Patent US5670169A successfully refreshed from Google Patents.
US5670169A
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Wound hydrating gel with novel preservative system and low cytotoxicity
Assignee: Convatec Technologies Inc
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Filing: 1993-12-20
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Granted: 1997-09-23
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Expires: 2013-12-20
Abstract
Abstract The present invention relates to a preserved, yet non-cytotoxic alginate based hydrating gel system for the purpose of treating wounds that need moisture. Sodium carboxymethylcellulose and an alginate polymer blend impart sufficient viscosity to an aqueous solution to provide moisture to the wound. The blend reduces the cytotoxicity of a combination of preservatives incorporated into the system. More specifically, the invention relates to a wound hydrating gel comprising a) a hydrocolloid mixture of carboxymethylcellulose and sodium/calcium alginate, and b) a preservative system. This invention further relates to methods of preparing and using the wound hydrating gel.
Inventors
- 👤 Marc D. Cornell
- 👤 Nancy E. Kaiser
- 👤 Rita A. Brenden
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:09
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K9/00; A61K9/0012; A61K9/0014; A61L; A61L26/00; A61L26/0009; A61L26/0052; Y; Y10; Y10S; Y10S524/00; Y10S524/916
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
35 words
A non-cytotoxic wound hydrating gel consisting essentially of: a. a hydrocolloid system of sodium/calcium alginate and sodium carboxymethylcellulose, and b. a preservative system of dimethylol dimethylhydantoin, an antimicrobial agent and a mold and yeast inhibitor.
Claim 2
Dependent Claim
35 words
A non-cytotoxic wound hydrating gel consisting essentially of: a. a hydrocolloid system of sodium/calcium alginate and sodium carboxymethylcellulose, and b. a preservative system of dimethylol dimethylhydantoin, an antimicrobial agent and a mold and yeast inhibitor.
Claim 3
Dependent Claim
31 words
The non-cytotoxic wound hydrating gel of claim 1 wherein the sodium/calcium alginate is selected from the group consisting of sodium/calcium alginates having about 6-7% sodium minerals and about 2.5-3.5% calcium minerals.
Claim 4
Dependent Claim
34 words
The non-cytotoxic wound hydrating gel of claim 1 wherein sodium carboxymethylcellulose is present in an amount of about 0.1-1.0 wt. %, and sodium/calcium alginate is present in an amount of about 0.2-2.00 wt. %.
Claim 5
Dependent Claim
34 words
The non-cytotoxic wound hydrating gel of claim 3 wherein sodium carboxymethylcellulose is present in an amount of about 0.2-0.8 wt. %, and sodium/calcium alginate is present in an amount of about 0.5-1.5 wt. %.
Claim 6
Dependent Claim
34 words
The non-cytotoxic wound hydrating gel of claim 4 wherein sodium carboxymethylcellulose is present in an amount of about 0.6 wt. %, and sodium/calcium alginate is present in an amount of about 1.5 wt. %.
Claim 7
Dependent Claim
26 words
The non-cytotoxic wound hydrating gel of claim 1 wherein: a. the antimicrobial agent is boric acid, and b. the mold and yeast inhibitor is potassium sorbate.
Claim 8
Dependent Claim
40 words
The non-cytotoxic wound hydrating gel of claim 6 wherein the relative weight percentages of the non-water components are: ______________________________________
Sodium/Calcium Alginate
about 1.5%
Dimethylol Dimethylhydantoin
about 0.1%
Potassium Sorbate about 0.2%
Boric Acid about 0.5%
Sodium Carboxymethylcellulose
about 0.6%.
______________________________________
Claim 9
Dependent Claim
85 words
A process for preparing the non-cytotoxic wound hydrating gel of claim 1 comprising the steps of: a. dissolving, with agitation, all components of the preservative system in deionized water to form a solution and thereafter maintaining the agitation so that a vortex is present; b. adding sodium carboxymethylcellulose to the edge of the vortex and allowing the solution to mix for 60-90 minutes; c. adding sodium/calcium alginate powder into the vortex of the solution; and d. mixing the solution until a uniform product is obtained.
Claim 10
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 1.
Claim 11
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 2.
Claim 12
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 3.
Claim 13
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 4.
Claim 14
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 5.
Claim 15
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 6.
Claim 16
Dependent Claim
32 words
A method of providing a moist wound environment to facilitate the healing process of a wound comprising the step of applying directly to the wound a non-cytotoxic hydrating gel of claim 7.
Claim 17
Dependent Claim
40 words
The non-cytotoxic wound hydrating gel of claim 6 wherein the relative weight percentages of the non-water components are: ______________________________________
Sodium/Calcium Alginate
about 0.2%
Dimethylol Dimethylhydantoin
about 0.1%
Potassium Sorbate about 0.2%
Boric Acid about 0.5%
Sodium Carboxymethylcellulose
about 0.04%.
______________________________________
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-22 | 2001-03-24 | 2001-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-22 | 2005-03-24 | 2005-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-22 | 2009-03-24 | 2009-09-23 | $7700.00 | Window Closed / Lapsed |