US5037656A
Expired / Lapsed
US
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Porous membrane having hydrophilic and cell growth promotions surface and process
Assignee: EMD Millipore Corp
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Filing: 1989-09-08
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Granted: 1991-08-06
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Expires: 2009-09-08
Abstract
Abstract A composite, porous membrane is formed from a porous polymer membrane having desired bulk properties on which is directly coated a cell attachment and/or growth promoting composition and a cross-linked polymer having desired surface properties. The composite membrane retains the porosity of the porous polymeric membrane. In one embodiment, when the substrate is polytetrafluoroethylene the composite is microscopically transparent.
Inventors
- 👤 Aldo M. Pitt
- 👤 Michael J. Steuck
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:39
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0088; C; C08; C08J; C08J7/00; C08J7/12; C08J7/16; C12; C12M; C12M25/00; C12M25/02; C12N; C12N5/00; C12N5/0068; B01D2323/00; B01D2323/30; C08J2327/00; C08J2327/02; C08J2327/12; C08J2327/18; C12N2533/00; C12N2533/30; C12N2533/50; C12N2533/54
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
76 words
A composite porous thermoplastic membrane which comprises a porous first polymer substrate membrane having an average pore size between about 0.001 and 15 microns, said membrane being directly coated on its entire surface with a collagen and a cross-linked second polymer formed from a monomer polymerized in situ with a free radical initiator and cross linked in situ on said substrate, said composite porous membrane having essentially the same porous configuration as said porous membrane substrate.
Claim 2
Dependent Claim
76 words
A composite porous thermoplastic membrane which comprises a porous first polymer substrate membrane having an average pore size between about 0.001 and 15 microns, said membrane being directly coated on its entire surface with a collagen and a cross-linked second polymer formed from a monomer polymerized in situ with a free radical initiator and cross linked in situ on said substrate, said composite porous membrane having essentially the same porous configuration as said porous membrane substrate.
Claim 3
Dependent Claim
13 words
The composite porous membrane of claims 1 wherein said polymer substrate is polytetrafluoroethylene.
Claim 4
Dependent Claim
13 words
The composite porous membrane of claims 1 wherein the polymer substrate is polycarbonate.
Claim 5
Dependent Claim
14 words
The composite porous membrane of claim 1 wherein the polymer substrate is a polyamide.
Claim 6
Dependent Claim
14 words
The composite porous membrane of claim 1 wherein the polymer substrate is polyvinylidene fluoride.
Claim 7
Dependent Claim
19 words
The composite porous membrane of claim 1 wherein the cell growth promoting composition contains Type I rat tail collagen.
Claim 8
Dependent Claim
18 words
The composite membrane of claim 1 wherein the cell growth promoting composition contains Type 1 bovine skin collagen.
Claim 9
Dependent Claim
17 words
The composite membrane of claim 1 wherein the substrate is polytetrafluoroethylene and the composite is microscopically transparent.
Claim 10
Dependent Claim
112 words
The process for forming a composite porous membrane formed from a porous first polymer substrate having an average pore size between about 0.001 and 15 microns, said substrate being directly coated over its entire surface with a collagen and a cross-linked second polymer, said composite porous membrane having essentially the same porous configuration as said porous membrane substrate which comprises: contacting said porous membrane with a solution of said collagen, a multifunctional monomer of said second polymer, and a free radical polymerization initiator under conditions to polymerize said monomer and to crosslink said second polymer over the entire surface of said porous polymer substrate under conditions to avoid plugging of said pores.
Claim 11
Dependent Claim
112 words
The process for forming a composite porous membrane formed from a porous first polymer substrate having an average pore size between about 0.001 and 15 microns, said substrate being directly coated over its entire surface with a collagen and a cross-linked second polymer, said composite porous membrane having essentially the same porous configuration as said porous membrane substrate which comprises: contacting said porous membrane with a solution of said collagen, a multifunctional monomer of said second polymer, and a free radical polymerization initiator under conditions to polymerize said monomer and to crosslink said second polymer over the entire surface of said porous polymer substrate under conditions to avoid plugging of said pores.
Claim 12
Dependent Claim
11 words
The process of claim 9 wherein said polymer substrate is polytetrafluoroethylene.
Claim 13
Dependent Claim
11 words
The process of claim 9 wherein said polymer substrate is polycarbonate.
Claim 14
Dependent Claim
11 words
The process of claim 9 wherein said polymer substrate is polyamide.
Claim 15
Dependent Claim
12 words
The process of claim 9 wherein said polymer substrate is polyvinylidene fluoride.
Claim 16
Dependent Claim
15 words
The process of claim 9 wherein said collagen composition contains Type I rat tail collagen.
Claim 17
Dependent Claim
14 words
The process of claim 9 wherein said collagen contains Type I bovine skin collagen.
Claim 18
Dependent Claim
158 words
The process for forming a composite hydrophilic porous membrane formed from a porous polytetrafluorethylene substrate having a pore size between about 0.001 and 15 microns, said substrate being directly coated over its entire surface with a collagen and a cross-linked second polymer, said composite porous membrane having essentially the same porous configuration as said porous membrane substrate which comprises: (a) washing said porous membrane substrate to wet the surfaces of the pores in said porous membrane; and (b) contacting said porous membrane with a solution of a collagen, a monomer of said second polymer, a polymerization initiator and a cross-linking agent for said monomer under conditions to polymerize said monomer and to cross-link said second polymer over the entire surface of said porous polytetrafluoroethylene substrate under conditions to avoid plugging of said pores, said solution comprising between about 10 and 90 weight percent water and between about 80 and 10 weight percent of a water miscible organic solvent.
Claim 19
Dependent Claim
158 words
The process for forming a composite hydrophilic porous membrane formed from a porous polytetrafluorethylene substrate having a pore size between about 0.001 and 15 microns, said substrate being directly coated over its entire surface with a collagen and a cross-linked second polymer, said composite porous membrane having essentially the same porous configuration as said porous membrane substrate which comprises: (a) washing said porous membrane substrate to wet the surfaces of the pores in said porous membrane; and (b) contacting said porous membrane with a solution of a collagen, a monomer of said second polymer, a polymerization initiator and a cross-linking agent for said monomer under conditions to polymerize said monomer and to cross-link said second polymer over the entire surface of said porous polytetrafluoroethylene substrate under conditions to avoid plugging of said pores, said solution comprising between about 10 and 90 weight percent water and between about 80 and 10 weight percent of a water miscible organic solvent.
Claim 20
Dependent Claim
13 words
The composite porous product of claim 1 wherein the polymer substrate is polypropylene.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-08-05 | 1995-02-04 | 1995-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-08-05 | 1999-02-04 | 1999-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-08-05 | 2003-02-04 | 2003-08-06 | $7700.00 | Window Closed / Lapsed |