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Patent US5384062A successfully refreshed from Google Patents.
US5384062A
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US
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Perborate persulfate: protease denture cleanser tablet composition
Assignee: Blacksmith Brands Inc
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Filing: 1993-12-01
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Granted: 1995-01-24
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Expires: 2013-12-01
Abstract
Abstract An anhydrous denture cleansing composition is disclosed comprising anhydrous perborate, a perborate monohydrate, a lubricant and compression aid, a monopersulfate, one or proteolytic enzymes, a sequestering agent, and, optionally, excipients, builders, colors, flavors, and surfactants.
Inventors
- 👤 Anthony B. Eoga
- 👤 Richard G. Moran
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:19
CPC Classifications
A; A61; A61Q; A61Q11/00; A61Q11/02; A61K; A61K8/00; A61K8/02; A61K8/0216; A61K8/0241; A61K8/18; A61K8/19; A61K8/22; A61K8/30; A61K8/33; A61K8/38; A61K8/64; A61K8/66; A61K8/72; A61K8/81; A61K8/8123; C; C11; C11D; C11D17/00; C11D17/0047; C11D17/0065; C11D17/0073; C11D3/00; C11D3/16; C11D3/38; C11D3/386; C11D3/38609; C11D3/39; C11D3/3942; A61K2800/00; A61K2800/20; A61K2800/30; A61K2800/31
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
166 words
A denture cleansing composition in tablet form derived from a mixture comprising: (a) a pregranulated compressed mixture of an anhydrous perborate in an amount of from about 5% to about 25% by weight of said composition, a perborate monohydrate, and a lubricant and compression aid, wherein the weight ratio of anhydrous perborate to said perborate monohydrate in said pregranulated mixture is from about 1.3 to about 1:1the amount of perborate monohydrate in the premixture being reflected by the ratio; and (b) a monopersulfate compound in an amount of from about 15% to about 27% by weight of said composition; and (c) non-granulated perborate monohydrate wherein the total amount of granulated and non-granulated perborate monohydrate is in an amount of from about 30% to about 45% by weight of said denture cleansing composition; and (d) an effective amount of one or more proteolytic enzyme(s) to disrupt the proteinaceous material in plaque; and (e) an effective amount of a sequestering agent to remove calcium deposits and calculus deposits.
Claim 2
Dependent Claim
166 words
A denture cleansing composition in tablet form derived from a mixture comprising: (a) a pregranulated compressed mixture of an anhydrous perborate in an amount of from about 5% to about 25% by weight of said composition, a perborate monohydrate, and a lubricant and compression aid, wherein the weight ratio of anhydrous perborate to said perborate monohydrate in said pregranulated mixture is from about 1.3 to about 1:1the amount of perborate monohydrate in the premixture being reflected by the ratio; and (b) a monopersulfate compound in an amount of from about 15% to about 27% by weight of said composition; and (c) non-granulated perborate monohydrate wherein the total amount of granulated and non-granulated perborate monohydrate is in an amount of from about 30% to about 45% by weight of said denture cleansing composition; and (d) an effective amount of one or more proteolytic enzyme(s) to disrupt the proteinaceous material in plaque; and (e) an effective amount of a sequestering agent to remove calcium deposits and calculus deposits.
Claim 3
Dependent Claim
142 words
The denture cleansing composition of claim 1 wherein; said anhydrous perborate is potassium or sodium anhydrous perborate; (ii) said lubricant and compression aid is in an amount of from about 0.1% to about 0.8% by weight of said pregranulated compressed mixture, and wherein said lubricant and compression aid is polytetrafluorethylene; (iii) said monopersulfate compound is a triple potassium salt with the formula KHSO 5 .KHSO 4 .K 2 SO 4 and a mole ratio of 2:1:1, (iv) said proteolytic enzyme is in an amount of from about 0.2% to about 5% by weight of said composition, and wherein said proteolytic enzyme is a protease derived from a variant of Bacillus licheniformis; (v) said sequestering agent is in an amount of from about 1% to about 25% by weight of said composition, and wherein said sequestering agent is Na 4 EDTA.2H 2 O.
Claim 4
Dependent Claim
20 words
The composition of claim 1, wherein said anhydrous perborate comprises about 13% to about 14% by weight of said composition.
Claim 5
Dependent Claim
22 words
The composition of claim 1, wherein said perborate monohydrate comprises about 33% to about 35% by weight of the total cleansing composition.
Claim 6
Dependent Claim
13 words
The composition of claim 1 wherein said lubricant and compression aid is polytetrafluourethylene.
Claim 7
Dependent Claim
25 words
The composition of claim 1, wherein said lubricant and compression aid comprises from about 0.1% to about 0.8% by weight of the pregranulated compressed mixture.
Claim 8
Dependent Claim
31 words
The composition of claim 1 wherein said monopersulfate compound is a triple potassium salt with the formula KHSO 5 .KHSO 4 .K 2 SO 4 and a mole ratio of 2:1:1.
Claim 9
Dependent Claim
21 words
The composition of claim 7, wherein said monopersulfate compound comprises from about 15% to about 27% by weight of said composition.
Claim 10
Dependent Claim
11 words
The composition of claim 1, wherein said sequestering agent is EDTA.
Claim 11
Dependent Claim
14 words
The composition of claim 9, wherein said EDTA is Na 4 EDTA.2H 2 O.
Claim 12
Dependent Claim
24 words
The composition of claim 10, wherein said Na 4 EDTA.2H 2 O comprises from about 1% to about 25% by weight of said composition.
Claim 13
Dependent Claim
30 words
The composition of claim 11 wherein the mesh-size profile of said EDTA is a maximum of 25% through U.S.S. 100 mesh screen and 0% remaining on U.S.S. 20 mesh screen.
Claim 14
Dependent Claim
23 words
The composition of claim 10, wherein the chelating value of said Na 4 EDTA. 2 H 2 O is at least about 238.
Claim 15
Dependent Claim
16 words
The composition of claim 1 wherein said proteolytic enzyme is a protease derived from Bacillus lichenformis.
Claim 16
Dependent Claim
25 words
The composition of claim 1 wherein said proteolytic enzymes are present in an amount from about 0.2% to about 5% by weight of said composition.
Claim 17
Dependent Claim
23 words
The composition of claim 1, wherein said monopersulfate is selected from the group consisting of alkali metal monopersulfates and alkaline earth metal monopersulfates.
Claim 18
Dependent Claim
13 words
The composition of claim 1, wherein said monopersulfate is sodium or potassium monopersulfate.
Claim 19
Dependent Claim
24 words
The composition of claim 1, wherein said anhydrous perborate is selected from the group consisting of alkali metal perborates and alkaline earth metal perborates.
Claim 20
Dependent Claim
15 words
The composition of claim 1, wherein said anhydrous perborate is potassium or sodium anhydrous perborate.
Claim 21
Dependent Claim
22 words
The composition of claim 1, wherein the weight ratio of perborate monohydrate to anhydrous perborate to polymeric fluorocarbon compound is about 54.2:45.2:0.6.
Claim 22
Dependent Claim
15 words
The composition of claim 1, wherein said perborate monohydrate is potassium or sodium perborate monohydrate.
Claim 23
Dependent Claim
20 words
The composition of claim 1, wherein the weight ratio of perborate monohydrate/monopersulfate compound is from about 3:1 to about 1:1.
Claim 24
Dependent Claim
16 words
The composition of claim 22, wherein the weight ratio of perborate monohydrate/monopersulfate compound is about 1.7:1.
Claim 25
Dependent Claim
14 words
The composition of claim 1, wherein a detergent is a component of said composition.
Claim 26
Dependent Claim
12 words
The composition of claim 24, wherein said detergent is an anionic detergent.
Claim 27
Dependent Claim
24 words
The composition of claim 25, wherein said anionic detergent is present in the amount of up to about 5% by weight of the composition.
Claim 28
Dependent Claim
94 words
A process for preparing a denture cleansing tablet according to claim 24 comprising the step of: (a) preparing a compacted compressed mixture comprising anhydrous perborate salts and perborate monohydrate salts in combination with a lubricant and compression aid; and (b) grinding said compacted mixture into a pregranulation mixture, or premix; and (c) adding the pregranulation mixture, or premix, to the other materials in the denture cleansing composition and mixing; and (d) adding detergent to the mixture and mixing for up to 3 minutes; and (e) forming the resultant blended mixture into a cohesive tablet.
Claim 29
Dependent Claim
28 words
The process of claim 27 wherein said compacted mixture is pre-dried to a free moisture level of about 0.3% to about 1.5% by weight of the compacted mixture.
Claim 30
Dependent Claim
27 words
The process of claim 28 wherein said compacted mixture is pre-dried to a free moisture level of less than about 0.3% by weight of the compacted mixture.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-23 | 1998-07-25 | 1999-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-23 | 2002-07-25 | 2003-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-23 | 2006-07-25 | 2007-01-24 | $7700.00 | Window Closed / Lapsed |