US5512329A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substrate surface preparation
Assignee: Surmodics Coatings LLC
•
Filing: 1993-12-27
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Granted: 1996-04-30
•
Expires: 2013-12-27
Abstract
Abstract Surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation (e.g., actinic radiation) of latent reactive groups, such as photoactivatable ketones, carried by the polymer molecules. The initial surfaces are free of chemical groups added by surface pretreatement and which chemically participate in the covalent bonding process.
Inventors
- 👤 Patrick E. Guire
- 👤 Shawn G. Dunkirk
- 👤 Mark W. Josephson
- 👤 Melvin J. Swanson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:02
CPC Classifications
G; G02; G02C; G02C7/00; G02C7/02; G02C7/04; A; A61; A61F; A61F2/00; A61F2/0077; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61L; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; C; C12; C12N; C12N11/00; C12N11/02; C12N11/06; C12N5/00; C12N5/0068; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/543; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; A61L2400/00; A61L2400/18; C12N2533/00; C12N2533/30; C12N2533/50; C12N2533/54; C12N2533/70; C12N2533/78; C12N2533/80
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
113 words
A method of providing a substrate having a solid surface, the method comprising the steps of: (a) providing a polymer, (b) contacting the substrate surface with a composition comprising a plurality of molecules of the polymer, each having covalently bonded to it at least one latent reactive group capable of active specie generation in response to application of an external stimulus, under conditions which enable the polymer molecules to orient spatially so as to enable the latent reactive groups to come into covalent bonding proximity with the substrate surface; and (c) thereafter activating the latent reactive groups by application of the external stimulus to covalently bond the polymer molecules to the substrate surface.
Claim 2
Independent Claim
113 words
A method of providing a substrate having a solid surface, the method comprising the steps of: (a) providing a polymer, (b) contacting the substrate surface with a composition comprising a plurality of molecules of the polymer, each having covalently bonded to it at least one latent reactive group capable of active specie generation in response to application of an external stimulus, under conditions which enable the polymer molecules to orient spatially so as to enable the latent reactive groups to come into covalent bonding proximity with the substrate surface; and (c) thereafter activating the latent reactive groups by application of the external stimulus to covalently bond the polymer molecules to the substrate surface.
Claim 3
Dependent Claim
11 words
A method according to claim 1 wherein the polymer comprises fibronectin.
Claim 4
Dependent Claim
14 words
A method according to claim 1 wherein the polymer comprises a cell attachment factor.
Claim 5
Independent Claim
12 words
A method according to claim I wherein the substrate surface is polystyrene.
Claim 6
Dependent Claim
12 words
A method according to claim 1 wherein the substrate surface is silicone.
Claim 7
Dependent Claim
13 words
A method according to claim 1 wherein the external stimulus comprises actinic radiation.
Claim 8
Dependent Claim
22 words
A method according to claim 6 wherein the substrate surface is substantially free of functional groups added by pretreatment of the surface.
Claim 9
Dependent Claim
13 words
A method according to claim 6 wherein the polymer is a synthetic polymer.
Claim 10
Dependent Claim
12 words
A method according to claim 6 wherein the substrate surface is polystyrene.
Claim 11
Dependent Claim
12 words
A method according to claim 6 wherein the substrate surface is silicone.
Claim 12
Independent Claim
107 words
A method of providing a substrate having a surface, the method comprising the steps of: (a) providing a polymer, (b) contacting the substrate surface with a composition comprising a plurality of molecules of the polymer, each having covalently bonded to it at least one latent reactive group selected from the group consisting of photoactivatable ketones under conditions which enable the polymer to orient spatially so as to enable the latent reactive groups to come into covalent bonding proximity with the substrate surface; and (c) thereafter activating the latent reactive groups by the application of the external stimulus to covalently bond the polymer molecules to the substrate surface.
Claim 13
Independent Claim
107 words
A method of providing a substrate having a surface, the method comprising the steps of: (a) providing a polymer, (b) contacting the substrate surface with a composition comprising a plurality of molecules of the polymer, each having covalently bonded to it at least one latent reactive group selected from the group consisting of photoactivatable ketones under conditions which enable the polymer to orient spatially so as to enable the latent reactive groups to come into covalent bonding proximity with the substrate surface; and (c) thereafter activating the latent reactive groups by the application of the external stimulus to covalently bond the polymer molecules to the substrate surface.
Claim 14
Dependent Claim
20 words
A method according to claim 11 wherein the photoactivatable ketone is selected from the group consisting of benzophenones and acetophenones.
Claim 15
Dependent Claim
12 words
A method according to claim 12 where the photoactivatable ketone is benzophenone.
Claim 16
Dependent Claim
133 words
A method according to claim 11 wherein the method is used to modify the surface properties of a substrate having a solid surface, the method comprising the steps of: (a) providing a polymer having physical/chemical properties that are different than the physical/chemical properties of the substrate, (b) contacting the substrate surface with a composition comprising a plurality of molecules of the polymer, each having covalently bonded to it at least one latent reactive group selected from the group consisting of photoactivatable ketones under conditions which enable the polymer to orient spatially so as to enable the latent reactive groups to come into covalent bonding proximity with the substrate surface; and (c) thereafter activating the latent reactive groups by application of the external stimulus to covalently bond the polymer molecules to the substrate surface.
Claim 17
Dependent Claim
37 words
A method according to claim 14 wherein the polymer is used to modify the surface by providing it with a physical/chemical property selected from the group consisting of hydrophilic, hydrophobic, solvophilic, protein repulsion, antithrombogenic, and hemostatic properties.
Claim 18
Dependent Claim
31 words
A method according to claim 11 further comprising the step of covalently bonding one or more further monomers, oligomers or polymers to the polymer molecules covalently bound to the substrate surface.
Claim 19
Dependent Claim
21 words
A method according to claim 16 wherein further monomers or oligomers are covalently bound by polymerization to the surface-bound polymer molecules.
Claim 20
Dependent Claim
19 words
A method according to claim 16 wherein further polymers are covalently bound by grafting to the surface-bound polymer molecules.
Claim 21
Dependent Claim
49 words
A method according to claim 14 wherein the polymer is used to modify the surface by providing it with a physical/chemical property in the form of reactivity for covalent bonding of one or more further monomers, oligomers or polymers to the polymer molecules covalently bound to the substrate surface.
Claim 22
Dependent Claim
30 words
A method according to claim 19 further comprising the step of covalently bonding one or more monomers, oligomers or polymers to the polymer molecules covalently bound to the substrate surface.
Claim 23
Dependent Claim
23 words
A method according to claim 20 wherein one or more monomers or oligomers are covalently bound by polymerization to the surface-bound polymer molecules.
Claim 24
Dependent Claim
19 words
A method according to claim 20 wherein further polymers are covalently bound by grafting to the surface-bound polymer molecules.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-30 | 1999-10-30 | 2000-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-30 | 2003-10-30 | 2004-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-30 | 2007-10-30 | 2008-04-30 | $7700.00 | Window Closed / Lapsed |