US5612052A
Expired / Lapsed
US
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Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
Assignee: Poly Med Inc
•
Filing: 1995-04-13
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Granted: 1997-03-18
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Expires: 2015-04-13
Abstract
Abstract The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections.
Inventors
- 👤 Shalaby W. Shalaby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:41
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/30; A61K47/34; A61L; A61L31/00; A61L31/04; A61L31/06; A61L31/14; A61L31/145; C; C08; C08G; C08G63/00; C08G63/66; C08G63/664
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
22 words
A hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 2
Dependent Claim
22 words
A hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 3
Dependent Claim
21 words
The copolymer of claim 1, wherein said copolymer comprises a hydrophobic polyester block X covalently bonded to a hydrophilic block Y.
Claim 4
Dependent Claim
10 words
The copolymer of claim 1, wherein said copolymer is carboxy-terminated.
Claim 5
Dependent Claim
18 words
A composition comprising: the copolymer according to claim 1; and a biologically active agent associated with said copolymer.
Claim 6
Dependent Claim
19 words
The copolymer of claim 4, wherein said agent is at least partially deposited on an absorbable, microparticulate solid carrier.
Claim 7
Dependent Claim
13 words
The copolymer of claim 4, wherein said agent is bonded to said copolymer.
Claim 8
Dependent Claim
11 words
The copolymer of claim 5, wherein carrier is a microporous carrier.
Claim 9
Dependent Claim
32 words
The copolymer of claim 2, wherein said blocks X and Y are covalently bonded together in an arrangement selected from the group consisting of X-Y-X, (X-Y) n , and branched structures thereof.
Claim 10
Dependent Claim
21 words
The copolymer of claim 8, wherein said hydrophilic block Y comprises less than 50 % of the mass of said copolymer.
Claim 11
Dependent Claim
20 words
The copolymer of claim 9, wherein said hydrophilic block Y comprises oxyethylene or a combination of oxyethylene and oxypropylene sequences.
Claim 12
Dependent Claim
20 words
The copolymer of claim 8, wherein said hydrophobic block X comprises greater than 50% of the mass of said copolymer.
Claim 13
Dependent Claim
23 words
The copolymer of claim 11, wherein said hydrophobic block is derived from ring opening polymerization of lactones or step-growth formation of alkylene oxalates.
Claim 14
Dependent Claim
10 words
The copolymer of claim 1, wherein said copolymer is extrudable.
Claim 15
Dependent Claim
12 words
The copolymer of claim 13, wherein said extrudable copolymer is a liquid.
Claim 16
Dependent Claim
17 words
The copolymer of claim 14, wherein said liquid is capable of being injectable into a biological site.
Claim 17
Dependent Claim
26 words
The copolymer of claim 14, wherein said liquid is obtained by combining a high molecular weight sample of said copolymer with a lower molecular weight component.
Claim 18
Dependent Claim
14 words
The copolymer of claim 16, wherein said lower molecular weight component is a plasticizer.
Claim 19
Dependent Claim
25 words
The copolymer of claim 17, wherein said plasticizer comprises said polymer wherein the hydrophilic block Y to hydrophobic block X ratio is greater than 1.
Claim 20
Dependent Claim
14 words
The copolymer of claim 1, wherein said hydrogel mass is reversible into a liquid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-03-17 | 2000-09-16 | 2001-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-03-17 | 2004-09-16 | 2005-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-03-17 | 2008-09-16 | 2009-03-18 | $7700.00 | Window Closed / Lapsed |