US4127124A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Urethane bioimplant membrane
Assignee: WR Grace and Co
•
Filing: 1977-05-12
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Granted: 1978-11-28
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Expires: 1997-05-12
Abstract
Abstract Bioimplant three dimensional latice of hydrophilic polyurethane having a backbone of polyetherol or polyesterol, end-capped with aliphatic or aromatic diisocyanate, chain branched with polyol and bound into a latice by chain extension alkyl diols. The method of producing such a latice. An extension would be the use of the latice for other medical and veterinary purposes.
Inventors
- 👤 Donald C. Clagett
- 👤 Michael J. Svetly
- 👤 Peter H. Scott
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:31
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/08; C08G18/10; A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/425; A61L27/00; A61L27/14; A61L27/18; Y; Y10; Y10S; Y10S521/00; Y10S521/905; Y10S623/00; Y10S623/92; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249978
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
132 words
A method of implanting an unfoamed microporous hydrophilic bioimplant membrane within the living tissue in a mammal comprising the steps of producing a substantially unfoamed microporous hydrophilic bioimplant membrane by reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25%, volatilizing the solvent at a rate not causing the reaction product to foam whereby said unfoamed microporous hydrophilic bioimplant membrane is produced and placing the membrane so produced within the living tissue of a mammal.
Claim 2
Independent Claim
132 words
A method of implanting an unfoamed microporous hydrophilic bioimplant membrane within the living tissue in a mammal comprising the steps of producing a substantially unfoamed microporous hydrophilic bioimplant membrane by reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25%, volatilizing the solvent at a rate not causing the reaction product to foam whereby said unfoamed microporous hydrophilic bioimplant membrane is produced and placing the membrane so produced within the living tissue of a mammal.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the membrane is implanted beneath the panniculus carnosus.
Claim 4
Independent Claim
110 words
A method of placing a hydrophilic biononirritating material within the living tissue in a mammal comprising producing a hydrophilic biononirritating material by reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25%, volatilizing the solvent whereby said hydrophilic biononirritating material is produced and placing the material within the living tissue of a mammal.
Claim 5
Independent Claim
110 words
A method of placing a hydrophilic biononirritating material within the living tissue in a mammal comprising producing a hydrophilic biononirritating material by reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25%, volatilizing the solvent whereby said hydrophilic biononirritating material is produced and placing the material within the living tissue of a mammal.
Claim 6
Dependent Claim
14 words
The method of claim 3 wherein the material is placed beneath the panniculus carnosus.
Claim 7
Independent Claim
101 words
A method of producing a substantially unfoamed microporous hydrophilic bioimplant membrane comprising reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25% and volatilizing the solvent at a rate not causing the reaction product to foam and producing said unfoamed microporous hydrophilic bioimplant membrane.
Claim 8
Independent Claim
101 words
A method of producing a substantially unfoamed microporous hydrophilic bioimplant membrane comprising reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25% and volatilizing the solvent at a rate not causing the reaction product to foam and producing said unfoamed microporous hydrophilic bioimplant membrane.
Claim 9
Dependent Claim
49 words
The method of claim 1 wherein said isocyanate is an aliphatic diisocyanate; the diol is an alkyl diol, polyetherol oligomer or mixture of 2 or more of them; the solvent is a 3 to 5 membered ketone or mixture thereof; and the total solids concentration is 0.5 to 10%.
Claim 10
Dependent Claim
36 words
The method of claim 6 wherein said alphatic diisocyanate in the prepolymer is isophoronediisocyanate, the C 2 to C 6 diol is butane-1,4-diol, the solvent is acetone and the total solids concentration is 0.5 to 2%.
Claim 11
Dependent Claim
20 words
The method of claim 1 wherein a mono-alcohol chain stopper is included in the solvent reaction medium as a reactant.
Claim 12
Dependent Claim
68 words
The method of claim 1 wherein the isocyanate capped polyetherol or polyesterol is a diisocyanate end capped polyetherol and is dissolved in a non-aqueous solvent reaction medium to form a stock solution and said C 2 to C 6 diol is dissolved in a non-aqueous solvent reaction medium to form an activator solution and said reaction is brought about by combining said stock solution and said activator solution.
Claim 13
Dependent Claim
40 words
The method of claim 1 wherein said unfoamed microporous hydrophilic bioimplant membrane is free of silicon agents and chloroflurocarbons and has levels of free diisocyanate not exceeding 0.005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
Claim 14
Dependent Claim
63 words
The method of claim 9 wherein said diisocyanate end-capped polyetherol has an average molecular weight of less than 1250, said diol is a C 2 to C 5 diol, the solvent is a 3 to 5 membered anhydrous ketone or mixture thereof, the total solids concentration is 0.5 to 10% and the molar ratio of isocyanate monomer to diol is 1.5 to 3.
Claim 15
Dependent Claim
96 words
The method of claim 11 wherein said diisocyanate end-capped polyetherol is polyoxyethylene polyol and said diisocyanate capped polyoxyethylene polyol was prepared with a stannous octoate catalyst and contains a 2,6-disubstituted hindered phenol as an antioxidant, said diol is butane-1,4-diol, said solvent is acetone, the total solids concentration is 0.5 to 2%, the molar ratio of isocyanate monomer to diol is about 2, and said unfoamed microporous hydrophilic membrane is free of silicon agents and chlorofluorocarbons and has levels of free diisocyanate not exceeding 0.005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
Claim 16
Dependent Claim
90 words
A bioimplant member comprising a microporous molecular lattice of hydrophilic polyurethane, said polyurethane having a backbone chosen from the group consisting of polyetherols and polyesterols, or mixtures thereof, said backbone end-capped with isocyanate selected from the group consisting of aliphatic isocyanates and aromatic isocyanates, said urethane having chain branching centers of polyol, said branched urethane chains being bound by a C 2 to C 6 diol chain extension to form continuous three dimensional lattices and said urethane having a molar ratio of isocyanate to diol of from 1 to 3.5.
Claim 17
Dependent Claim
90 words
A bioimplant member comprising a microporous molecular lattice of hydrophilic polyurethane, said polyurethane having a backbone chosen from the group consisting of polyetherols and polyesterols, or mixtures thereof, said backbone end-capped with isocyanate selected from the group consisting of aliphatic isocyanates and aromatic isocyanates, said urethane having chain branching centers of polyol, said branched urethane chains being bound by a C 2 to C 6 diol chain extension to form continuous three dimensional lattices and said urethane having a molar ratio of isocyanate to diol of from 1 to 3.5.
Claim 18
Dependent Claim
16 words
The member of claim 13 wherein some of the urethane chains are chain stopped with alcohol.
Claim 19
Dependent Claim
54 words
The member of claim 13 wherein said isocyanate is an aliphatic diisocyanate; the diol is a C 2 to C 6 alkyl diol, polyetherol oligomer or mixture of 2 or more of them; the solvent is a 3 to 5 membered ketone or mixture thereof; and the total solids concentration is 0.5 to 10%.
Claim 20
Dependent Claim
29 words
The member of claim 13 wherein the isocyanate capped polyetherol or polyesterol is a diisocyanate end-capped polyetherol and said diol is a C 2 to C 6 alkyl diol.
Claim 21
Dependent Claim
41 words
The member of claim 13 wherein said microporous molecular lattice of hydrophilic polyurethane is free of silicon agents and chlorofluorocarbons and has levels of free diisocyanate not exceeding 0.005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
Claim 22
Dependent Claim
47 words
The member of claim 16 wherein said diisocyanate end-capped polyetherol or polyesterol is an etherol having an average molecular weight of less than 1250, said diol is a C 2 to C 5 diol, and the molar ratio of isocyanate monomer to diol is 1 to 3.5.
Claim 23
Dependent Claim
12 words
The member of claim 18 wherein a mono-alcohol chain stopper is included.
Claim 24
Dependent Claim
85 words
The member of claim 19 wherein said etherol of said diisocyanate end-capped polyetherol is polyoxyethylene polyol and said diisocyanate capped polyoxyethylene polyol was prepared with a stannous octoate catalyst and contains a 2,6-disubstituted hindered phenol as an antioxidant, said diol is butane-1,4-diol, the molar ratio of isocyanate monomer to diol is 1.5 to 3, and said member is free of silicon agents and chlorofluorocarbons and has levels of free diisocyanate not exceeding .005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
Claim 25
Independent Claim
86 words
A method of producing a hydrophilic biononirritating material comprising reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25% and volatilizing the solvent and producing said hydrophilic biononirritating material.
Claim 26
Independent Claim
86 words
A method of producing a hydrophilic biononirritating material comprising reacting a first component comprising isocyanate end-capped polyol chosen from the group consisting of polyetherol, polyesterol and mixtures thereof and having a reaction functionality of at least two with a second component comprising a C 2 to C 6 diol in an isocyanate monomer to diol molar ratio of 1 to 3.5 in a non-aqueous solvent reaction medium at a total solids concentration of less than 25% and volatilizing the solvent and producing said hydrophilic biononirritating material.
Claim 27
Dependent Claim
49 words
The method of claim 21 wherein said isocyanate is an aliphatic diisocyanate; the diol is an alkyl diol, polyetherol oligomer or mixture of 2 or more of them; the solvent is a 3 to 5 membered ketone or mixtures thereof; and the total solids concentration is 0.5 to 10%.
Claim 28
Dependent Claim
29 words
The method of claim 22 wherein said aliphatic diisocyanate is isophoronediisocyanate, the diol is butane-1, 4-diol, the solvent is acetone and the total solids concentration is 0.5 to 2%.
Claim 29
Dependent Claim
20 words
The method of claim 21 wherein a mono-alcohol chain stopper is included in the solvent reaction medium as a reactant.
Claim 30
Dependent Claim
67 words
The method of claim 21 wherein the isocyanate end-capped polyetherol or polyesterol is a diisocyanate end-capped polyetherol and is dissolved in a non-aqueous solvent reaction medium to form a stock solution and said C 2 to C 6 diol is dissolved in a non-aqueous solvent reaction medium to form an activator solution and said reaction is brought about by combining said stock solution and said activator solution.
Claim 31
Dependent Claim
38 words
The method of claim 21 wherein said hydrophilic biononirritating material is free of silicon agents and chlorofluorocarbons and has levels of free diisocyanate not exceeding 0.005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
Claim 32
Dependent Claim
108 words
The method of claim 25 wherein said etherol of said diisocyanate end-capped polyetherol is polyoxyethylene polyol with an average molecular weight of less than 1250, and said diisocyanate end-capped polyoxyethylene polyol was prepared with a stannous octoate catalyst and contains a 2,6-disubstituted hindered phenol as an antioxidant, said diol is butane-1,4-diol, said solvent is acetone, the total solids concentration is 0.5 to 2%, the molar ratio of isocyanate monomer to diol is 1.5 to 3, and said hydrophilic biononirritating material is free of silicon agents and chlorofluorocarbons and has levels of free diisocyanate not exceeding .005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
Claim 33
Dependent Claim
87 words
A substantially biononirritating material comprising a hydrophilic polyurethane, said polyurethane having a backbone chosen from the group consisting of polyetherols and polyesterols, or mixtures thereof, said backbone end-capped with isocyanate chosen from the group consisting of aliphatic isocyanates and aromatic isocyanates, said urethane having chain branching centers of polyol, said branched urethane chains being bound by a C 2 to C 6 diol chain extension to form continuous three dimensional lattices and said urethane having a molar ratio of isocyanate to diol of from 1 to 3.5.
Claim 34
Dependent Claim
87 words
A substantially biononirritating material comprising a hydrophilic polyurethane, said polyurethane having a backbone chosen from the group consisting of polyetherols and polyesterols, or mixtures thereof, said backbone end-capped with isocyanate chosen from the group consisting of aliphatic isocyanates and aromatic isocyanates, said urethane having chain branching centers of polyol, said branched urethane chains being bound by a C 2 to C 6 diol chain extension to form continuous three dimensional lattices and said urethane having a molar ratio of isocyanate to diol of from 1 to 3.5.
Claim 35
Dependent Claim
15 words
The material of claim 28 wherein some of urethane chains are chain stopped with alcohol.
Claim 36
Dependent Claim
36 words
The material of claim 28 wherein said diisocyanate end-capped polyetherol or polyesterol is an etherol having an average molecular weight of less than 1250 and said diol is a C 2 to C 6 alkyl diol.
Claim 37
Dependent Claim
20 words
The material of claim 30 wherein a monoalcohol chain stopper is included in the solvent reaction medium as a reactant.
Claim 38
Dependent Claim
85 words
The material of claim 31 wherein said etherol of said diisocyanate end-capped polyetherol is polyoxyethylene polyol and said diisocyanate capped polyoxyethylene polyol was prepared with a stannous octoate catalyst and contains a 2,6-disubstituted hindered phenol as an antioxidant, said diol is butane-1,4-diol, the molar ratio of isocyanate monomer to diol is 1.5 to 3, and said material is free of silicon agents and chlorofluorocarbons and has levels of free diisocyanate not exceeding 0.005 millimoles/gram and levels of free amines not exceeding 210 parts per million.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-27 | 1982-05-29 | 1982-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-27 | 1986-05-29 | 1986-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-27 | 1990-05-29 | 1990-11-28 | $7700.00 | Window Closed / Lapsed |