Patent US5277915A successfully refreshed from Google Patents.
US5277915A
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Gel-in-matrix containing a fractured hydrogel
Assignee: Cambrex Bio Science Rockland Inc
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Filing: 1992-03-27
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Granted: 1994-01-11
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Expires: 2012-03-27
Abstract
Abstract A three dimensional porous matrix, such as a reticulated open-cell foam, having within its matrix structure a mechanically-fractured hydrogel containing a network of fracture channels. The mechanically-fractured hydrogel may be a gel that has been partially dewatered by compression of the gel in situ. The porosity of the gel-in-matrix makes it useful for chromatographic applications and for immobilization of biologically-active components, where efficient, intimate contact of the hydrogel with a liquid medium is important.
Inventors
- 👤 Richard B. Provonchee
- 👤 Francis H. Kirkpatrick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 09:04
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/28; B01J20/28014; B01J20/28026; B01D; B01D15/00; B01D15/08; B01J20/28028; B01J20/28033; B01J20/28042; B01J20/28045; B01J20/28047; B01J20/28054; B01J20/28069; B01J20/28078; B01J47/00; B01J47/018; C; C08; C08J; C08J9/00; C08J9/36; C08J9/40; C08J9/42; B01D15/26; B01D15/34; C08J2205/00; C08J2205/02; C08J2403/00; Y; Y10; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249955; Y10T428/249958; Y10T428/249994; Y10T428/29; Y10T428/2913; Y10T428/2933; Y10T428/2964; Y10T428/2967; Y10T428/2982; Y10T442/00; Y10T442/20; Y10T442/2033
Claims Analysis
Total Claims: 51
Claim 1
Independent Claim
48 words
A gel-in-matrix combination comprising a three-dimensional porous support matrix and a porous fractured hydrogel fixedly disposed therein, in which said fractured hydrogel has: (a) a void volume of about 10-90%; and (b) a plurality of porous fractures comprising channels having a mean characteristic dimension of about 0.1-1,000 μm.
Claim 2
Dependent Claim
48 words
A gel-in-matrix combination comprising a three-dimensional porous support matrix and a porous fractured hydrogel fixedly disposed therein, in which said fractured hydrogel has: (a) a void volume of about 10-90%; and (b) a plurality of porous fractures comprising channels having a mean characteristic dimension of about 0.1-1,000 μm.
Claim 3
Dependent Claim
14 words
The gel-in-matrix of claim 1 wherein said fractured hydrogel void volume is about 50-90%.
Claim 4
Dependent Claim
19 words
The gel-in-matrix of claim 1 wherein said hydrogel fracture channels have a mean characteristic dimension of about 1-100 μm.
Claim 5
Dependent Claim
19 words
The gel-in-matrix of claim 2 wherein said hydrogel fracture channels have a mean characteristic dimension of about 1-100 μm.
Claim 6
Dependent Claim
14 words
The gel-in-matrix of claim 1 wherein said hydrogel is thermally reversible to a liquid.
Claim 7
Dependent Claim
18 words
The gel-in-matrix of claim 1 wherein said hydrogel is a polysaccharide which is thermally reversable to a liquid.
Claim 8
Dependent Claim
29 words
The gel-in-matrix of claim 1 wherein said hydrogel is an alginate, carrageenan, agar, agarose, curdlan, pullulan, gellan, a derivatized composition of any of the foregoing, or a mixture thereof.
Claim 9
Dependent Claim
26 words
The gel-in-matrix of claim 3 wherein said hydrogel is an alginate, carrageenan, agar, agarose, a derivatized composition of any of the foregoing, or a mixture thereof.
Claim 10
Dependent Claim
26 words
The gel-in-matrix of claim 4 wherein said hydrogel is an alginate, carrageenan, agar, agarose, a derivatized composition of any of the foregoing, or a mixture thereof.
Claim 11
Dependent Claim
14 words
The gel-in-matrix of claim 1 wherein said hydrogel is an agarose or derivatized agarose.
Claim 12
Dependent Claim
15 words
The gel-in-matrix of claim 4 wherein said hydrogel is an agarose or a derivatized agarose.
Claim 13
Dependent Claim
19 words
The gel-in-matrix of claim 1 wherein said hdyrogel comprises about 0.05-10% w/w gel-forming component based upon the total gel.
Claim 14
Dependent Claim
19 words
The gel-in-matrix of claim 11 wherein said hdyrogel comprises about 0.05-10% w/w gel-forming component based upon the total gel.
Claim 15
Dependent Claim
30 words
The gel-in-matrix of claim 1 wherein said matrix comprises a material inert with respect to the hydrogel, having pores with a mean characteristic dimension of less than about 2 mm.
Claim 16
Dependent Claim
30 words
The gel-in-matrix of claim 13 wherein the matrix comprises a material inert with respect to the hydrogel, having pores with a mean characteristic dimension of less than about 2 mm.
Claim 17
Dependent Claim
10 words
The gel-in-matrix of claim 1 wherein said matrix is hydrophilic.
Claim 18
Dependent Claim
10 words
The gel-in-matrix of claim 15 wherein said matrix is hydrophilic.
Claim 19
Dependent Claim
25 words
The gel-in-matrix of claim 1 wherein aid matrix is a porous: plastic, ceramic, metal, flexible plastic foam, rigid plastic foam, or mass of nonwoven fibers.
Claim 20
Dependent Claim
25 words
The gel-in-matrix of claim 17 wherein said matrix is a porous: plastic, ceramic, metal, flexible plastic foam, rigid plastic foam, or mass of nonwoven fibers.
Claim 21
Dependent Claim
15 words
The gel-in-matrix of claim 1 wherein said matrix is a reticulated open-cell porous plastic foam.
Claim 22
Dependent Claim
15 words
The gel-in-matrix of claim 19 wherein said matrix is a reticulated open-cell porous plastic foam.
Claim 23
Dependent Claim
12 words
The gel-in-matrix of claim 1 wherein said matrix is a polyurethane foam.
Claim 24
Dependent Claim
12 words
The gel-in-matrix of claim 21 wherein said matrix is a polyurethane foam.
Claim 25
Dependent Claim
15 words
The gel-in-matrix of claim 1 wherein said matrix contains about 20-200 pores per square inch.
Claim 26
Dependent Claim
15 words
The gel-in-matrix of claim 23 wherein said matrix contains about 20-200 pores per square inch.
Claim 27
Dependent Claim
14 words
The gel-in-matrix of claim 1 wherein said matrix is a mass of nonwoven fibers.
Claim 28
Dependent Claim
14 words
The gel-in-matrix of claim 19 wherein said matrix is a mass of nonwoven fibers.
Claim 29
Dependent Claim
28 words
The gel-in-matrix of claim 1 wherein said composition is in the form of a thin sheet, a strand, a cylindrical plug, a cylindrical annulus, a disc, or beads.
Claim 30
Dependent Claim
28 words
The gel-in-matrix of claim 19 wherein said composition is in the form of a thin sheet, a strand, a cylindrical plug, a cylindrical annulus, a disc, or beads.
Claim 31
Dependent Claim
28 words
The gel-in-matrix of claim 25 wherein said composition is in the form of a thin sheet, a strand, a cylindrical plug, a cylindrical annulus, a disc, or beads.
Claim 32
Dependent Claim
28 words
The gel-in-matrix of claim 27 wherein said composition is in the form of a thin sheet, a strand, a cylindrical plug, a cylindrical annulus, a disc, or beads.
Claim 33
Dependent Claim
41 words
The gel-in-matrix of claim 1 wherein said hydrogel further comprises at least one buffer, conventional hydrogel additive, or organic solvent in an amount or of a type which is miscible with an aqueous medium from which said hydrogel has been formed.
Claim 34
Dependent Claim
18 words
The gel-in-matrix of claim 1 wherein said hydrogen further comprises a solid or immiscible liquid immobilized within it.
Claim 35
Dependent Claim
18 words
The gel-in-matrix of claim 19 wherein said hydrogel further comprises a solid or immiscible liquid immobilized within it.
Claim 36
Dependent Claim
18 words
The gel-in-matrix of claim 21 wherein said hydrogel further comprises a solid or immiscible liquid immobilized within it.
Claim 37
Dependent Claim
18 words
The gel-in-matrix of claim 23 wherein said hdyrogel further comprises a solid or immiscible liquid immobilized within it.
Claim 38
Dependent Claim
18 words
The gel-in-matrix of claim 27 wherein said hydrogel further comprises a solid or immiscible liquid immobilized within it.
Claim 39
Dependent Claim
18 words
The gel-in-matrix of claim 1 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 40
Dependent Claim
18 words
The gel-in-matrix of claim 4 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 41
Dependent Claim
18 words
The gel-in-matrix of claim 9 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 42
Dependent Claim
18 words
The gel-in-matrix of claim 13 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 43
Dependent Claim
18 words
The gel-in-matrix of claim 19 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 44
Dependent Claim
18 words
The gel-in-matrix of claim 25 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 45
Dependent Claim
18 words
The gel-in-matrix of claim 30 wherein said hydrogel contains at least one biologically active component immobilized within it.
Claim 46
Dependent Claim
26 words
A method for manufacturing the gel-in-matrix of claim 1 comprising creating the fractures in said gel by partially dewatering said hydrogel in situ within said matrix.
Claim 47
Dependent Claim
23 words
The method of claim 45 wherein said hydrogen is dewatered until it contains about 10-90% of its original weight prior to said dewatering.
Claim 48
Dependent Claim
23 words
The method of claim 45 wherein said hydrogel is dewatered until it contains about 15-50% of its original weight prior to said dewatering
Claim 49
Dependent Claim
9 words
A gel-in-matrix produced by the method of claim 45.
Claim 50
Dependent Claim
9 words
The gel-in-matrix produced by the method of claim 46.
Claim 51
Dependent Claim
9 words
A gel-in-matrix produced by the method of claim 47.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-10 | 1997-07-12 | 1998-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-10 | 2001-07-12 | 2002-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-10 | 2005-07-12 | 2006-01-11 | $7700.00 | Window Closed / Lapsed |