US4649075A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Transdermal and transmucosal vortexed foam devices and the method of making
Assignee: Individual
•
Filing: 1984-08-09
•
Granted: 1987-03-10
•
Expires: 2004-08-09
Abstract
Abstract A device for delivery of medicaments to epidermal and mucosal surfaces, comprising a microporous outer portion made from polymeric foam, and a macroporous inner portion made from polymeric foam disposed within the outer portion and in substantial communication with the outer portion which is adapted for incorporating a medicament therein, wherein the macroporous inner portion has at least one free surface not in communication with the microporous outer portion, and the pore size ratio of the macroporous inner portion to the microporous outer portion is between about 2 to 1 and 1.67 to 1.
Inventors
- 👤 Leonora Jost
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 03:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; Y; Y10; Y10S; Y10S428/00; Y10S428/905; Y10T; Y10T428/00; Y10T428/249921; Y10T428/249953; Y10T428/249954; Y10T428/249981
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
94 words
A device for delivery of medicaments to epidermal and mucosal surfaces comprising: (a) a microporous outer portion made from polymeric foam, and (b) A macroporous inner portion made from polymeric foam disposed within the outer portion and in substantial communication therewith which is adapted for the incorporation therein of a medicament, wherein the macroporous inner portion has at least one free surface not in communication with the microporous outer portion, the pore size ratio of the macroporous inner portion to the microporous outer portion is between about 2 to 1 and 1.67 to 1.
Claim 2
Independent Claim
94 words
A device for delivery of medicaments to epidermal and mucosal surfaces comprising: (a) a microporous outer portion made from polymeric foam, and (b) A macroporous inner portion made from polymeric foam disposed within the outer portion and in substantial communication therewith which is adapted for the incorporation therein of a medicament, wherein the macroporous inner portion has at least one free surface not in communication with the microporous outer portion, the pore size ratio of the macroporous inner portion to the microporous outer portion is between about 2 to 1 and 1.67 to 1.
Claim 3
Dependent Claim
13 words
A device as recited in claim 1, wherein the device is disc shaped.
Claim 4
Dependent Claim
14 words
A device as recited in claim 1, wherein said device is frusto-conical in shape.
Claim 5
Dependent Claim
14 words
A device as recited in claim 1, wherein said device is cylindrical in shape.
Claim 6
Dependent Claim
17 words
A device as recited in claim 1, wherein the polymeric foam is a polyester, polyethylene or polypropylene.
Claim 7
Dependent Claim
29 words
A device as recited in claim 1, wherein said microporous outer portion has 1,000 pores per linear inch and said macroporous inner portion has 200 pores per linear inch.
Claim 8
Dependent Claim
20 words
A device as recited in claim 1, further comprising an adhesive strip attached to the outer surface of said device.
Claim 9
Independent Claim
100 words
A device for delivery of medicaments to epidermal and mucosal surfaces comprising: (a) a microporous outer portion made from polymeric foam; (b) a macroporous inner portion made from polymeric foam disposed within the outer portion and in substantial communication therewith which is adapted for the incorporation therein of a medicament; and (c) a medicament incorporated in the macroporous inner portion, wherein the macroporous inner portion has at least one free surface not in communication with the microporous outer portion, and the pore size ratio of the macroporous inner portion to the microporous outer portion is between about 18:1 and 1.67:1.
Claim 10
Independent Claim
100 words
A device for delivery of medicaments to epidermal and mucosal surfaces comprising: (a) a microporous outer portion made from polymeric foam; (b) a macroporous inner portion made from polymeric foam disposed within the outer portion and in substantial communication therewith which is adapted for the incorporation therein of a medicament; and (c) a medicament incorporated in the macroporous inner portion, wherein the macroporous inner portion has at least one free surface not in communication with the microporous outer portion, and the pore size ratio of the macroporous inner portion to the microporous outer portion is between about 18:1 and 1.67:1.
Claim 11
Dependent Claim
13 words
A device as recited in claim 8 wherein said device is disc shaped.
Claim 12
Dependent Claim
14 words
A device as recited in claim 8, wherein said device is frusto-conical in shape.
Claim 13
Dependent Claim
14 words
A device as recited in claim 8, wherein said device is cylindrical in shape.
Claim 14
Dependent Claim
27 words
A device as recited in claim 8, wherein the polymeric foam is a polyester foam free of 1,4 dioxane, with a maximum content of 1 PPM TDA.
Claim 15
Dependent Claim
16 words
A device as recited in claim 8, wherein the medicament is supplied as a medicated gel.
Claim 16
Dependent Claim
22 words
A device as recited in claim 13, wherein the medicated gel comprises glycerin, water, gelatin and one or more water soluable medicaments.
Claim 17
Dependent Claim
21 words
A device as recited in claim 13, wherein the medicated gel is coated on the exterior of the macroporous inner portion.
Claim 18
Dependent Claim
14 words
A device as recited in claim 8, wherein the medicament is a chemotherapeutic agent.
Claim 19
Dependent Claim
14 words
A device as recited in claim 8, wherein the medicament is a spermicidal agent.
Claim 20
Dependent Claim
29 words
A device as recited in claim 17 wherein the spermicidal agent is nonoxynol-9 or octoxynol, and it is incorporated within the polyester foam matrix forming the macroporous inner portion.
Claim 21
Dependent Claim
14 words
A device as recited in claim 8, wherein the medicament is an antibacterial agent.
Claim 22
Dependent Claim
14 words
A device as recited in claim 8, wherein the medicament is a thyroid regulator.
Claim 23
Dependent Claim
23 words
A device as recited in claim 8, wherein the medicament is potassium iodide (KI) an antiradiation medicament for use as a radioiodine blocker.
Claim 24
Dependent Claim
13 words
A device as recited in claim 8, wherein the medicament is a hormone.
Claim 25
Dependent Claim
12 words
A device as recited in claim 8, wherein the medicament is insulin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-09 | 1990-09-08 | 1991-03-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-09 | 1994-09-08 | 1995-03-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-09 | 1998-09-08 | 1999-03-10 | $7700.00 | Window Closed / Lapsed |