US5645882A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
Assignee: Alcon Research LLC
•
Filing: 1995-11-29
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Granted: 1997-07-08
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Expires: 2015-11-29
Abstract
Abstract Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized end-capped PEO which is attached at one end to the medical device. The PEO compounds are then exposed to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network. These PEO coatings am able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.
Inventors
- 👤 Gerard Llanos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:07
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/06; A61L33/068
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
107 words
A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises (a) modifying the surface of the medical device in a heptylamine gas plasma; (b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and (c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and (d) sterilizing the medical device using ethylene oxide.
Claim 2
Independent Claim
107 words
A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises (a) modifying the surface of the medical device in a heptylamine gas plasma; (b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and (c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and (d) sterilizing the medical device using ethylene oxide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-07-07 | 2001-01-06 | 2001-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-07 | 2005-01-06 | 2005-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-07 | 2009-01-06 | 2009-07-08 | $7700.00 | Window Closed / Lapsed |