US4731049A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cell for electrically controlled transdermal drug delivery
Assignee: IONICS INCORPORATED 65 GROVE STREET WATERTOWN MASSACHUSETTS 02172
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Filing: 1987-01-30
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Granted: 1988-03-15
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Expires: 2007-01-30
Abstract
Abstract A cell for electrically controlled drug delivery into and through the skin consisting of a source of current, an electrode, and a drug reservoir in which a drug is bound by an ion exchange medium or an immobilized ligand affinity medium. An additional ion reservoir may be interposed between the electrode and the drug reservoir and semi-permeable membranes are employed as barriers between the various components of the device as required.
Inventors
- 👤 Edgardo J. Parsi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:54
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; A61N1/0444; A61N1/0448
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
61 words
A cell for the electrically controlled delivery of a drug into and through the skin of a subject patient comprising in combination: a. a drug reservoir containing therein a drug bound to an immobilized ligand affinity medium or an ion-exchange medium; b. an electrode communicating with said reservoir; and c. a source of current connected between said electrode and said skin.
Claim 2
Dependent Claim
61 words
A cell for the electrically controlled delivery of a drug into and through the skin of a subject patient comprising in combination: a. a drug reservoir containing therein a drug bound to an immobilized ligand affinity medium or an ion-exchange medium; b. an electrode communicating with said reservoir; and c. a source of current connected between said electrode and said skin.
Claim 3
Dependent Claim
18 words
The apparatus of claim 1 further including a semi-permeable membrane interposed between said drug reservoir and the skin.
Claim 4
Dependent Claim
19 words
The apparatus of claim 2 further including a layer of hydrophilic medium interposed between said membrane and said skin.
Claim 5
Dependent Claim
99 words
A cell for use in the electrically controlled delivery of a drug into the skin of a subject patient comprising in combination: a. a drug reservoir containing therein a drug bound to an immobilized ligand affinity medium or an ion-exchange medium; b. a first semi-permeable barrier interposed between said drug reservoir and said skin; c. an ion reservoir positioned adjacent to said drug reservoir; d. a second semi-permeable barrier interposed between said drug reservoir and said ion reservoir; e. an electrode communicating with said ion reservoir; and f. a source of current connected between said electrode and said skin.
Claim 6
Dependent Claim
99 words
A cell for use in the electrically controlled delivery of a drug into the skin of a subject patient comprising in combination: a. a drug reservoir containing therein a drug bound to an immobilized ligand affinity medium or an ion-exchange medium; b. a first semi-permeable barrier interposed between said drug reservoir and said skin; c. an ion reservoir positioned adjacent to said drug reservoir; d. a second semi-permeable barrier interposed between said drug reservoir and said ion reservoir; e. an electrode communicating with said ion reservoir; and f. a source of current connected between said electrode and said skin.
Claim 7
Dependent Claim
19 words
The apparatus of claim 4 wherein said electrode comprises an anode and said ion reservoir comprises a cation reservoir.
Claim 8
Dependent Claim
19 words
The apparatus of claim 4 further including a hydrophilic reservoir interposed between said first semi-permeable barrier and said skin.
Claim 9
Dependent Claim
18 words
The apparatus of claim 4 wherein said drug reservoir contains a drug bound on an ion exchange resin.
Claim 10
Dependent Claim
19 words
The apparatus of claim 4 wherein said drug reservoir contains a drug bound on an immobilized ligand affinity medium.
Claim 11
Dependent Claim
80 words
The apparatus of claim 4 further including an additional cell for grounding said cell containing said drug reservoir comprising in combination: a. a second ion reservoir; b. a second hydrophilic medium interposed between said skin and said second ion reservoir; c. a semi-permeable barrier interposed between said second ion reservoir and said second hydrophilic medium; and d. a second electrode of opposite polarity to said drug reservoir electrode connected to said current source and communicating with said second ion reservoir.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-15 | 1991-09-14 | 1992-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-15 | 1995-09-14 | 1996-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-15 | 1999-09-14 | 2000-03-15 | $7700.00 | Window Closed / Lapsed |