US4066581A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for producing a bond between polyvinylene glycol and a substance containing primary amino groups
Assignee: Siemens Healthcare Diagnostics GmbH Germany
•
Filing: 1977-02-24
•
Granted: 1978-01-03
•
Expires: 1997-02-24
Abstract
Abstract A bond is produced between a synthetic polymer containing vicinal hydroxyl groups and a substance containing primary amino groups by treating the polymer with a medium to strong oxidant until a sufficient number of aldehyde groups is formed and then reacting the oxidation product with the substance containing primary amino groups.
Inventors
- 👤 Axel Sieber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:11
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/30; C08F8/32
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
50 words
A process for producing a bond between polyvinylene glycol and a substance containing primary amino groups, which comprises treating said polyvinylene glycol with a medium to strong oxidant until a sufficient number of aldehyde groups is formed and then reacting the oxidation product with the substance containing primary amino groups.
Claim 2
Dependent Claim
50 words
A process for producing a bond between polyvinylene glycol and a substance containing primary amino groups, which comprises treating said polyvinylene glycol with a medium to strong oxidant until a sufficient number of aldehyde groups is formed and then reacting the oxidation product with the substance containing primary amino groups.
Claim 3
Dependent Claim
28 words
The process of claim 1, wherein the substance containing primary amino groups is a biologically active substance or a substance capable of reacting with a biologically active substance.
Claim 4
Dependent Claim
42 words
The process of claim 2, wherein the biologically active substance is an enzyme, an activator, an inhibitor, an antigen or antibody, a plasma protein, a blood group specific substance, a polypeptide, a peptide, an amino acid, or a natural or synthetic effector.
Claim 5
Dependent Claim
49 words
The process of claim 1, wherein the oxidation product is first reacted with a bifunctional compound containing a primary amino group and the second functional group of the latter compound is then reacted with a biologically active substance or a substance capable of reacting with a biologically active substance.
Claim 6
Dependent Claim
16 words
The process of claim 1, wherein the polymer is polyvinylene glycol cross-linked with a bifuntional compound.
Claim 7
Dependent Claim
20 words
The process of claim 1, wherein the reaction product is treated with a reducing agent suitable to reduce Schiff's bases.
Claim 8
Dependent Claim
9 words
A product prepared by the method of claim 1.
References Cited (Backward Citations)
CA667451A
Cited
CA667985A
Cited
US2722525A
Cited
GB782507A
Cited
US2847398A
Cited
US2794013A
Cited
US2847402A
Cited
US2993030A
Cited
US3037965A
Cited
US3020290A
Cited
US3069391A
Cited
US3415804A
Cited
US3331800A
Cited
US3455884A
Cited
US3553310A
Cited
US3616229A
Cited
US4011377A
Cited
US3847743A
Cited
US4013514A
Cited
US3753861A
Cited
US3944525A
Cited
US4001264A
Cited
US4025391A
Cited
US4002531A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-02 | 1981-07-04 | 1982-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-02 | 1985-07-04 | 1986-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-02 | 1989-07-04 | 1990-01-03 | $7700.00 | Window Closed / Lapsed |