US4413070A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyacrolein microspheres
Assignee: California Institute of Technology
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Filing: 1981-03-30
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Granted: 1983-11-01
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Expires: 2001-03-30
Abstract
Abstract Microspheres of acrolein homopolymers and co-polymer with hydrophillic comonomers such as methacrylic acid and/or hydroxyethylmethacrylate are prepared by cobalt gamma irradiation of dilute aqueous solutions of the monomers in presence of suspending agents, especially alkyl sulfates such as sodium dodecyl sulfate. Amine or hydroxyl modification is achieved by forming adducts with diamines or alkanol amines. Carboxyl modification is effected by oxidation with peroxides. Pharmaceuticals or other aldehyde reactive materials can be coupled to the microspheres. The microspheres directly form antibody adducts without agglomeration.
Inventors
- 👤 Alan Rembaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5138; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; C; C08; C08F; C08F16/00; C08F16/34; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
82 words
A composition comprising an aqueous suspension of small, polymeric microspheres having a diameter from 500 Angstroms to 10 microns comprising the addition interpolymerizate of a monomer mixture consisting essentially of: 20% to 90% by weight of an unsaturated aldehyde selected from acrolein and C 1 to C 8 aryl, alkyl or cycloalkyl derivatives thereof; 10% to 50% by weight of at least one addition copolymerizable mono-unsaturated, freely water-soluble acrylic comonomer substituted with a hydrophilic substituent selected from amino, carboxyl or hydroxyl; and
Claim 2
Dependent Claim
82 words
A composition comprising an aqueous suspension of small, polymeric microspheres having a diameter from 500 Angstroms to 10 microns comprising the addition interpolymerizate of a monomer mixture consisting essentially of: 20% to 90% by weight of an unsaturated aldehyde selected from acrolein and C 1 to C 8 aryl, alkyl or cycloalkyl derivatives thereof; 10% to 50% by weight of at least one addition copolymerizable mono-unsaturated, freely water-soluble acrylic comonomer substituted with a hydrophilic substituent selected from amino, carboxyl or hydroxyl; and
Claim 3
Dependent Claim
12 words
1 to 20% by weight of an addition copolymerizable, polyunsaturated cross-linking agent.
Claim 4
Dependent Claim
12 words
1 to 20% by weight of an addition copolymerizable, polyunsaturated cross-linking agent.
Claim 5
Dependent Claim
20 words
A composition according to claim 1 in which the diameter of the microspheres is from 100 Angstroms to 2000 Angstroms.
Claim 6
Dependent Claim
23 words
A composition according to claim 1 in which the aldehyde is selected from acrolein, methacrolein, alphaethyl acrolein, alpha-butylacrolein, alpha-chloroacrolein, betaphenylacrolein, alpha-cyclohexylacrolein and alpha-decylacrolein.
Claim 7
Dependent Claim
12 words
A composition according to claim 1 in which the aldehyde is acrolein.
Claim 8
Dependent Claim
72 words
A composition according to claim 1 in which the comonomer is selected from acrylamide, methacrylamide, acrylic acid, methacrylic acid, dimethylaminomethacrylate or compounds of the formula: ##STR3## where R 1 is hydrogen or lower alkyl of 1-8 carbon atoms, R 2 is alkylene of 1-12 carbon atoms and Z is --OH or ##STR4## where R 3 or R 4 are individually selected from H, lower alkyl or lower alkoxy of 1-8 carbon atoms.
Claim 9
Dependent Claim
13 words
A composition according to claim 5 in which the comonomer comprises hydroxyethyl methacrylate.
Claim 10
Dependent Claim
17 words
A composition according to claim 5 in which the comonomer imparts a negative charge to the microsphere.
Claim 11
Dependent Claim
13 words
A composition according to claim 7 in which said comonomer is methacrylic acid.
Claim 12
Dependent Claim
40 words
A composition according to claim 1 in which the cross-linking agent is present in an amount from 6 to 2% by weight and is selected from a polyvinyl diene or triene capable of addition polymerization with the covalent bonding monomer.
Claim 13
Dependent Claim
13 words
A composition according to claim 1 in which the cross-linking agent is bis-acrylamide.
Claim 14
Dependent Claim
31 words
A composition according to claim 1 in which the monomer mixture further includes 10% to 30% by weight of sparingly water soluble monomers selected from lower alkyl acrylates or vinyl pyridines.
Claim 15
Dependent Claim
19 words
A composition according to claim 1 further including 0.05 to 5% by weight of a copolymerizable fluorescent chromophore monomer.
Claim 16
Dependent Claim
17 words
A composition according to claim 12 in which the fluorescent monomer contains functional groups reactive with aldehyde.
Claim 17
Dependent Claim
16 words
A composition according to claim 13 in which the fluorescent monomer contains addition polymerizable unsaturated groups.
Claim 18
Dependent Claim
16 words
A composition according to claim 1 in which said microspheres contain a dispersion of metal particles.
Claim 19
Dependent Claim
12 words
A composition according to claim 15 in which the metals are magnetizable.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-31 | 1987-05-02 | 1987-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-31 | 1991-05-02 | 1991-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-31 | 1995-05-02 | 1995-11-01 | $7700.00 | Window Closed / Lapsed |