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US4070347A
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Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality
Assignee: Alza Corp
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Filing: 1976-08-16
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Granted: 1978-01-24
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Expires: 1996-08-16
Abstract
Abstract Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers comprising (1) a repeating dioxycarbon unit in the polymeric backbone having a plurality of organic groups pendant therefrom, and (2) a bridging moiety having at least one carbonyloxy group contained therein are disclosed. The polymers are represented by the formula: ##STR1## wherein R is a bridging moiety and is either R 1 or R 2 arranged in a random manner along the polymeric backbone to form a copolymer containing both R 1 and R 2 with R 1 an aliphatic, an alicyclic or an aromatic group and R 2 is a ##STR2## GROUP WITH R 1 as defined and R 3 an aliphatic, an alicyclic or aromatic group, or wherein R is a bridging moiety and is only R 2 to form a homopolymer with R 1 , R 2 and R 3 as defined above, and a is 0 to 1, b is 2 to 6, and n and the sum of x and y are positive integers. The copolymers are useful for making articles of manufacture, including devices and coatings for delivering beneficial agents.
Inventors
- 👤 Edward Emil Schmitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:24
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/34; A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; C05; C05G; C05G5/00; C05G5/30; C05G5/37
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
404 words
A polymer of the general formula: ##STR33## wherein R is a member selected from the group consisting of (1) R 1 and R 2 randomly arranged on the polymeric backbone to form a polymer containing both R 1 and R 2 , and (2) R 2 only, with R 1 selected from the group consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; cycloalkenylene of 5 to 7 carbons; cycloalkenylene of 5 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons; alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; arylene; arylene of 6 to 20 carbons substituted with an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons, and alkylene of 1 to 10 carbons; and with R 2 a ##STR34## group with R 1 as defined and R 3 independently selected from the group consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; cycloalkenylene of 5 to 7 carbons; cycloalkenylene of 5 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; arylene; arylene of 6 to 20 carbons substituted with an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; and a is 0 to 1, b is 2 to 6, x and y are independently 0 to 100 with the proviso that at least one of x and y is at least one, and n is at least 10.
Claim 2
Dependent Claim
404 words
A polymer of the general formula: ##STR33## wherein R is a member selected from the group consisting of (1) R 1 and R 2 randomly arranged on the polymeric backbone to form a polymer containing both R 1 and R 2 , and (2) R 2 only, with R 1 selected from the group consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; cycloalkenylene of 5 to 7 carbons; cycloalkenylene of 5 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons; alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; arylene; arylene of 6 to 20 carbons substituted with an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons, and alkylene of 1 to 10 carbons; and with R 2 a ##STR34## group with R 1 as defined and R 3 independently selected from the group consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons; cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; cycloalkenylene of 5 to 7 carbons; cycloalkenylene of 5 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; arylene; arylene of 6 to 20 carbons substituted with an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; and a is 0 to 1, b is 2 to 6, x and y are independently 0 to 100 with the proviso that at least one of x and y is at least one, and n is at least 10.
Claim 3
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR35##
Claim 4
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR36##
Claim 5
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR37##
Claim 6
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR38##
Claim 7
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR39##
Claim 8
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR40##
Claim 9
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR41##
Claim 10
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR42##
Claim 11
Dependent Claim
18 words
A copolymer according to claim 1 of the formula wherein m and n are 10 to 1000: ##STR43##
Claim 12
Dependent Claim
210 words
A homopolymer of the general formula: ##STR44## wherein R 1 is a member selected from the group consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons, cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; cycloalkenylene of 5 to 7 carbons; cycloalkenylene of 5 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; arylene; arylene of 6 to 20 carbons substituted with an alkyl of 1 to 10 carbons; alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; and wherein R 3 is the same as R 1 , a is 0 to 1, b is 2 to 6, n is 10 to 1000 and x and y are 0 to 100 with the proviso that one of x and y is always at least one.
Claim 13
Dependent Claim
210 words
A homopolymer of the general formula: ##STR44## wherein R 1 is a member selected from the group consisting of alkylene of 1 to 10 carbons; alkenylene of 2 to 10 carbons, cycloalkylene of 3 to 7 carbons; cycloalkylene of 3 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; cycloalkenylene of 5 to 7 carbons; cycloalkenylene of 5 to 7 carbons substituted with a member selected from the group consisting of an alkyl of 1 to 10 carbons, alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; arylene; arylene of 6 to 20 carbons substituted with an alkyl of 1 to 10 carbons; alkenyl of 2 to 10 carbons, alkoxy of 1 to 10 carbons and alkylene of 1 to 10 carbons; and wherein R 3 is the same as R 1 , a is 0 to 1, b is 2 to 6, n is 10 to 1000 and x and y are 0 to 100 with the proviso that one of x and y is always at least one.
Claim 14
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR45##
Claim 15
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR46##
Claim 16
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR47##
Claim 17
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR48##
Claim 18
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR49##
Claim 19
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR50##
Claim 20
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR51##
Claim 21
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR52##
Claim 22
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR53##
Claim 23
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR54##
Claim 24
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR55##
Claim 25
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR56##
Claim 26
Dependent Claim
17 words
A homopolymer according to claim 11 of the formula wherein x and y are least one: ##STR57##
Claim 27
Dependent Claim
18 words
A homopolymer accordng to claim 11 of the formula wherein x and y are at least one: ##STR58##
Claim 28
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR59##
Claim 29
Dependent Claim
21 words
A homopolymer according to claim 11 of the formula wherein the sum of x and y are at least one: ##STR60##
Claim 30
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR61##
Claim 31
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR62##
Claim 32
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR63##
Claim 33
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR64##
Claim 34
Dependent Claim
18 words
A homopolymer according to claim 11 of the formula wherein x and y are at least one: ##STR65##
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-23 | 1981-07-25 | 1982-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-23 | 1985-07-25 | 1986-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-23 | 1989-07-25 | 1990-01-24 | $7700.00 | Window Closed / Lapsed |