US5192802A
Expired / Lapsed
US
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Bioadhesive pharmaceutical carrier
Assignee: Kenvue Brands LLC
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Filing: 1991-09-25
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Granted: 1993-03-09
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Expires: 2011-09-25
Abstract
Abstract Bioadhesive pharmaceutical carrier consisting essentially of a polymer blend of sodium carboxymethyl cellulose and xanthan gum or sodium alginate. The invention also provides for a method of control releasing a pharmaceutical active comprising incorporating an active into the bioadhesive pharmaceutical carrier. The invention is particularly adaptable for oral use and teething gels.
Inventors
- 👤 William F. Rencher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006; A61K9/0063; Y; Y10; Y10S; Y10S424/00; Y10S424/14; Y10S424/15
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
98 words
A teething gel consisting essentially from about 5 to 10% benzocaine; 5 to 20% NaCMC; an agent selected from the group consisting of 5 to 20% xanthan gum and 10 to 20% sodium alginate and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweetener and mixtures thereof.
Claim 2
Dependent Claim
98 words
A teething gel consisting essentially from about 5 to 10% benzocaine; 5 to 20% NaCMC; an agent selected from the group consisting of 5 to 20% xanthan gum and 10 to 20% sodium alginate and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweetener and mixtures thereof.
Claim 3
Dependent Claim
79 words
A teething gel consisting essentially of from about 5 to 10% benzocaine; 5 to 15% glycerine; 5 to 20% NaCMC; 5 to 20% xanthan gum; and 35 to 75% polyethylene glycol wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 4
Dependent Claim
79 words
A teething gel consisting essentially of from about 5 to 10% benzocaine; 5 to 15% glycerine; 5 to 20% NaCMC; 5 to 20% xanthan gum; and 35 to 75% polyethylene glycol wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 5
Dependent Claim
84 words
A teething gel consisting essentially from about 5 to 10% benzocaine; 5 to 20% NaCMC; 10 to 20% sodium alginate; and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings flavors, sweetener and mixtures thereof.
Claim 6
Dependent Claim
84 words
A teething gel consisting essentially from about 5 to 10% benzocaine; 5 to 20% NaCMC; 10 to 20% sodium alginate; and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings flavors, sweetener and mixtures thereof.
Claim 7
Dependent Claim
19 words
The teething gel of claim 3 wherein the benzocaine is present in an amount of about 7.5% by weight.
Claim 8
Dependent Claim
19 words
The teething gel of claim 3 wherein the glycerine is present in an amount of about 10% by weight.
Claim 9
Dependent Claim
16 words
The teething gel of claim 3 wherein additional present are pharmaceutically acceptable flavorings and antimicrobial preservatives.
Claim 10
Dependent Claim
41 words
The teething gel of claim 3 wherein the polyethylene glycol is a mixture of about 30% to 60% polyethylene glycol with an average molecular weight of 600 and about 5 to 15% polyethylene glycol with an average molecular weight of 3350.
Claim 11
Dependent Claim
19 words
The teething gel of claim 1 wherein the benzocaine is present in an amount of about 7.5% by weight.
Claim 12
Dependent Claim
19 words
The teething gel of claim 2 wherein the glycerine is present in an amount of about 10% by weight.
Claim 13
Dependent Claim
16 words
The teething gel of claim 2 wherein additionally present are pharmaceutically acceptable flavorings and antimicrobial preservatives.
Claim 14
Dependent Claim
41 words
The teething gel of claim 2 wherein the polyethylene glycol is a mixture of about 30 to 60% polyethylene glycol with an average molecular weight of 600 and about 5 to 15% polyethylene glycol with an average molecular weight of 3350.
Claim 15
Independent Claim
146 words
A method for adhering a local anesthetic to the moist membranes of the lips and mouth area or gums of a teething child for affording a continued release of anesthetic for over 180 minutes at the moist site of application consisting essentially of: (a) applying to the moist membranes a teething gel containing from about 5 to 10% benzocaine; 5 to 20% NaCMC; and agent selected from the group consisting of 5 to 20% xanthan gum and 10 to 20% sodium alginate and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected form the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 16
Independent Claim
146 words
A method for adhering a local anesthetic to the moist membranes of the lips and mouth area or gums of a teething child for affording a continued release of anesthetic for over 180 minutes at the moist site of application consisting essentially of: (a) applying to the moist membranes a teething gel containing from about 5 to 10% benzocaine; 5 to 20% NaCMC; and agent selected from the group consisting of 5 to 20% xanthan gum and 10 to 20% sodium alginate and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected form the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 17
Independent Claim
126 words
A method for adhering a local anesthetic to the moist membranes of the lips and mouth area or gums of a teething child for affording a continued release of anesthetic for over 180 minutes at the moist site of application consisting essentially of: (a) applying to the moist membranes a teething gel containing from about 5 to 10% benzocaine; 5 to 15% glycerine; 5 to 20% NaCMC; 5 to 20% xanthan gum; and 35 to 75% polyethylene glycol wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 18
Independent Claim
126 words
A method for adhering a local anesthetic to the moist membranes of the lips and mouth area or gums of a teething child for affording a continued release of anesthetic for over 180 minutes at the moist site of application consisting essentially of: (a) applying to the moist membranes a teething gel containing from about 5 to 10% benzocaine; 5 to 15% glycerine; 5 to 20% NaCMC; 5 to 20% xanthan gum; and 35 to 75% polyethylene glycol wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 19
Independent Claim
132 words
A method for adhering a local anesthetic to the moist membranes of the lips and mouth area or gums of a teething child for affording a continued release of anesthetic for over 180 minutes at the moist site of application consisting essentially of: (a) applying to the moist membranes a teething gel containing from about 5 to 10% benzocaine; 5 to 20% NaCMC; 10 to 20% sodium alginate; and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
Claim 20
Independent Claim
132 words
A method for adhering a local anesthetic to the moist membranes of the lips and mouth area or gums of a teething child for affording a continued release of anesthetic for over 180 minutes at the moist site of application consisting essentially of: (a) applying to the moist membranes a teething gel containing from about 5 to 10% benzocaine; 5 to 20% NaCMC; 10 to 20% sodium alginate; and a diluent selected from the group consisting of polyethylene glycol and polyethylene glycol with glycerine wherein the percentages are by percent weight of the teething gel and optionally there may be added to said teething gel an effective amount of a pharmaceutically acceptable excipient selected from the group consisting of acidifying agents, antimicrobial preservatives, antioxidants, buffering agents, colorings, flavors, sweeteners and mixtures thereof.
References Cited (Backward Citations)
GB979909A
Cited
US3257276A
Cited
US4292299A
Cited
US4241048A
Cited
JPS57142913A
Cited
US4518721A
Cited
US4659696A
Cited
JPS6011631A
Cited
US5057306A
Cited
GB2181957A
Cited
US5057307A
Cited
US5009881A
Cited
US4844902A
Cited
US4894232A
Cited
EP0288945A2
Cited
US4867970A
Cited
US4981875A
Cited
EP0307599A1
Cited
US5059189A
Cited
EP0336901A2
Cited
US4913948A
Cited
WO1989010117A1
Cited
JPH01279838A
Cited
US4999342A
Cited
US4989607A
Cited
WO1990012588A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-03-08 | 1996-09-07 | 1997-03-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-03-08 | 2000-09-07 | 2001-03-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-03-08 | 2004-09-07 | 2005-03-09 | $7700.00 | Window Closed / Lapsed |