Patent US5645882A successfully refreshed from Google Patents.
US5645882A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
Assignee: Alcon Research LLC
•
Filing: 1995-11-29
•
Granted: 1997-07-08
•
Expires: 2015-11-29
Abstract
Abstract Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized end-capped PEO which is attached at one end to the medical device. The PEO compounds are then exposed to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network. These PEO coatings am able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.
Inventors
- 👤 Gerard Llanos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 15:53
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/06; A61L33/068
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
107 words
A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises (a) modifying the surface of the medical device in a heptylamine gas plasma; (b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and (c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and (d) sterilizing the medical device using ethylene oxide.
Claim 2
Independent Claim
107 words
A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises (a) modifying the surface of the medical device in a heptylamine gas plasma; (b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and (c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and (d) sterilizing the medical device using ethylene oxide.
References Cited (Backward Citations)
US3419600A
Cited
US4074713A
Cited
US4113088A
Cited
US4170043A
Cited
US4280970A
Cited
US4312575A
Cited
US4459317A
Cited
US4973493A
Cited
US5002582A
Cited
US4656083A
Cited
WO1986002087A1
Cited
US5043278A
Cited
US4871785A
Cited
US5169720A
Cited
US4961954A
Cited
US5290548A
Cited
US5094876A
Cited
US5100689A
Cited
US5061750A
Cited
US4834750A
Cited
US5070166A
Cited
US5182317A
Cited
US5225538A
Cited
US5080924A
Cited
US5326584A
Cited
US5118791A
Cited
US5116361A
Cited
US5002794A
Cited
US5275838A
Cited
US5455040A
Cited
US5290892A
Cited
US5252714A
Cited
US5344701A
Cited
US5409731A
Cited
US5331073A
Cited
US5308641A
Cited
US5229172A
Cited
US5401327A
Cited
WO1995016475A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-07-07 | 2001-01-06 | 2001-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-07 | 2005-01-06 | 2005-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-07 | 2009-01-06 | 2009-07-08 | $7700.00 | Window Closed / Lapsed |