US5573668A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydrophilic microporous membrane for drug delivery devices and method for preparing same
Assignee: 3M Co
•
Filing: 1995-06-01
•
Granted: 1996-11-12
•
Expires: 2015-06-01
Abstract
Abstract Articles having a complex geometric configuration have hydrophilicity imparted to at least a portion of surfaces of the articles while substantially retaining the complex geometric configuration. The hydrophilicity is imparted by an extremely thin, self-interlocking shell of tactic, hydrophilic poly(vinyl alcohol) enveloping the surfaces. A tactic poly(vinyl alcohol) precursor applied to surfaces of the supporting structure is reacted in situ on the surfaces with a hydrolysis reagent to prepare the tactic, hydrophilic poly(vinyl alcohol) shell. The article having the hydrophilic shell is highly resistant to solvent washout. Hydrophilicity and hydrophobicity can be reversibly provided on regio-specific surfaces of the article. Articles in the form of membranes useful as drug delivery device components are also described.
Inventors
- 👤 Sharon K. Grosh
- 👤 David R. Gagnon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:04
CPC Classifications
C; C04; C04B; C04B41/00; C04B41/80; C04B41/81; C04B41/82; C04B41/83; A; A23; A23B; A23B2/00; A23B2/70; A23B2/704; A23B2/708; A23B2/712; A23B2/717; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K9/00; A61K9/70; A61K9/7023; B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; B01D71/00; B01D71/06; B01D71/38; B01D71/381; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3212; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/3272; B01J20/3291; B41; B41M; B41M5/00; B41M5/50; B41M5/52; B41M5/5254; B41M7/00; B65; B65D; B65D65/00; B65D65/38; B65D81/00; B65D81/24; B65D81/26; B65D81/266; B65D81/267; C04B41/45; C04B41/46; C04B41/48; C04B41/4857; C04B41/4869; C09; C09D; C09D129/00; C09D129/02; C09D129/04; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/084; H; H01; H01M; H01M50/00; H01M50/40; H01M50/409; H01M50/411; H01M50/414; H01M50/417; H01M50/423; H01M50/429; H01M50/449; H01M50/454; H01M50/489; H01M50/491; H01M50/494; Y; Y02; Y02E; Y02E60/00; Y02E60/10; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1334; Y10T428/1341
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
49 words
A microporous drug delivery membrane having a hydrophilic, polymeric shell, comprising: a supporting structure having a complex geometric configuration and surfaces about said structure and an extremely thin, self-interlocking, tactic, hydrophilic poly(vinyl alcohol) shell enveloping at least a portion of said surfaces while substantially retaining said complex geometric configuration.
Claim 2
Dependent Claim
49 words
A microporous drug delivery membrane having a hydrophilic, polymeric shell, comprising: a supporting structure having a complex geometric configuration and surfaces about said structure and an extremely thin, self-interlocking, tactic, hydrophilic poly(vinyl alcohol) shell enveloping at least a portion of said surfaces while substantially retaining said complex geometric configuration.
Claim 3
Dependent Claim
26 words
The membrane according to claim 1, wherein said membrane is a polyolefin rendered hydrophilic and having pores of from about 0.01 μm to about 20 μm.
Claim 4
Dependent Claim
26 words
The membrane according to claim 1, wherein said membrane has a complex geometric configuration and said shell substantially retains said complex geometric configuration of said membrane.
Claim 5
Dependent Claim
28 words
The membrane according to claim 1, wherein said shell is between about an average of 10 monolayers to about an average of 4000 monolayers thick on said surfaces.
Claim 6
Dependent Claim
31 words
The membrane according to claim 1, wherein said shell is substantially insoluble in solvents having a solubility parameter differential to a solubility parameter of poly(vinyl alcohol) of greater than about 0.4.
Claim 7
Dependent Claim
24 words
The membrane according to claim 1, wherein pores of said structure are larger than the mean free path of flowing molecules of the drug.
Claim 8
Dependent Claim
12 words
The membrane according to claim 1, wherein said polymeric membrane is hydrophobic.
Claim 9
Dependent Claim
34 words
The membrane according to claim 1, wherein said shell has a sufficient pore wetting surface energy to permit spontaneous wetting of the drug delivery membrane with water containing a drug and an optimal excipient.
Claim 10
Dependent Claim
31 words
A drug delivery device, comprising: a hypoallergenic pressure sensitive adhesive layer, a therapeutic agent, and a membrane of claim 1 contacting said adhesive layer and in communication with said therapeutic agent.
Claim 11
Dependent Claim
28 words
The drug delivery device according to claim 9, wherein said membrane is a polyolefin rendered hydrophilic and has pores of from about 0.01 μm to about 20 μm.
Claim 12
Dependent Claim
30 words
The drug delivery device according to claim 9, wherein said shell is between about an average of 10 monolayers to about an average of 4000 monolayers thick on said surfaces.
Claim 13
Dependent Claim
32 words
The drug delivery device according to claim 9, wherein said shell is substantially insoluble in solvents having a solubility parameter differential to a solubility parameter of poly(vinyl alcohol)of greater than about 0.4.
Claim 14
Dependent Claim
26 words
The drug delivery device according to claim 9, wherein pores of said structure are larger than the mean free path of flowing molecules of the drug.
Claim 15
Dependent Claim
22 words
The drug delivery device according to claim 9, wherein said membrane is between said therapeutic agent and said pressure sensitive adhesive layer.
Claim 16
Dependent Claim
19 words
The drug delivery device according to claim 9, wherein said membrane comprises a porous depot for said therapeutic agent.
Claim 17
Dependent Claim
26 words
The drug delivery device according to claim 9, wherein said transdermal delivery device further comprises an excipient in communication with said therapeutic agent and said membrane.
Claim 18
Dependent Claim
35 words
A drug delivery device, comprising: a hypoallergenic pressure sensitive adhesive layer, a therapeutic agent, optionally an excipient in a reservoir, and a membrane according to claim 1 contacting said adhesive layer and contacting the reservoir.
Claim 19
Dependent Claim
22 words
The drug delivery device according to claim 17, wherein said membrane is between said therapeutic agent and said pressure sensitive adhesive layer.
Claim 20
Dependent Claim
27 words
The drug delivery device according to claim 17, wherein said pressure sensitive adhesive layer is absent from a pathway from said reservoir to skin of a patient.
Claim 21
Dependent Claim
17 words
The drug delivery device according to claim 9, wherein the membrane is hydrated for use in iontophoresis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-11-12 | 2000-05-13 | 2000-11-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-11-12 | 2004-05-13 | 2004-11-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-11-12 | 2008-05-13 | 2008-11-12 | $7700.00 | Window Closed / Lapsed |