from the group consisting of metals and inorganic compounds that decrease the rate of erosion of the polymer, and metals and inorganic compounds that increase the erosion rate of the polymer; (c) a drug in the polymer selected from the group consisting of hypoglycemic, and hormonal drugs; and n is greater than 10.
Claim 25
Independent Claim
319 words
A device for delivering a beneficial drug at a controlled rate over a period of time, wherein the device is sized and shaped for delivering a drug to a warm-blooded animal, said device comprising (a) a polymer of the formula: ##STR8## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalet radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with ann alkyl of 1 to 7 carbons, alkyloxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; R 2 and R 3 are taken together defining a heterocyclic ring with at least one of R 2 and R 3 a ring forming oxygen atom, with the heterocyclic ring a member selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxocanyl; dioxonanyl; tetrahydrofuranyl; dihydrofuranyl; furyl; pyranyl; ocanyl; and oxepanyl; (b) an erosion rate modifier in the polymer, said erosion rate modifier selected from the group consisting of metals and inorganic compounds that decrease the rate of erosion of the polymer, and metals and inorganic compounds that increase the erosion rate of the polymer; (c) a drug in the polymer selected from the group consisting of hypoglycemic, and hormonal drugs; and n is greater than 10.
Claim 26
Dependent Claim
81 words
The device for delivering the beneficial drug at a controlled rate over a period of time according to claim 20 wherein the polymer is defined by the following structural formula: ##STR9## wherein the hormone is a member selected from the group consisting of cortical, androgenic, estrogenic and progestational hormones; and wherein the erosion rate modifier is selected from the group consisting of metal oxides, salts of nonmetal oxides, hydrides, hydroxides, acids, monobasic, and polybasic salts, acidic salts, amines and mixtures thereof.
Claim 27
Dependent Claim
51 words
The device for delivering the beneficial drug at a controlled rate according to claim 23 wherein the hormone is a member selected from the group consisting of aldesterone, desoxycorticosterone, cortisone, hydrocortisone, prednisone, prednisolone, triamcinolone, paramethasone, dexamethasone, fludrocortisone acetate, flurandrenolone acetonide, betamethasone benzoate, dexamethasone phosphate, methyl prednisolone, prednisolone acetate, and triamcinolone acetonide.
Claim 28
Dependent Claim
67 words
The device for delivering the beneficial drug at a controlled rate according to claim 23 wherein the hormone is a member selected from the group consisting of estradiol, 17β-estradiol, 3-benzoate estradiol, 3-acetate estradiol, 17-acetate estradiol, 17β-propionate estradiol, 17β-heptanoate estradiol, 17β-undecanoate estradiol, 17β-valerate estradiol, 3-methyl ether estradiol, 3,17β-diacetate estradiol, 3,17β-dipropionate estradiol, hemisuccinate estradiol, 17β-cypionate estradiol, 17β-estradiol disodium diphosphate, estriol, estrone, ethinyl estradiol, estrazinol, estrofurate, quinestrol, and mixtures thereof.
Claim 29
Dependent Claim
63 words
The device for delivering the beneficial drug at a controlled rate according to claim 23 wherein the hormone is a member selected from the group consisting of progesterone, preganediol, algestone acetophenide, azacosterol, chlormadinone acetate, dyhdrogesterone, ethisterone, hydroxyprogesterone, medrogesterone, medroxyprogesterone, megestrol acetate, melengestrol acetate, allylestrenol, ethynodiol diacetate, lynestrenol, norethindrone, norethindrone acetate, norethynodrel, norgesterone, norgestrel, norgestrienone, norvinisterone, oxogestone, quingestrone, quingestanol acetate, tigestol, and mixtures thereof.
Claim 30
Dependent Claim
46 words
The device for delivering the beneficial drug at a controlled rate according to claim 23 wherein the hormone is a member selected from the group consisting of testosterone, testosterone propionate, methyl testosterone, mesterolone, fluoxymesterone, methandriol, methandrostenolone, methenolone enanthate, nandrolone, norethandrolone, oxymetholone, stanozolol, zeranol, and mixtures thereof.
Claim 31
Dependent Claim
55 words
The device for the delivery of the beneficial drug at a controlled rate according to claim 23 wherein the hypoglycemic drug is a member selected from the group consisting of insulin, zinc insulin, dalanated insulin, zinc globin insulin, isophane insulin, protamine insulin, extended zinc insulin, sulfonylureas, acetohexamide, glypinamide, chlorpropamide, tolazamide, tolbutamide, phenformin, and mixtures thereof.
Claim 32
Dependent Claim
47 words
The device for delivering the beneficial drug at a controlled rate according to claim 23 wherein the erosion rate modifier is a member selected from the group consisting of calcium oxide, calcium dibasic phosphate, calcium phosphate, magnesium carbonate, sodium carbonate, sodium bicarbonate, magnesium oxide, and mixtures thereof.
Claim 33
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 70% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 20% by weight of sodium carbonate, and 10% by weight of d-norethisterone.
Claim 34
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 70% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 20% by weight of sodium carbonate, and 10% by weight of d-norethisterone.
Claim 35
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 70% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% by weight of calcium oxide, and 20% by weight of norethindrone.
Claim 36
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 70% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% by weight of calcium oxide, and 20% by weight of norethindrone.
Claim 37
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 70% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5% by weight of calcium oxide, and 25% by weight of norethindrone.
Claim 38
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 70% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5% by weight of calcium oxide, and 25% by weight of norethindrone.
Claim 39
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 75% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5% by weight of calcium oxide, and 20% by weight of norethindrone.
Claim 40
Dependent Claim
25 words
A bioerodible, drug delivery implant comprising 75% by weight of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5% by weight of calcium oxide, and 20% by weight of norethindrone.
Claim 41
Dependent Claim
40 words
A bioerodible, drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5 to 30% of a member selected from the group consisting of sodium carbonate, calcium oxide, magnesium oxide and mixtures thereof, and 5 to 30% of norethindrone.
Claim 42
Dependent Claim
40 words
A bioerodible, drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5 to 30% of a member selected from the group consisting of sodium carbonate, calcium oxide, magnesium oxide and mixtures thereof, and 5 to 30% of norethindrone.
Claim 43
Dependent Claim
25 words
The bioerodible, drug delivery implant according to claim 33 wherein implant comprises 70% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of sodium carbonate, and 20% of norethindrone.
Claim 44
Dependent Claim
26 words
The bioerodible, drug delivery implant according to claim 33 wherein the implant comprises 70% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 20% of sodium carbonate, and 10% of norethindrone.
Claim 45
Dependent Claim
26 words
The bioerodible, drug delivery implant according to claim 33 wherein the implant comprises 55% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 20% of sodium carbonate, and 25% of norethindrone.
Claim 46
Dependent Claim
26 words
The bioerodible, drug delivery implant according to claim 33 wherein the implant comprises 50% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 20% of sodium carbonate, and 30% of norethindrone.
Claim 47
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 33 wherein the implant comprises 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5% of sodium carbonate, and 5% of norethindrone.
Claim 48
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 33 wherein the implant comprises 50% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 30% of sodium carbonate, and 20% of norethindrone.
Claim 49
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 33 wherein the implant comprises 70% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 20% of magnesium oxide and 10% of norethindrone.
Claim 50
Dependent Claim
25 words
The bioerodible drug delivery implant according to claim 33 wherein the implant comprises 60% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of magnesium oxide, and 30% norethindrone.
Claim 51
Dependent Claim
43 words
A bioerodible, drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5 to 30% of a member selected from the group consisting of sodium carbonate, sodium bicarbonate, magnesium oxide, lithium hydroxide and calcium hydride, and from 4 to 30% of norgestrel.
Claim 52
Dependent Claim
43 words
A bioerodible, drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5 to 30% of a member selected from the group consisting of sodium carbonate, sodium bicarbonate, magnesium oxide, lithium hydroxide and calcium hydride, and from 4 to 30% of norgestrel.
Claim 53
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 86% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of sodium carbonate, and 4% of norgestrel.
Claim 54
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 76.5% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 16.8% of sodium carbonate, and 6.7% of norgestrel.
Claim 55
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 76.4% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 16.8% of norgestrel and 6.8% of sodium carbonate.
Claim 56
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 76.5% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 16.8% of norgestrel, and 6.7% of magnesium oxide.
Claim 57
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 75% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 15% of norgestrel, and 10% of magnesium oxide.
Claim 58
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 75% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 15% of norgestrel and 10% of sodium carbonate.
Claim 59
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 71.1% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 15.6% of norgestrel, and 13.3% of sodium carbonate.
Claim 60
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 71.0% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 15.7% of norgestrel and 13.3% of magnesium oxide.
Claim 61
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 76.5% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 16.8% of norgestrel and 6.7% of sodium bicarbonate.
Claim 62
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 43 wherein the implant comprises 71.1% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 15.6% of norgestrel and 13.3% of sodium bicarbonate.
Claim 63
Dependent Claim
44 words
The bioerodible drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5 to 30% of a hypoglycemic drug, and 5 to 30% of a member selected from the group consisting of sodium carbonate, sodium bicarbonate, magnesium oxide, lithium hydroxide, and calcium hydride.
Claim 64
Dependent Claim
44 words
The bioerodible drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 5 to 30% of a hypoglycemic drug, and 5 to 30% of a member selected from the group consisting of sodium carbonate, sodium bicarbonate, magnesium oxide, lithium hydroxide, and calcium hydride.
Claim 65
Dependent Claim
42 words
A bioerodible drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), about 5 to 30% of insulin, and about 5 to 30% of an erosion rate modifier selected from the group consisting of sodium carbonate, sodium bicarbonate and magnesium oxide.
Claim 66
Dependent Claim
42 words
A bioerodible drug delivery implant comprising 50 to 90% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), about 5 to 30% of insulin, and about 5 to 30% of an erosion rate modifier selected from the group consisting of sodium carbonate, sodium bicarbonate and magnesium oxide.
Claim 67
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 55 wherein the implant comprises 80% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of insulin and 10% of sodium carbonate.
Claim 68
Dependent Claim
27 words
The bioerodible drug delivery implant according to claim 55 wherein the implant comprises about 80% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of sodium carbonate and 10% of insulin.
Claim 69
Dependent Claim
28 words
The bioerodible drug delivery implant according to claim 55 wherein the implant comprises about 75% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of sodium bicarbonate, and about 15% of insulin.
Claim 70
Dependent Claim
25 words
The bioerodible drug delivery implant according to claim 55 wherein the implant comprises 70% of poly(2,2dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), 10% of sodium carbonate, and 20% insulin.
Claim 71
Dependent Claim
29 words
The bioerodible drug delivery implant according to claim 55 wherein the implant comprises about 60% of poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), about 10% of magnesium oxide, and about 30% of insulin.
Claim 72
Dependent Claim
26 words
The bioerodible drug delivery implant according to claim 55 wherein the implant delivers 8 to 20 units of insulin per day for up to 14 days.
Claim 73
Dependent Claim
65 words
A topical device for delivering a drug to the skin and mucosa, the device comprising a backing member supporting on one surface thereof, a composition comprising poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), an erosion rate modifier selected from the group consisting of sodium carbonate, sodium bicarbonate and magnesium oxide, and a steroid selected from the group consisting of norgestrel, norethindrone, estradiol, ethinyl estradiol, mestranol, dimethisterone, and mixtures thereof.
Claim 74
Dependent Claim
65 words
A topical device for delivering a drug to the skin and mucosa, the device comprising a backing member supporting on one surface thereof, a composition comprising poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), an erosion rate modifier selected from the group consisting of sodium carbonate, sodium bicarbonate and magnesium oxide, and a steroid selected from the group consisting of norgestrel, norethindrone, estradiol, ethinyl estradiol, mestranol, dimethisterone, and mixtures thereof.
Claim 75
Dependent Claim
49 words
A topical device for delivering a drug to the skin and mucosa, the device comprising a backing member supporting on one surface thereof a composition comprising poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), nitroglycerin, lactose and an erosion rate modifier selected from the group consisting of sodium carbonate, sodium bicarbonate and magnesium oxide.
Claim 76
Dependent Claim
49 words
A topical device for delivering a drug to the skin and mucosa, the device comprising a backing member supporting on one surface thereof a composition comprising poly(2,2-dioxo-cis/trans-1,4-cyclohexane dimethylene tetrahydrofuran), nitroglycerin, lactose and an erosion rate modifier selected from the group consisting of sodium carbonate, sodium bicarbonate and magnesium oxide.
Claim 77
Dependent Claim
243 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR10## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons; alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxonanyl; tetrahydrofuranyl; dihydrofuranyl; furyl; pyranyl; ocanyl; and oxepanyl; and an erosion rate modifier for the polymer, said modifier a member selected from the group consisting of aluminum oxide, calcium oxide, lithium oxide, magnesium oxide, potassium oxide, and sodium oxide.
Claim 78
Dependent Claim
243 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR10## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons; alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxonanyl; tetrahydrofuranyl; dihydrofuranyl; furyl; pyranyl; ocanyl; and oxepanyl; and an erosion rate modifier for the polymer, said modifier a member selected from the group consisting of aluminum oxide, calcium oxide, lithium oxide, magnesium oxide, potassium oxide, and sodium oxide.
Claim 79
Dependent Claim
310 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR11## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom with the ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, pyranyl, ocanyl, and oxepanyl; an erosion rate modifier for the polymer, said modifier a member selected from the group consisting of calcium carbonate, lithium carbonate, magnesium carbonate, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium phosphate, lithium phosphate, magnesium phosphate, potassium phosphate, sodium phosphate, calcium sulfite, lithium sulfite, magnesium sulfite, potassium sulfite, sodium sulfite, lithium sulfate, potassium sulfate, and sodium sulfate; and a dosage unit amount of a beneficial drug that is released at a controlled rate as the bioerodible polymer bioerodes over time.
Claim 80
Dependent Claim
310 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR11## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom with the ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, pyranyl, ocanyl, and oxepanyl; an erosion rate modifier for the polymer, said modifier a member selected from the group consisting of calcium carbonate, lithium carbonate, magnesium carbonate, potassium carbonate, sodium carbonate, sodium bicarbonate, potassium bicarbonate, calcium phosphate, lithium phosphate, magnesium phosphate, potassium phosphate, sodium phosphate, calcium sulfite, lithium sulfite, magnesium sulfite, potassium sulfite, sodium sulfite, lithium sulfate, potassium sulfate, and sodium sulfate; and a dosage unit amount of a beneficial drug that is released at a controlled rate as the bioerodible polymer bioerodes over time.
Claim 81
Dependent Claim
301 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR12## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons and alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom, with the ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl, and oxepanyl; and n is greater than 10, and an erosion rate modifier selected from the group of acids consisting of amygladic, adipic, boric, citric, amino, fumaric, itaconic, latic, malic, maleic, mesaconic, oxalic, phthalic, phosphoric, succinic, sulfamic, and tartaric, which erosion rate modifier is present in an effective amount and cooperates with the polymer for regulating the rate of erosion of the polymer; and a dosage unit amount of drug for release in an effective amount over time.
Claim 82
Dependent Claim
301 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR12## wherein R 1 is a member selected from the group consisting of divalent, trivalent and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and an alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons and alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom, with the ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl, and oxepanyl; and n is greater than 10, and an erosion rate modifier selected from the group of acids consisting of amygladic, adipic, boric, citric, amino, fumaric, itaconic, latic, malic, maleic, mesaconic, oxalic, phthalic, phosphoric, succinic, sulfamic, and tartaric, which erosion rate modifier is present in an effective amount and cooperates with the polymer for regulating the rate of erosion of the polymer; and a dosage unit amount of drug for release in an effective amount over time.
Claim 83
Dependent Claim
287 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR13## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons. alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom, said ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl, and oxepanyl; and n is greater than 10; and an erosion rate modifier selected from the group consisting of potassium tetraoxalate, potassium hydrogen tartrate, potassium hydrogen phthalate, sodium tetraoxalate, sodium hydrogen tartrate, sodium hydrogen phthalate, a mixture of sodium tetraoxalate and sodium acid carbonate, a mixture of potassium dihydrogen phosphate and sodium hydrogen phosphate, potassium dihydrogen citrate, citric acid and sodium acetate, and glycine and citric acid.
Claim 84
Dependent Claim
287 words
A composition of matter comprising a bioerodible polymer of the general structure: ##STR13## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons. alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; cycloalkenylene of 4 to 7 carbons; cycloalkenylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, an alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom, said ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl, and oxepanyl; and n is greater than 10; and an erosion rate modifier selected from the group consisting of potassium tetraoxalate, potassium hydrogen tartrate, potassium hydrogen phthalate, sodium tetraoxalate, sodium hydrogen tartrate, sodium hydrogen phthalate, a mixture of sodium tetraoxalate and sodium acid carbonate, a mixture of potassium dihydrogen phosphate and sodium hydrogen phosphate, potassium dihydrogen citrate, citric acid and sodium acetate, and glycine and citric acid.
Claim 85
Independent Claim
248 words
A method for administering a contraceptive steroid to a warm-blooded animal, which method comprises: A. Admitting to the animal a bioerodible device, the device comprising: 1. a bioerodible polymer of the general structure: ##STR14## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; cycloalkylene of 4 to 7 carbons; cycloalkylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons. alkenyl of 2 to 7 carbons and alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom, said ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl, and oxepanyl; and n is greater than 10;
Claim 86
Independent Claim
248 words
A method for administering a contraceptive steroid to a warm-blooded animal, which method comprises: A. Admitting to the animal a bioerodible device, the device comprising: 1. a bioerodible polymer of the general structure: ##STR14## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; alkyleneoxy of 2 to 6 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; cycloalkylene of 4 to 7 carbons; cycloalkylene of 4 to 7 carbons substituted with an alkyl of 1 to 7 carbons, an alkoxy of 1 to 7 carbons, alkenyl of 2 to 7 carbons, and alkylene of 1 to 10 carbons; arylene of 6 to 12 carbons; arylene of 6 to 12 carbons substituted with an alkyl of 1 to 7 carbons, alkoxy of 1 to 7 carbons. alkenyl of 2 to 7 carbons and alkylene of 1 to 10 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring oxygen atom, said ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl, and oxepanyl; and n is greater than 10;
Claim 87
Dependent Claim
64 words
an effective amount of an erosion rate modifier that assists in regulating the rate of erosion of the polymer over time mixed with the polymer; 3. a dosage amount of a contraceptive steroid mixed with the polymer; and, B. administering a contraceptively effective amount of the steroid to the animal by the device bioeroding at a controlled rate over a prolonged period of time.
Claim 88
Dependent Claim
64 words
an effective amount of an erosion rate modifier that assists in regulating the rate of erosion of the polymer over time mixed with the polymer; 3. a dosage amount of a contraceptive steroid mixed with the polymer; and, B. administering a contraceptively effective amount of the steroid to the animal by the device bioeroding at a controlled rate over a prolonged period of time.
Claim 89
Dependent Claim
35 words
The method for administering the contraceptive steroid to the animal over time according to claim 68 wherein the steroid is a member selected from the group consisting essentially of testosterone, testosterone propionate and methyl testosterone.
Claim 90
Dependent Claim
36 words
A method for administering the contraceptive steroid to the animal over time according to claim 68 wherein the steroid is a member selected from the group consisting of androgenic, estrogenic and progestational steroids, and mixtures thereof.
Claim 91
Dependent Claim
42 words
The method for administering the contraceptive steroid to the animal over time according to claim 68 wherein the steroid is a member selected from the group consisting of ethinyl estradiol, mestranol, norethindrone, ethynodiol diacetate, norethynodrel, norethindrone acetate, norgestrel, progesterone, and mixtures thereof.
Claim 92
Dependent Claim
50 words
The method for administering the contraceptive steroid to the animal over time according to claim 68 wherein the polymer has the formula: ##STR15## wherein the erosion rate modifier is sodium carbonate, the steroid is norethindrone, the animal is a human, and the device is sized and shaped as an implant.
Claim 93
Dependent Claim
45 words
A method for administering the contraceptive steroid to the animal over time according to claim 68 wherein ##STR16## wherein the erosion rate modifier is magnesium oxide, the steroid is norethindrone, the animal is a human, and the device is sized and shaped as an implant.
Claim 94
Dependent Claim
50 words
The method for administering the contraceptive steroid to the animal over time according to claim 68 wherein the polymer has the formula: ##STR17## wherein the erosion rate modifier is sodium carbonate, the steroid is norgestrel, the animal is a human, and the device is sized and shaped as an implant.
Claim 95
Dependent Claim
50 words
The method for administering the contraceptive steroid to the animal over time according to claim 68 wherein the polymer has the formula: ##STR18## wherein the erosion rate modifier is magnesium oxide, the steroid is norgestrel, the animal is a human, and the device is sized and shaped as an implant.
Claim 96
Independent Claim
133 words
A method for administering a beneficially effective amount of a steroid to a warm-blooded animal, which method comprises: A. placing on the animal a bioerodible device, the device comprising: 1. A bioerodible polymer of the following structure: ##STR19## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; and alkyleneoxy of 2 to 6 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring forming oxygen atom, said ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl and oxepanyl, and n is greater than 10;
Claim 97
Independent Claim
133 words
A method for administering a beneficially effective amount of a steroid to a warm-blooded animal, which method comprises: A. placing on the animal a bioerodible device, the device comprising: 1. A bioerodible polymer of the following structure: ##STR19## wherein R 1 is a member selected from the group consisting of divalent, trivalent, and tetravalent radicals consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; and alkyleneoxy of 2 to 6 carbons; wherein R 2 and R 3 are taken together to form a 5 to 8 member heterocyclic ring with at least one of R 2 and R 3 a ring forming oxygen atom, said ring selected from the group consisting of dioxolanyl, dioxanyl, dioxepanyl, dioxonanyl, tetrahydrofuranyl, dihydrofuranyl, furyl, ocanyl and oxepanyl, and n is greater than 10;
Claim 98
Dependent Claim
74 words
an erosion rate modifier in an effective amount that assists in regulating the rate of erosion of the bioerodible polymer over time mixed with the polymer; 3. a steroid selected from the group consisting of cortical, androgenic, estrogenic, and progestational steroids, and mixtures thereof mixed with the polymer; and B. administering an effective amount of the steroid to the animal by the device bioeroding at a controlled rate over a prolonged period of time.
Claim 99
Dependent Claim
74 words
an erosion rate modifier in an effective amount that assists in regulating the rate of erosion of the bioerodible polymer over time mixed with the polymer; 3. a steroid selected from the group consisting of cortical, androgenic, estrogenic, and progestational steroids, and mixtures thereof mixed with the polymer; and B. administering an effective amount of the steroid to the animal by the device bioeroding at a controlled rate over a prolonged period of time.
Claim 100
Dependent Claim
52 words
The method for administering a beneficially effective amount of the steroid to the animal over time according to claim 76 wherein the androgenic steroid is a member selected from the group consisting of testosterone, testosterone propionate, methyl testosterone, mesterolone, fluoxymesterone, methandriol, methandrostenolone, methenolone enanthate, nadrolone, morethandrolone, oxymetholone, stanozolol, zeranol, and mixtures thereof.
Claim 101
Dependent Claim
33 words
The method for administering a beneficially effective amount of the steroid to the animal over time according to claim 76 wherein the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran) and the steroid is an androgenic steroid.
Claim 102
Dependent Claim
33 words
The method for administering a beneficially effective amount of the steroid to the animal over time according to claim 76 wherein the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran) and the steroid is an estrogenic steroid.
Claim 103
Dependent Claim
33 words
The method for administering a beneficially effective amount of the steroid to the animal over time according to claim 76 wherein the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran) and the steroid is a progestational steroid.
Claim 104
Dependent Claim
55 words
The method for administering a therapeutically effective amount of the steroid to the animal over time according to claim 76, wherein the cortical steroid is a member from the group consisting of aldosterone, desoxycorticosterone, cortisone, hydrocortisone, prednisone, prednisolone, triamcinolone, paramethasone, dexamethasone, fludrocortisone, flurandrenolone acetonide, betamethasone, benzoate, dexamethasone phosphate, methyl prednisolone, prednisolone acetate, and triamcinolone acetonide.
Claim 105
Dependent Claim
84 words
The method for administering a beneficially effective amount of the steroid to the animal over time according to claim 76 wherein the estrogenic steroid is a member selected from the group consisting of estradiol, 3-benzoate estradiol, 3-acetate estradiol, 17β-acetate estradiol, 17β-propionate estradiol, 17β-heptanoate estradiol, 17β-undecanoate estradiol, 17β-valerate estradiol, 3-methyl ether estradiol, 3,17β-diacetate estradiol, 3,17β-dipropionate estradiol, hemisuccinate estradiol, estradiol 17 β-cypionate, 17 β-estradiol disodium diphosphate, 17 β-estradiol disodium sulfate, 17 β-estradiol-3(disodium phosphate), 17 β-estradiol-17-(disodium phosphate), estriol, estrone, ethinyl, estradiol, estrazinol, estrofurate, guinestrol, and mixtures thereof.
Claim 106
Dependent Claim
69 words
The method for administering a beneficially effective amount of the steroid to the animal over time according to claim 76 wherein the progestational steroid is a member selected from the group consisting of progesterone, preganediol, algestone, acetophenide, azacosterol, chlormadinone acetate, dyhydrogesterone, ethisterone, hydroxyprogesterone, medrogestone, medroxyprogesterone, megestrol acetate, melengestrol acetate, allylestrenol, ethynodiol, diacetate, lynestrenol, norethindrone, norethindrone acetate, norethynodrel, norgesterone, norgestrel, norgestrienone, norvinisterone, oxogestone, quingestrone, quingestanol acetate, tigestol, and mixtures thereof.
Claim 107
Dependent Claim
35 words
The method for administering a beneficially effective amount of steroid to the animal according to claim 76 wherein the device is sized and shaped for placing topically on the skin and mucosa of the animal.
Claim 108
Dependent Claim
44 words
The method for adminstering a beneficially effective amount of the steroid to the animal according to claim 76 wherein the device is manufactured as a topical device comprising a backing member with the bioerodible polymer, the modified and the steroid on one surface thereof.
Claim 109
Independent Claim
158 words
A device for delivering a beneficial drug at a controlled rate over a prolonged period of time, when the device is sized, shaped and adapted for delivering a drug to a drug receptor site, said device comprising (a) a polymer of the formula: ##STR20## wherein R 1 is a member selected from the group consisting of alkylene of 1 to 10 carbons and alkenylene of 2 to 10 carbons; R 2 and R 3 are taken together forming a heterocyclic ring selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxocanyl; dioxonanyl; furyl, tetrahydrofruanyl; dihydrofuranyl; pyranyl; ocanyl; and oxepanyl; a nontoxic erosion rate modifier admixed with the polymer in an effective amount that cooperates with the polymer for regulating the rate of erosion of the polymer over time; a drug admixed with the polymer and the erosion rate modifier, which drug is released from the device to produce a beneficial therapeutic effect; and n is greater than 10.
Claim 110
Independent Claim
158 words
A device for delivering a beneficial drug at a controlled rate over a prolonged period of time, when the device is sized, shaped and adapted for delivering a drug to a drug receptor site, said device comprising (a) a polymer of the formula: ##STR20## wherein R 1 is a member selected from the group consisting of alkylene of 1 to 10 carbons and alkenylene of 2 to 10 carbons; R 2 and R 3 are taken together forming a heterocyclic ring selected from the group consisting of dioxolanyl; dioxanyl; dioxepanyl; dioxocanyl; dioxonanyl; furyl, tetrahydrofruanyl; dihydrofuranyl; pyranyl; ocanyl; and oxepanyl; a nontoxic erosion rate modifier admixed with the polymer in an effective amount that cooperates with the polymer for regulating the rate of erosion of the polymer over time; a drug admixed with the polymer and the erosion rate modifier, which drug is released from the device to produce a beneficial therapeutic effect; and n is greater than 10.
Claim 111
Dependent Claim
65 words
The device for delivering a beneficial drug according to claim 86 wherein the drug is a member selected from the group consisting of local and systemic drugs, the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran), and the erosion rate modifier is a member selected from the group consisting of a metal oxide, a salt of a nonmetal oxide, hydride, hydroxide, monobasic and polybasic acids, amines, and mixtures thereof.
Claim 112
Dependent Claim
39 words
The device for the delivery of a beneficial drug according to claim 86, wherein the drug is a member selected from the group consisting of cortical, androgenic, estrogenic and progestational steroids, and wherein the polymer is poly (2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 113
Dependent Claim
60 words
The device for the controlled delivery of the beneficial drug according to claim 86 wherein the steroid is a member selected from the group of crotical hormones consisting of aldesterone, desoxycorticosterone, cortisone, hydrocortisone, prednisone, prednisolone, triamcinolone, paramethasone, dexamethasone, fludrocortisone acetate, flurandrenolone acetonide, betamethasone benzoate, dexamethasone phosphate, methyl prednisolone, prednisolone acetate, and triamcinolone acetonide, and wherein the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 114
Dependent Claim
71 words
The device for the controlled delivery of the beneficial drug according to claim 86 wherein the steroid is an estrogenic hormone selected from the group consisting of estradiol, 17β-estradiol, 3-benzoate estradiol, 3-acetate estradiol; 17β-acetate estradiol, 17β-propionate estradiol, 17β-heptanoate estradiol, 17β-undecanoate estradiol, 17β-valerate estradiol, 3-methyl ether estradiol, 3,17β-diacetate estradiol, 3,17β-dipropionate estradiol, hemisuccinate estradiol, 17β-cypionate estradiol, 17β-estradiol disodium diphosphate, estriol, estrone, ethinyl estradiol, estrazinol, estrofurate, guinestrol, and wherein the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 115
Dependent Claim
74 words
The device for the controlled delivery of the beneficial drug according to claim 86 wherein the device contains a dosage unit amount of a steroid selected from the group of progestational hormones consisting of progesterone, preganediol, algestone acetophenide, azacosterol, chlormadinone acetate, dyhydrogesterone, ethisterone, hydroxyprogesterone, medrogestone, medroxyprogesterone, megestrol acetate, melengestrol acetate, allylestrenol, ethynodiol diacetate, lynestrenol, norethindrone, norethindrone acetate, norethynodrel, norgesterone, norgestrel, norgestrienone, norvinesterone, oxogestone, quingestrone, quingestranol acetate, and tigestol, and the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 116
Dependent Claim
56 words
The device for the controlled delivery of the beneficial drug according to claim 86 wherein the device administers a therapeutically effective amount of a steroid selected from the group of androgens consisting of testosterone, testosterone propionate, methyl testosterone, mesterolone, fluoxymesterone, methandriol, methandrostenolone, methenolone enanthate, nandrolone, norethandrolone, oxymetholone, stanozolol, and zeranol, and the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 117
Dependent Claim
54 words
The device for the controlled delivery of the beneficial drug according to claim 86 wherein the device administers a therapeutically effective amount of a smooth muscle relaxant selected from the group consisting of amyl nitrate, glyceryl trinitrate, octyl nitrate, clonitrate, erythrityl tetranitrate, isosorbide dinitrate, mannitol hexanitrate and pentaerythritol, and the polymer is poly(2,2-dioxo-1,6-hexamethylene tetrahydrofuran).
Claim 118
Dependent Claim
82 words
A bioerodible ocular composition adapted for easy placement in an ocular environment, said composition comprising poly(2,2-dioxo-cyclohexane-dimethylene tetrahydrofuran), a dosage amount of a member selected from the group consisting of locally and systemically acting drugs administrable to the ocular environment, and a pharmaceutically acceptable bioerosion rate modifier in an effective amount that aids in controlling the rate of bioerosion of the composition in the ocular environment over time, whereby a therapeutically effective amount of drug is administered to the ocular environment over time.
Claim 119
Dependent Claim
82 words
A bioerodible ocular composition adapted for easy placement in an ocular environment, said composition comprising poly(2,2-dioxo-cyclohexane-dimethylene tetrahydrofuran), a dosage amount of a member selected from the group consisting of locally and systemically acting drugs administrable to the ocular environment, and a pharmaceutically acceptable bioerosion rate modifier in an effective amount that aids in controlling the rate of bioerosion of the composition in the ocular environment over time, whereby a therapeutically effective amount of drug is administered to the ocular environment over time.
Claim 120
Dependent Claim
47 words
The bioerodible ocular composition adapted for easy placement in an ocular environment according to claim 94, wherein the polymer has a cis/trans-1,4 cyclohexane isomeric configuration and the composition is manufactured as an ocular insert sized and shaped for easy placement and comfortable retention in the ocular environment.
Claim 121
Dependent Claim
40 words
The bioerodible ocular composition adapted for easy placement in the ocular environment according to claim 94, wherein the polymer comprises a cis/trans-1,4-cyclohexane isomeric structure, the composition is manufactured as an ocular insert, and the drug is a pharmaceutically acceptable antibiotic.
Claim 122
Dependent Claim
40 words
The bioerodible ocular composition adapted for easy placement in the ocular environment according to claim 94, wherein the polymer comprises a cis/trans-1,4-cyclohexane isomeric structure, the composition is manufactured as an ocular insert, and the drug is a pharmaceutically acceptable steroid.
Claim 123
Dependent Claim
90 words
A bioerodible ocular composition adapted for easy placement in an ocular environment of use, said composition comprising poly(2,2-dioxo-1,6 hexamethylene tetrahydrofuran), a dosage amount of a member selected from the group consisting of locally and systemically acting drugs administrable to the ocular environment in a therapeutically effective amount, and a pharmaceutically acceptable bioerosion rate modifier in an effective amount that aids in controlling the rate of bioerosion of the composition in the ocular environment over time, whereby a therapeutically effective amount of drug is administered to the ocular environment over time.
Claim 124
Dependent Claim
90 words
A bioerodible ocular composition adapted for easy placement in an ocular environment of use, said composition comprising poly(2,2-dioxo-1,6 hexamethylene tetrahydrofuran), a dosage amount of a member selected from the group consisting of locally and systemically acting drugs administrable to the ocular environment in a therapeutically effective amount, and a pharmaceutically acceptable bioerosion rate modifier in an effective amount that aids in controlling the rate of bioerosion of the composition in the ocular environment over time, whereby a therapeutically effective amount of drug is administered to the ocular environment over time.
Claim 125
Dependent Claim
24 words
The bioerodible ocular composition adapted for easy placement in the ocular environment according to claim 98 wherein the drug is a pharmaceutically acceptable antibiotic.
Claim 126
Dependent Claim
24 words
The bioerodible ocular composition adapted for easy placement in the ocular environment according to claim 98 wherein the drug is a pharmaceutically acceptable steroid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-30 | 1986-03-01 | 1986-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-30 | 1990-03-01 | 1990-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-30 | 1994-03-01 | 1994-08-31 | $7700.00 | Window Closed / Lapsed |