US5169720A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Protein non-adsorptive polyurea-urethane polymer coated devices
Assignee: WR Grace and Co Conn
•
Filing: 1991-03-06
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Granted: 1992-12-08
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Expires: 2011-03-06
Abstract
Abstract Polymer-coated medical and laboratory devices are disclosed which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. The polyurea-polyurethane coatings of this invention are prepared from high molecular weight isocyanate end-capped prepolymers substantially or exclusively comprised of ethylene oxide units. At least 75%, preferably at least 90%, of the prepolymer units are oxyethylene-based diols or polyols having molecular weights of about 7000-30,000, with essentially all of the hydroxyl groups capped with polyisocyanate prior to formation of the hydrated polymer coating.
Inventors
- 👤 James A. Braatz
- 👤 Aaron H. Heifetz
- 👤 Clifton L. Kehr
- 👤 Richard A. Wolfe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:39
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54393; A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/06; A61L33/068; B; B01; B01D; B01D15/00; B01D15/08; B01D15/26; B01D15/34; B01J; B01J20/00; B01J20/02; B01J20/20; B01J20/22; B01J20/26; B01J20/262; B01J20/265; B01J20/267; B01J20/281; B01J20/286; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3214; B01J20/3225; B01J20/3227; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/3272; B01J20/328; B01J20/3282; C; C08; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/10; C08G18/28; C08G18/40; C08G18/48; C08G18/4825; C08G18/4829; C08G18/4833; C08G18/4837; C08G18/485; C08G18/70; C08G18/72; C08G18/74; C08G18/75; C08G18/751; C08G18/752; C08G18/753; C08G18/755; C08G18/76; C08G18/7614; C08G18/7621; C09; C09D; C09D175/00; C09D175/04; C12; C12N; C12N5/00; C12N5/0068; G01N33/54313; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; B01J2220/00; B01J2220/40; B01J2220/48; B01J2220/4812; B01J2220/49; B01J2220/50; B01J2220/54; C08G2210/00; C12N2533/00; C12N2533/30; Y; Y10; Y10S; Y10S528/00; Y10S528/904; Y10T; Y10T428/00; Y10T428/31504; Y10T428/31551; Y10T428/31569; Y10T428/31573; Y10T428/3158; Y10T428/31591; Y10T428/31598; Y10T428/31601
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
98 words
A biocompatible, protein non-adsorptive medical or laboratory device having a polymer coating on at least one surface thereof in which the polymer of said polymer coating is a hydrophilic, biocompatible hydrated polyurea-urethane polymer gel derived from prepolymer units at least 75% of which are oxyethylene-based diols or polyols having molecular weights of about 7000 to about 30,000, said diols or polyols having essentially all of the hydroxyl groups capped with polyisocyanate, said hydrated polymer gel characterized by transparency and by a surface having improved resistance to nonspecific protein adsorption, an formed by reacting said prepolymer units with water.
Claim 2
Dependent Claim
98 words
A biocompatible, protein non-adsorptive medical or laboratory device having a polymer coating on at least one surface thereof in which the polymer of said polymer coating is a hydrophilic, biocompatible hydrated polyurea-urethane polymer gel derived from prepolymer units at least 75% of which are oxyethylene-based diols or polyols having molecular weights of about 7000 to about 30,000, said diols or polyols having essentially all of the hydroxyl groups capped with polyisocyanate, said hydrated polymer gel characterized by transparency and by a surface having improved resistance to nonspecific protein adsorption, an formed by reacting said prepolymer units with water.
Claim 3
Dependent Claim
21 words
The polymer-coated device of claim 1 in which at least 90% of said prepolymer units are polyisocyanate-capped oxyethylene-based diols or polyols.
Claim 4
Dependent Claim
19 words
The polymer-coated device of claim 1 in which all of said prepolymer units are polyisocyanate-capped oxyethylene-based diols or polyols.
Claim 5
Dependent Claim
25 words
The polymer-coated device of claim 1 in which the molecular weight of said diols or polyols prior to capping with polyisocyanate is at least 10,000.
Claim 6
Dependent Claim
20 words
The polymer-coated device of claim 1 in which said diols or polyols are capped with an aliphatic or cycloaliphatic polyisocyanate.
Claim 7
Dependent Claim
13 words
The polymer-coated device of claim 5 in which said polyisocyanate is isophorone diisocyanate.
Claim 8
Dependent Claim
14 words
The polymer-coated device of claim 1 in which the polymer comprises an antioxidation agent.
Claim 9
Dependent Claim
39 words
The polymer-coated device of claim 1 in which said device comprises rubber, silicone, polyurethane polymer, Teflon (TM) polymer, polystyrene, woven or non-woven cloth or cloth-like material, silica or glass, charcoal, polyvinylchloride, poly-methylpentene, metal, wood or Tygon (TM) vinyl polymer.
Claim 10
Dependent Claim
43 words
The polymer-coated device of claim 1 which is a filter, an artificial organ or portion thereof, a extracorpeal therapeutic device, a cell culture or bioreactor system, device or portion thereof, or a protein isolation, preparation or purification device or system or portion thereof.
Claim 11
Dependent Claim
37 words
The polymer-coated device of claim 1 which is prepared by depositing a prepolymer-organic solvent solution on the uncoated device, removing excess organic solvent and then reacting the prepolymer with water to promote crosslinking on the substrate surface.
Claim 12
Dependent Claim
34 words
The polymer-coated device of claim 10 in which said organic solvent is selected from acetonitrile, dimethyl formamide, dimethyl sulfoxide, tetrahydrofuran, dioxane, acetone, methyl ethyl ketone, methanol, ethanol, 2-propanol, methylene chloride, dichloromethane, or mixtures thereof.
Claim 13
Dependent Claim
18 words
The polymer-coated device of claim 10 which comprises a monomolecular or substantially monomolecular layer on a coatable substrate.
Claim 14
Dependent Claim
34 words
The polymer-coated device of claim 1 which is prepared by depositing a prepolymer-organic solvent solution on the uncoated device, drying and then reacting the prepolymer with water to promote crosslinking on the substrate surface.
Claim 15
Dependent Claim
32 words
The polymer-coated device of claim 1 which is prepared by depositing a prepolymer-organic solvent solution on the uncoated device and reacting the prepolymer with water to promote crosslinking on the substrate surface.
Claim 16
Independent Claim
93 words
A method for improving medical or laboratory devices to increase biocompatibility and resistance to protein binding, comprising a) preparing a prepolymer-organic solvent solution, at least 75% of the prepolymer units of said prepolymer consisting of oxyethylene-based diols or polyols having molecular weights of about 7000 to about 30,000, said diols or polyols having essentially all of the hydroxyl groups capped with polyisocyanate, b) depositing said solution on a medical or laboratory device or portion thereof, c) forming a coating on said device, and d) reacting said coated device with water to promote crosslinking.
Claim 17
Independent Claim
93 words
A method for improving medical or laboratory devices to increase biocompatibility and resistance to protein binding, comprising a) preparing a prepolymer-organic solvent solution, at least 75% of the prepolymer units of said prepolymer consisting of oxyethylene-based diols or polyols having molecular weights of about 7000 to about 30,000, said diols or polyols having essentially all of the hydroxyl groups capped with polyisocyanate, b) depositing said solution on a medical or laboratory device or portion thereof, c) forming a coating on said device, and d) reacting said coated device with water to promote crosslinking.
Claim 18
Dependent Claim
16 words
The method of claim 15 in which the coating of step (c) is formed by drying.
Claim 19
Dependent Claim
21 words
The method of claim 15 in which said solution is deposited on said device by immersing said device in the solution.
Claim 20
Dependent Claim
35 words
The method of claim 15 in which the coating of step (c) is formed by allowing prepolymer to become deposited on, adsorbed to or impregnated in the surface of said device, and removing excess solution.
Claim 21
Dependent Claim
20 words
The method of claim 15 in which at least 90% of the prepolymer units are polyisocyanate-capped oxyethylene-based diols or polyols.
Claim 22
Dependent Claim
18 words
The method of claim 19 in which all of said prepolymer units are polyisocyanate-capped oxyethylene-based diols or polyols.
Claim 23
Dependent Claim
22 words
The method of claim 15 in which the prepolymer concentration of said solution is between about 0.01% and about 10.0% by weight.
Claim 24
Dependent Claim
21 words
The polymer-coated device of claim 9 in which the protein isolation, preparation or purification device is a membrane or particulate media.
Claim 25
Dependent Claim
17 words
The polymer-coated device of claim 22 in which said particulate media is a silica or charcoal particle.
Claim 26
Dependent Claim
10 words
A hemoperfusion system comprising the polymer-coated device of claim 1.
Claim 27
Dependent Claim
16 words
A hemoperfusion system of claim 24 in which the polymer-coated device is a filter or tubing.
Claim 28
Dependent Claim
10 words
A hemoperfusion system comprising the polymer-coated device of claim 23.
Claim 29
Dependent Claim
11 words
A diagnostic assay system comprising the polymer-coated device of claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-08 | 1996-06-08 | 1996-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-08 | 2000-06-08 | 2000-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-08 | 2004-06-08 | 2004-12-08 | $7700.00 | Window Closed / Lapsed |