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US5484584A Expired / Lapsed US ⏱️ 0.0 years remaining

Therapeutic and diagnostic use of modified polymeric microcapsules

Assignee: The University of Texas System
•
Filing: 1992-07-17
•
Granted: 1996-01-16
•
Expires: 2012-07-17
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Abstract

Abstract The present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of radiodiagnostic agents in 1 mu m capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 mu m capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes microcapsules surface modified with hydroxyl groups. Various agents such as estrone may be attached to the microcapsules and effectively targeted to selected organs.

Inventors

  • 👤 Sidney Wallace
  • 👤 David Yang
  • 👤 Michael Wallace
  • 👤 Chun Li
  • 👤 Li-Ren Kuang

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 12:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K47/00; A61K47/50; A61K47/69; A61K47/6921; A61K47/6925; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447; A61K49/0476; A61K49/048; A61K51/00; A61K51/12; A61K51/1241; A61K51/1244; A61K51/1251; A61K9/1652; A61K9/167; A61K9/1682; A61K9/1694; A61P; A61P35/00; B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/12; B01J13/125; B01J13/20; A61K2123/00; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985

Claims Analysis

Total Claims: 17
Claim 1
Independent Claim 31 words
A method of selective in vivo delivery to uterus tissue comprising administering to a mammal an effective amount of a pharmaceutically acceptable preparation of poly(benzyl L-glutamate) microspheres covalently attached to estrone.
Claim 2
Independent Claim 31 words
A method of selective in vivo delivery to uterus tissue comprising administering to a mammal an effective amount of a pharmaceutically acceptable preparation of poly(benzyl L-glutamate) microspheres covalently attached to estrone.
Claim 3
Dependent Claim 13 words
The method of claim 1 wherein the estrone is attached with a polylinker.
Claim 4
Dependent Claim 13 words
The method of claim 2 wherein the polylinker is a lower alkyl group.
Claim 5
Dependent Claim 17 words
The method of claim 1 wherein the microspheres are about 2 to about 6 μm in diameter.
Claim 6
Dependent Claim 14 words
The method of claim 1 wherein the microspheres are about 1 μm in diameter.
Claim 7
Dependent Claim 12 words
The method of claim 1 wherein the administering is by intravascular injection.
Claim 8
Dependent Claim 12 words
The method of claim 1 wherein the microcapsules contain a labeling agent.
Claim 9
Dependent Claim 12 words
The method of claim 7 wherein the labeling agent is 131 I-iopanoate.
Claim 10
Dependent Claim 14 words
The method of claim 1, further including attaching the microspheres to 131 I-labeled tyramine.
Claim 11
Dependent Claim 6 words
Poly(benzyl-L-glutamate) microspheres covalently attached to estrone.
Claim 12
Dependent Claim 6 words
Poly(benzyl-L-glutamate) microspheres covalently attached to estrone.
Claim 13
Dependent Claim 15 words
The microspheres of claim 10 wherein the estrone is attached through an alkyl linker group.
Claim 14
Dependent Claim 12 words
The microspheres of claim 11 wherein the alkyl linker group is ethyl.
Claim 15
Dependent Claim 8 words
Poly(benzyl-L-glutamate) microspheres which are covalently linked to tyramine.
Claim 16
Dependent Claim 8 words
Poly(benzyl-L-glutamate) microspheres which are covalently linked to tyramine.
Claim 17
Dependent Claim 13 words
The microspheres of claim 13 wherein the tyramine is labeled with 131 I.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1999-01-15 1999-07-17 2000-01-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2003-01-15 2003-07-17 2004-01-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2007-01-15 2007-07-17 2008-01-16 $7700.00 Window Closed / Lapsed

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