US4470814A
Expired / Lapsed
US
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Method of adhering dentures
Assignee: Block Drug Co Inc
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Filing: 1983-09-02
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Granted: 1984-09-11
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Expires: 2003-09-02
Abstract
Abstract A method for adhering dentures to oral mucosa with a denture fixative composition containing as the active fixative a partially neutralized and crosslinked polyacrylic acid or a precursor combination of the polyacrylic acid, neutralizing agent(s) and crosslinking agent(s) which is adapted to form the active fixative, and at least one hydrophilic polymer, preferably, sodium carboxymethyl cellulose, hydroxypropyl guar or sodium alginate.
Inventors
- 👤 Tiang-Shing Chang
- 👤 Lucy J. Zientek
- 👤 Arthur Viningauz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:24
CPC Classifications
A; A61; A61K; A61K6/00; A61K6/30; A61K6/35
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
186 words
In a method of adhering dentures to oral mucosa employing a denture fixative which spreads over the denture-mucosa interface to fill the gaps therebetween, the improvement which comprises employing, as the denture fixative, a composition comprising a dentally acceptable excipient and an effective denture fixative amount of a combination of (a) polyacrylic acid which has been partially neutralized by at least one monovalent cation and partially neutralized by at least one monovalent cation and partially crosslinked by at least one agent selected from the group consisting of the salts, bases and oxides of divalent cations and polyhydroxy compounds such that 20-90% of the initial carboxyl groups have been neutralized or crosslinked, wherein a 1% aqueous solution of said partially neutralized and crosslinked polyacrylic acid has a pH of at least about 4.5, or a precursor combination of polyacrylic acid, neutralizing agent and crosslinking agent or of partially neutralized polyacrylic acid and crosslinking agent or of partially crosslinked polyacrylic acid and neutralizing agent, said precursor combination adapted to form said partially neutralized and crosslinked polyacrylic acid in an aqueous environment, and (b) at least one hydrophilic polymer.
Claim 2
Dependent Claim
186 words
In a method of adhering dentures to oral mucosa employing a denture fixative which spreads over the denture-mucosa interface to fill the gaps therebetween, the improvement which comprises employing, as the denture fixative, a composition comprising a dentally acceptable excipient and an effective denture fixative amount of a combination of (a) polyacrylic acid which has been partially neutralized by at least one monovalent cation and partially neutralized by at least one monovalent cation and partially crosslinked by at least one agent selected from the group consisting of the salts, bases and oxides of divalent cations and polyhydroxy compounds such that 20-90% of the initial carboxyl groups have been neutralized or crosslinked, wherein a 1% aqueous solution of said partially neutralized and crosslinked polyacrylic acid has a pH of at least about 4.5, or a precursor combination of polyacrylic acid, neutralizing agent and crosslinking agent or of partially neutralized polyacrylic acid and crosslinking agent or of partially crosslinked polyacrylic acid and neutralizing agent, said precursor combination adapted to form said partially neutralized and crosslinked polyacrylic acid in an aqueous environment, and (b) at least one hydrophilic polymer.
Claim 3
Dependent Claim
43 words
The method of adhering dentures of claim 1 wherein said polyacrylic acid has an average molecular weight of about 2,000,000-4,000,000, said monovalent cation is sodium or potassium, said divalent cation is magnesium or calcium and said polyhydroxy compound is glycerin or propylene glycol.
Claim 4
Dependent Claim
42 words
The method of adhering dentures of claim 2 where the amount of neutralizing agent is sufficient to neutralize about 10-70% of the initial carboxyl groups and the amount of crosslinking agent is sufficient to crosslink about 10-80% of the initial carboxyl groups.
Claim 5
Dependent Claim
27 words
The method of adhering dentures of claim 3 wherein a 1% aqueous solution of said partially neutralized and crosslinked polyacrylic acid has a pH of about 5.0-7.0.
Claim 6
Dependent Claim
15 words
The method of adhering dentures of claim 4 wherein said fixative is said precursor combination.
Claim 7
Dependent Claim
20 words
The method of adhering dentures of claim 5 wherein the precursor combination comprises partially neutralized polyacrylic acid and crosslinking agent.
Claim 8
Dependent Claim
58 words
The method of adhering dentures of claim 1 wherein said polyacrylic acid has an average molecular weight of about 500,000-5,000,000, said divalent cation is an alkaline earth metal cation, said polyhydroxy compound has 2 to 6 carbon atoms and said monovalent cation is an alkali metal cation, and wherein said hydrophilic polymer is a natural or synthetic gum.
Claim 9
Dependent Claim
39 words
The method of adhering dentures of claim 3 wherein the ratio of monovalent cation to divalent cation is about 1:4-4:1 and the amount of polyhydroxy compound is sufficient to react with up to 30% of the initial carboxyl groups.
Claim 10
Dependent Claim
18 words
The method of adhering dentures of claim 3 wherein said fixative is about 10-70 wt.% of said composition.
Claim 11
Dependent Claim
20 words
The method of adhering dentures of claim 7 wherein said hydrophilic polymer is carboxymethyl cellulose, hydroxpropyl guar or sodium alginate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-09-11 | 1988-03-12 | 1988-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-09-11 | 1992-03-12 | 1992-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-09-11 | 1996-03-12 | 1996-09-11 | $7700.00 | Window Closed / Lapsed |