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US4181128A
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US
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Virus inactivation applicator and the like
Assignee: Massachusetts Institute of Technology
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Filing: 1978-02-21
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Granted: 1980-01-01
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Expires: 1998-02-21
Abstract
Abstract A system for inactivation of microorganisms (viruses, bacteria, toxins and cells) such as, for example, Herpes simplex viruses by superposition of a component such as, for example, methylene blue (MB) plus light, oxygen and electricity. The system serves to generate the superoxide radical anion (O 2 ) and consequently hydrogen peroxide (H 2 O 2 ) and the hydroxyl radical (OH.), both of which enter into the inactivation process, but each has use beyond said system.
Inventors
- 👤 Mitchell R. Swartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:15
CPC Classifications
C; C12; C12N; C12N7/00; C01; C01B; C01B15/00; C01B15/01; C12N13/00; G; G01; G01N; G01N33/00; G01N33/0004; G01N33/0009; G01N33/007; A; A61; A61N; A61N5/00; A61N5/06; A61N2005/0635; A61N2005/0643; A61N2005/0644; A61N2005/065; A61N2005/0651; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16611; C12N2710/16661
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
75 words
A method of inactivating Herpes simplex virus, in vivo, that comprises applying to the region occupied by the Herpes simplex virus a solution containing a component capable of assuming an excited electronic state when said component is subjected to light and an electric field concurrently; concurrently applying an electric field to said region and directing light thereon; and adding hydrogen peroxide to said region to enhance formation of hydroxyl free radical by the Haber-Weiss reaction.
Claim 2
Independent Claim
75 words
A method of inactivating Herpes simplex virus, in vivo, that comprises applying to the region occupied by the Herpes simplex virus a solution containing a component capable of assuming an excited electronic state when said component is subjected to light and an electric field concurrently; concurrently applying an electric field to said region and directing light thereon; and adding hydrogen peroxide to said region to enhance formation of hydroxyl free radical by the Haber-Weiss reaction.
Claim 3
Independent Claim
66 words
A method of inactivating Herpes simplex virus, in vivo, that comprises applying to the region occupied by the Herpes simplex virus a solution containing a component capable of assuming an excited electronic state when said component is subjected to light and an electric field concurrently; concurrently applying an electric field to said region and directing light thereon; and applying a gelatinous carrier matrix to said region.
Claim 4
Independent Claim
66 words
A method of inactivating Herpes simplex virus, in vivo, that comprises applying to the region occupied by the Herpes simplex virus a solution containing a component capable of assuming an excited electronic state when said component is subjected to light and an electric field concurrently; concurrently applying an electric field to said region and directing light thereon; and applying a gelatinous carrier matrix to said region.
Claim 5
Independent Claim
70 words
A method of inactivating viruses, cells and the like, in situ, that comprises: applying to a lesion containing the viruses, cells and the like an active component capable of assuming an excited electronic state when subjected to light and an electric field concurrently; and concurrently applying an electric field to the region of the lesion to which the active component has been applied and directing light upon the same region.
Claim 6
Independent Claim
70 words
A method of inactivating viruses, cells and the like, in situ, that comprises: applying to a lesion containing the viruses, cells and the like an active component capable of assuming an excited electronic state when subjected to light and an electric field concurrently; and concurrently applying an electric field to the region of the lesion to which the active component has been applied and directing light upon the same region.
Claim 7
Dependent Claim
14 words
A method as claimed in claim 3 wherein said active component is methylene blue.
Claim 8
Dependent Claim
13 words
A method as claimed in claim 3 wherein said active component is methylthionine.
Claim 9
Dependent Claim
14 words
A method as claimed in claim 3 wherein the active component is toluidine blue.
Claim 10
Dependent Claim
47 words
A method as claimed in claim 3 that comprises applying a voltage to effect mass migration of the active component to selected sites, raising an electric current through said sites, and regulating both the voltage and the electric current to predetermined maximum values for predetermined maximum times.
Claim 11
Independent Claim
62 words
A method of inactivating viruses, cells and the like, in vivo, that comprises: applying to the region occupied by the virus, cells and the like, a solution containing a component capable of assuming an excited electronic state when said component is subjected to light and an electric field concurrently; and concurrently applying an electric field to said region and directing light thereupon.
Claim 12
Independent Claim
62 words
A method of inactivating viruses, cells and the like, in vivo, that comprises: applying to the region occupied by the virus, cells and the like, a solution containing a component capable of assuming an excited electronic state when said component is subjected to light and an electric field concurrently; and concurrently applying an electric field to said region and directing light thereupon.
Claim 13
Dependent Claim
14 words
A method as claimed in claim 8 wherein said active component is methylene blue.
Claim 14
Dependent Claim
14 words
A method as claimed in claim 8 wherein said active component is toluidine blue.
Claim 15
Dependent Claim
13 words
A method as claimed in claim 8 wherein said active component is methylthionine.
Claim 16
Dependent Claim
49 words
A method as claimed in claim 8 that comprises applying a voltage to effect mass migration of said component to selected sites in said region, passing an electric current through said sites, and regulating both the voltage and the electric current to predetermined maximum values for predetermined maximum times.
Claim 17
Dependent Claim
19 words
A method as claimed in claim 8 that further includes adding zinc oxide to said region to promote healing.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-31 | 1983-07-02 | 1984-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-31 | 1987-07-02 | 1988-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-31 | 1991-07-02 | 1992-01-01 | $7700.00 | Window Closed / Lapsed |