US4530974A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nonthrombogenic articles having enhanced albumin affinity
Assignee: The University of Texas System
•
Filing: 1982-07-13
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Granted: 1985-07-23
•
Expires: 2002-07-13
Abstract
Abstract Articles having reduced thrombogenicity when in contact with blood products containing albumin and methods of their use are provided. The articles comprise at the surface of blood contact a water insoluble polymeric substrate material having covalently attached thereon aliphatic extensions of 14 to 20 carbon units. When exposed to blood the aliphatic chain extensions provide a hydrophobic binding site for albumin. The articles when implemented with whole blood or blood products selectively enhance albumin affinity binding to the exclusion of other blood components, and subsequently minimize thrombus formation.
Inventors
- 👤 Mark S. Munro
- 👤 Alfred J. Quattrone
- 👤 Steven R. Ellsworth
- 👤 Robert C. Eberhart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:11
CPC Classifications
C; C08; C08J; C08J7/00; C08J7/12
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
66 words
A nonthrombogenic article adapted for use in contact with blood or blood products containing albumin, said article having on those surfaces which contact blood or blood products a water soluble, biocompatible, nonionic polymeric substrate having covalently attached thereon nonionic, aliphatic hydrocarbon extensions of 14 to 20 carbon atoms, the degree of aliphatic extension attachment effective to absorb albumin sufficient to retard thrombus formation on said surfaces.
Claim 2
Dependent Claim
66 words
A nonthrombogenic article adapted for use in contact with blood or blood products containing albumin, said article having on those surfaces which contact blood or blood products a water soluble, biocompatible, nonionic polymeric substrate having covalently attached thereon nonionic, aliphatic hydrocarbon extensions of 14 to 20 carbon atoms, the degree of aliphatic extension attachment effective to absorb albumin sufficient to retard thrombus formation on said surfaces.
Claim 3
Dependent Claim
13 words
The article of claim 1 wherein the aliphatic extensions are straight chained radicals.
Claim 4
Dependent Claim
12 words
The article of claim 1 wherein the aliphatic extensions are alkyl radicals.
Claim 5
Dependent Claim
12 words
The article of claim 1 wherein the aliphatic extensions are olefinic radicals.
Claim 6
Dependent Claim
16 words
The article of claims 2, 3 or 4 wherein the aliphatic extensions have 18 carbon atoms.
Claim 7
Dependent Claim
21 words
The article of claims 1 or 2 wherein the aliphatic extensions are myristryl, cetyl, octadecyl, arachidyl, oleyl or linoleyl or linolenyl.
Claim 8
Dependent Claim
22 words
The article of claim 1 wherein the polymeric substrate is polyurethane, polyamide, polyamine, polyacrylamide, polyimine, polyester, cellulosic, amino-modified polystyrenes or amino-substituted polyesters.
Claim 9
Dependent Claim
26 words
The article of claim 1 wherein the polymeric substrate provides an amino or imino functional group for the covalent binding site of the aliphatic hydrocarbon extentions.
Claim 10
Dependent Claim
12 words
The article of claim 1 wherein the polymeric substrate is structurally stable.
Claim 11
Dependent Claim
14 words
The article of claim 1 which further comprises albumin adsorbed to the hydrocarbon extensions.
Claim 12
Independent Claim
89 words
A method for rendering nonthrombogenic at least one surface of article adapted for use in contact with bood or blood products containing albumin, comprising establishing on said article surface a water insoluble biocompatible, nonionic polymer substrate having thereon abstractable hydrogen sites effective for covalent attachment, alkylating said substrate at said hydrogen sites with aliphatic hydrocarbon extensions of 14 to 20 carbon atoms, the degree of aliphatic extension attachment effective to provide a nonionic affinity binding site for an amount of albumin sufficient to retard thrombus formation on said surface.
Claim 13
Independent Claim
89 words
A method for rendering nonthrombogenic at least one surface of article adapted for use in contact with bood or blood products containing albumin, comprising establishing on said article surface a water insoluble biocompatible, nonionic polymer substrate having thereon abstractable hydrogen sites effective for covalent attachment, alkylating said substrate at said hydrogen sites with aliphatic hydrocarbon extensions of 14 to 20 carbon atoms, the degree of aliphatic extension attachment effective to provide a nonionic affinity binding site for an amount of albumin sufficient to retard thrombus formation on said surface.
Claim 14
Dependent Claim
13 words
The method of claim 11 wherein the aliphatic extensions are straight chained radicals.
Claim 15
Dependent Claim
12 words
The method of claim 11 wherein the aliphatic extensions are alkyl radicals.
Claim 16
Dependent Claim
12 words
The method of claim 11 wherein the aliphatic extensions are olefinic radicals.
Claim 17
Independent Claim
16 words
The method of claims 12, 13 or 14 wherein the aliphatic extensions have 18 carbon atoms.
Claim 18
Independent Claim
20 words
The method of claims 11 or 12 wherein the aliphatic extensions are myristryl, cetyl, octadecyl, arachidyl, oleyl, linoleyl or linolenyl.
Claim 19
Dependent Claim
22 words
The method of claim 11 wherein the polymeric substrate is polyurethane, polyamide, polyamine, polyacrylamide, polyimine, polyester, cellulosic, amino-modified polystyrene or amino-substituted polyesters.
Claim 20
Dependent Claim
26 words
The method of claim 11 wherein the polymeric substrate provides an amino or imino functional group for the covalent binding site of the aliphatic hydrocarbon extensions.
Claim 21
Dependent Claim
12 words
The method of claim 11 wherein the polymeric substrate is structurally stable.
Claim 22
Dependent Claim
14 words
The method of claim 11 which further comprises albumin adsorbed to the hydrocarbon extensions.
Claim 23
Dependent Claim
35 words
The article of claim 1 which is vascular graft tubing, dialysis tubing or membrane, blood oxygenator tubing or membrane, intra-aortic balloon, ultrafiltration membrane, blood bag, catheter, suture, soft or hard tissue prosthesis, or artificial organ.
Claim 24
Dependent Claim
47 words
The method of claim 11 wherein the article adapted for use in contact with blood or blood products is vascular graft tubing, dialysis tubing or membrane, blood oxygenator tubing or membrane, intra-aortic balloon, ultrafiltration membrane, blood bag, catheter, suture, soft or hard tissue prosthesis, or artificial organ.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-22 | 1989-01-21 | 1989-07-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-22 | 1993-01-21 | 1993-07-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-22 | 1997-01-21 | 1997-07-23 | $7700.00 | Window Closed / Lapsed |