US4155868A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enzyme and active oxygen containing denture cleanser tablet
Assignee: Johnson and Johnson
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Filing: 1977-03-02
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Granted: 1979-05-22
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Expires: 1997-03-02
Abstract
Abstract A completely water soluble effervescent denture cleanser tablet containing both an enzyme and one or more active oxygen compounds. The enzyme in said tablet is resistant to premature inactivation by the oxidizing agents in the tablet during storage and in use and therefore has the added enzymatic cleansing power not possessed by conventional tablets containing only the active oxygen compounds. A method for preparing enzyme-containing denture cleanser tablets in which the activity of the enzyme is usefully retained is also described.
Inventors
- 👤 Leonard L. Kaplan
- 👤 Norman A. Levin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 04:04
CPC Classifications
C; C11; C11D; C11D17/00; C11D17/0047; C11D17/0065; C11D17/0073; A; A61; A61K; A61K8/00; A61K8/02; A61K8/11; A61K8/18; A61K8/30; A61K8/33; A61K8/38; A61K8/64; A61K8/66; A61Q; A61Q11/00; A61Q11/02; C11D3/00; C11D3/0005; C11D3/0052; C11D3/16; C11D3/38; C11D3/386; C11D3/38609; A61K2800/00; A61K2800/20; A61K2800/22; A61K2800/222; A61K2800/40; A61K2800/41; A61K2800/412
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
258 words
A stable, water-soluble denture cleanser tablet providing enzymatic and active oxygen cleansing action consisting essentially of (a) from about 0.8 to about 3.5% by weight of a neutral bacterial protease enzyme of about 3 Anson Units activity; (b) from about 30 to about 50% by weight of at least one active oxygen compound which is selected from the group of peroxygen compounds which form hydrogen peroxide or nascent oxygen when placed in solution and is further selected from the group consisting of sodium perborate monohydrate, sodium perborate tetrahydrate, potassium persulfate, sodium carbonate peroxide, diperisophthalic acid, potassium peroxydiphosphate and sodium aluminum aminohydroperoxide; (c) from about 45 to about 65% by weight of at least one effervescence-producing composition which is selected from the group of carbon dioxide generating mixtures consisting essentially of at least one water-soluble organic acid selected from the group consisting of citric acid, tartaric acid, gluconic acid and malic acid and at least one alkali metal carbonate compound selected from the group consisting of sodium bicarbonate, potassium bicarbonate, sodium carbonate and potassium carbonate; and (d) from about 0.1 to about 5% by weight of at least one water-soluble lubricant selected from the group consisting of magnesium lauryl sulfate and a mixture of magnesium lauryl sulfate and polyethylene glycol having a molecular weight of from about 6000 to about 20,000; wherein said tablet has a moisture content not greater than about 0.1 percent based on the total weight of the tablet and upon dissolution in an aqueous medium has a pH of from about 6.0 to about 7.5.
Claim 2
Dependent Claim
258 words
A stable, water-soluble denture cleanser tablet providing enzymatic and active oxygen cleansing action consisting essentially of (a) from about 0.8 to about 3.5% by weight of a neutral bacterial protease enzyme of about 3 Anson Units activity; (b) from about 30 to about 50% by weight of at least one active oxygen compound which is selected from the group of peroxygen compounds which form hydrogen peroxide or nascent oxygen when placed in solution and is further selected from the group consisting of sodium perborate monohydrate, sodium perborate tetrahydrate, potassium persulfate, sodium carbonate peroxide, diperisophthalic acid, potassium peroxydiphosphate and sodium aluminum aminohydroperoxide; (c) from about 45 to about 65% by weight of at least one effervescence-producing composition which is selected from the group of carbon dioxide generating mixtures consisting essentially of at least one water-soluble organic acid selected from the group consisting of citric acid, tartaric acid, gluconic acid and malic acid and at least one alkali metal carbonate compound selected from the group consisting of sodium bicarbonate, potassium bicarbonate, sodium carbonate and potassium carbonate; and (d) from about 0.1 to about 5% by weight of at least one water-soluble lubricant selected from the group consisting of magnesium lauryl sulfate and a mixture of magnesium lauryl sulfate and polyethylene glycol having a molecular weight of from about 6000 to about 20,000; wherein said tablet has a moisture content not greater than about 0.1 percent based on the total weight of the tablet and upon dissolution in an aqueous medium has a pH of from about 6.0 to about 7.5.
Claim 3
Dependent Claim
17 words
A tablet according to claim 1 wherein the active oxygen compound is at least sodium perborate monohydrate.
Claim 4
Dependent Claim
16 words
A tablet according to claim 1 wherein the active oxygen compound is at least potassium persulfate.
Claim 5
Dependent Claim
16 words
A tablet according to claim 1 wherein the water-soluble organic acid is at least citric acid.
Claim 6
Dependent Claim
16 words
A tablet according to claim 1 wherein the water-soluble organic acid is at least tartaric acid.
Claim 7
Dependent Claim
17 words
A tablet according to claim 1 wherein the alkali metal carbonate compound is at least sodium bicarbonate.
Claim 8
Dependent Claim
17 words
A tablet according to claim 1 wherein the alkali metal carbonate compound is at least sodium carbonate.
Claim 9
Dependent Claim
30 words
A tablet according to claim 1 wherein the lubricant is a mixture of magnesium lauryl sulfate and polyethylene glycol having a molecular weight of from about 6000 to about 20,000.
Claim 10
Independent Claim
296 words
A method for cleaning dentures which comprises placing a water-soluble denture cleanser tablet and the denture to be cleaned in an amount of water sufficient to completely cover said denture and for a time sufficient to effect the desired cleaning; wherein said tablet provides enzymatic and active oxygen cleansing action and consists essentially of: (a) from about 0.8 to about 3.5% by weight of a neutral bacterial protease enzyme of about 3 Anson Units activity; (b) from about 30 to about 50% by weight of at least one active oxygen compound which is selected from the group of peroxygen compounds which form hydrogen peroxide or nascent oxygen when placed in solution and is further selected from the group consisting of sodium perborate monohydrate, sodium perborate tetrahydrate, potassium persulfate, sodium carbonate peroxide, diperisophthalic acid, potassium peroxydiphosphate and sodium aluminum aminohydroperoxide; (c) from about 45 to about 65% by weight of at least one effervescence-producing composition which is selected from the group of carbon dioxide generating mixtures consisting essentially of at least one water-soluble organic acid selected from the group consisting of citric acid, tartaric acid, gluconic acid and malic acid and at least one alkali metal carbonate compound selected from the group consisting of sodium bicarbonate, potassium bicarbonate, sodium carbonate and potassium carbonate; and (d) from about 0.1 to about 5% by weight of at least one water-soluble lubricant selected from the group consisting of magnesium lauryl sulfate and a mixture of magnesium lauryl sulfate and polyethylene glycol having a molecular weight of from about 6000 to about 20,000; wherein said tablet has a moisture content not greater than about 0.1 percent based on the total weight of the tablet and upon dissolution in an aqueous medium has a pH of from about 6.0 to about 7.5.
Claim 11
Independent Claim
296 words
A method for cleaning dentures which comprises placing a water-soluble denture cleanser tablet and the denture to be cleaned in an amount of water sufficient to completely cover said denture and for a time sufficient to effect the desired cleaning; wherein said tablet provides enzymatic and active oxygen cleansing action and consists essentially of: (a) from about 0.8 to about 3.5% by weight of a neutral bacterial protease enzyme of about 3 Anson Units activity; (b) from about 30 to about 50% by weight of at least one active oxygen compound which is selected from the group of peroxygen compounds which form hydrogen peroxide or nascent oxygen when placed in solution and is further selected from the group consisting of sodium perborate monohydrate, sodium perborate tetrahydrate, potassium persulfate, sodium carbonate peroxide, diperisophthalic acid, potassium peroxydiphosphate and sodium aluminum aminohydroperoxide; (c) from about 45 to about 65% by weight of at least one effervescence-producing composition which is selected from the group of carbon dioxide generating mixtures consisting essentially of at least one water-soluble organic acid selected from the group consisting of citric acid, tartaric acid, gluconic acid and malic acid and at least one alkali metal carbonate compound selected from the group consisting of sodium bicarbonate, potassium bicarbonate, sodium carbonate and potassium carbonate; and (d) from about 0.1 to about 5% by weight of at least one water-soluble lubricant selected from the group consisting of magnesium lauryl sulfate and a mixture of magnesium lauryl sulfate and polyethylene glycol having a molecular weight of from about 6000 to about 20,000; wherein said tablet has a moisture content not greater than about 0.1 percent based on the total weight of the tablet and upon dissolution in an aqueous medium has a pH of from about 6.0 to about 7.5.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-21 | 1982-11-20 | 1983-05-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-21 | 1986-11-20 | 1987-05-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-21 | 1990-11-20 | 1991-05-22 | $7700.00 | Window Closed / Lapsed |